Results 81 to 90 of about 3,837 (194)

Transport Out of the Antarctic Polar Vortex from a Three-dimensional Transport Model [PDF]

, 2002
[1] A three-dimensional chemical transport model is utilized to study the transport out of the Antarctic polar vortex during the southern hemisphere spring.
Bourke, Boville, Bowman, Bowman, Chen, Chen, David J. Karoly, Eugene C. Cordero, Farman, Godin, Hartley, Hartmann, Hartmann, Haynes, Herman, Juckes, Komhyr, Lee, McIntyre, McIntyre, Norton, Plumb, Polvani, Proffitt, Randel, Rasch, Rasch, Rasch, Rosenfield, Rosenfield, Salby, Schoeberl, Schoeberl, Seaman, Shuhua Li, Solomon, Swinbank, Tuck, Tuck, Tuck, Wauben, Waugh, Williamson   +42 more
core   +4 more sources

Programmed Cell Death Protein 10 (PDCD10) Regulates Vesicle Trafficking and Contributes to the Progression of Clear Cell Renal Cell Carcinoma

Journal of Extracellular Vesicles, Volume 14, Issue 6, June 2025.
ABSTRACT Vesicle trafficking is an essential cellular process that plays an important role in tumour progression. Here, we performed a comprehensive transcriptomic and proteomic analysis on 50 clear cell renal cell carcinoma (ccRCC) tumour samples, and the data systematically depicted the alterations in the molecular landscape.
Rui Wang, Tianyu Lin, Yi Liu, Hao Wang, Xinyu Liu, Yihan Dong, Jiaxin Li, Huamao Jiang, Ruibing Chen, Yong Wang, Dan Yue   +10 more
wiley   +1 more source

Systematic pharmacological screens uncover novel pathways involved in cerebral cavernous malformations

EMBO Molecular Medicine, 2018
Cerebral cavernous malformations (CCMs) are vascular lesions in the central nervous system causing strokes and seizures which currently can only be treated through neurosurgery. The disease arises through changes in the regulatory networks of endothelial
Cécile Otten, Jessica Knox, Gwénola Boulday, Mathias Eymery, Marta Haniszewski, Martin Neuenschwander, Silke Radetzki, Ingo Vogt, Kristina Hähn, Coralie De Luca, Cécile Cardoso, Sabri Hamad, Carla Igual Gil, Peter Roy, Corinne Albiges‐Rizo, Eva Faurobert, Jens P von Kries, Mónica Campillos, Elisabeth Tournier‐Lasserve, W Brent Derry, Salim Abdelilah‐Seyfried   +20 more
doaj   +1 more source

Modeling wet deposition and concentration of inorganics over Northeast Asia with MRI-PM/c [PDF]

, 2012
We conducted a regional-scale simulation over Northeast Asia for the year 2006 using an aerosol chemical transport model, with time-varying lateral and upper boundary concentrations of gaseous species predicted by a global stratospheric and tropospheric ...
H. Ueda, K. Sato, M. Deushi, M. Kajino, N. Oshima, T. Maki, T. Ohizumi, Y. Inomata   +7 more
core   +1 more source

Upregulation of transmembrane endothelial junction proteins in human cerebral cavernous malformations [PDF]

, 2010
OBJECT: Cerebral cavernous malformations (CCMs) are among the most prevalent cerebrovascular malformations, and endothelial cells seem to play a major role in the disease.
Chappell PM, Felbor U, Hilder TL, Revencu N, Robinson JR, Stahl S, Tsukita S, Vestweber D, Zhu Y   +8 more
core   +1 more source

Early Onset Memory Deficit of WMI Rats Compared to Their Nearly Isogenic WLIs Is Reversed by Enriched Environment in Females

Genes, Brain and Behavior, Volume 24, Issue 3, June 2025.
Enriched environment housing reverses memory deficits in middle‐aged WMI females and attenuates deficits in WMI males. Plasma levels of estradiol and hippocampal gene expression followed the same pattern as memory in WMI females following environmental enrichment and may be involved in reversing the effects of aging on cognitive decline.
Michelle T. Ji, Katherine J. Przybyl, Aspen M. Harter, Mariya Nemesh, Sophia T. Jenz, Anna Yamazaki, Chris Kim, Megan K. Mulligan, Hao Chen, Eva E. Redei   +9 more
wiley   +1 more source

Cis and Trans Effects of Human Genomic Variants on Gene Expression [PDF]

, 2014
This work was funded by the Louis-Jeantet Foundation (http://www.jeantet.ch/), the European Research Council (Grant ID: 260927 http://erc.europa.eu/), the Swiss National Foundation (Grant ID: 130342 http://www.snf.ch), NCCR Frontiers In Genetics (http ...
A Boyd, AC Nica, AC Nica, AH Talukder, Alfonso Buil, AR Wood, AS Dimas, BE Stranger, BE Stranger, BU Schraml, C Wallace, Christopher David Brown, David M. Evans, DF Conrad, DJ Gaffney, DL Nicolae, DM Greenawalt, Donald F. Conrad, E Grundberg, E Klopocki, EE Schadt, Emmanouil T. Dermitzakis, George Davey Smith, GR Abecasis, H Huang, HJ Westra, J Ding, J Millstein, J Zhu, JD Storey, JE Powell, JK Pickrell, John P. Kemp, Julien Bryois, K Hildner, Karen M. Ho, LA Hindorff, M Gutierrez-Arcelus, M Scutari, Matthew Hurles, ND Miller, NL Barbosa-Morais, Panos Deloukas, RW Jones, SB Montgomery, SB Montgomery, SJ Loughran, Stephen B. Montgomery, Susan Ring, T Lappalainen, TR Insel, W Wang, Y Li, Y Li   +53 more
core   +5 more sources

Correlates of Continued Church Membership Intention: An Empirical Study of Religion in Ghana

Journal for the Scientific Study of Religion, Volume 64, Issue 2, Page 123-147, June 2025.
Abstract This study examines the factors influencing continued church membership intention in Ghana, focusing on the key correlates of this behavior. Using structural equation modeling (SEM) the survey data collected were analyzed. The findings highlight charismatic leadership, religious experience, corporate social responsibility, personal needs ...
Andrews Agya Yalley
wiley   +1 more source

Familial cerebral cavernous malformation presenting with epilepsy caused by mutation in the CCM2 gene

Medicine, 2020
Abstract Rationale: Cerebral cavernous malformation (CCM) of the familial type is caused by abnormalities in the CCM1, CCM2, and CCM3 genes. These 3 proteins forming a complex associate with the maintenance of vascular endothelial cell-cell junctions.
Kazuhiro Ishii, Naoki Tozaka, Satoshi Tsutsumi, Ai Muroi, Akira Tamaoka   +4 more
openaire   +2 more sources

Targeted Therapies for Slow‐Flow Vascular Malformations

Australasian Journal of Dermatology, Volume 66, Issue 3, Page 142-151, May 2025.
ABSTRACT Advances in genetic sequencing technologies have enabled the identification of key activating somatic variants in cellular signalling pathways involved in the pathogenesis of vascular malformations. Given that these genetic variants are also implicated in the pathogenesis of several cancers, the repurposing of targeted therapies developed in ...
Grace X. Li, Deshan F. Sebaratnam, James P. Pham   +2 more
wiley   +1 more source