Results 71 to 80 of about 1,951 (186)

Systematic pharmacological screens uncover novel pathways involved in cerebral cavernous malformations

EMBO Molecular Medicine, 2018
Cerebral cavernous malformations (CCMs) are vascular lesions in the central nervous system causing strokes and seizures which currently can only be treated through neurosurgery. The disease arises through changes in the regulatory networks of endothelial
Cécile Otten, Jessica Knox, Gwénola Boulday, Mathias Eymery, Marta Haniszewski, Martin Neuenschwander, Silke Radetzki, Ingo Vogt, Kristina Hähn, Coralie De Luca, Cécile Cardoso, Sabri Hamad, Carla Igual Gil, Peter Roy, Corinne Albiges‐Rizo, Eva Faurobert, Jens P von Kries, Mónica Campillos, Elisabeth Tournier‐Lasserve, W Brent Derry, Salim Abdelilah‐Seyfried   +20 more
doaj   +1 more source

Programmed Cell Death Protein 10 (PDCD10) Regulates Vesicle Trafficking and Contributes to the Progression of Clear Cell Renal Cell Carcinoma

Journal of Extracellular Vesicles, Volume 14, Issue 6, June 2025.
ABSTRACT Vesicle trafficking is an essential cellular process that plays an important role in tumour progression. Here, we performed a comprehensive transcriptomic and proteomic analysis on 50 clear cell renal cell carcinoma (ccRCC) tumour samples, and the data systematically depicted the alterations in the molecular landscape.
Rui Wang, Tianyu Lin, Yi Liu, Hao Wang, Xinyu Liu, Yihan Dong, Jiaxin Li, Huamao Jiang, Ruibing Chen, Yong Wang, Dan Yue   +10 more
wiley   +1 more source

Early Onset Memory Deficit of WMI Rats Compared to Their Nearly Isogenic WLIs Is Reversed by Enriched Environment in Females

Genes, Brain and Behavior, Volume 24, Issue 3, June 2025.
Enriched environment housing reverses memory deficits in middle‐aged WMI females and attenuates deficits in WMI males. Plasma levels of estradiol and hippocampal gene expression followed the same pattern as memory in WMI females following environmental enrichment and may be involved in reversing the effects of aging on cognitive decline.
Michelle T. Ji, Katherine J. Przybyl, Aspen M. Harter, Mariya Nemesh, Sophia T. Jenz, Anna Yamazaki, Chris Kim, Megan K. Mulligan, Hao Chen, Eva E. Redei   +9 more
wiley   +1 more source

Familial cerebral cavernous malformation presenting with epilepsy caused by mutation in the CCM2 gene

Medicine, 2020
Abstract Rationale: Cerebral cavernous malformation (CCM) of the familial type is caused by abnormalities in the CCM1, CCM2, and CCM3 genes. These 3 proteins forming a complex associate with the maintenance of vascular endothelial cell-cell junctions.
Kazuhiro Ishii, Naoki Tozaka, Satoshi Tsutsumi, Ai Muroi, Akira Tamaoka   +4 more
openaire   +2 more sources

Mann-Whitney U-Test Scores and for the probability values of equality of medians (p), for comparisons of CCM2 scores of birds and sauropods, and the CCM2 scores of birds from different environments.

, 2012
Mann-Whitney U-Test Scores and for the probability values of equality of medians (p), for comparisons of CCM2 scores of birds and sauropods, and the CCM2 scores of birds from different environments.
Neil Brocklehurst (156277), Jingmai O'Connor (156296), Philip D. Mannion (156289), Paul Upchurch (156283)   +3 more
core   +1 more source

Correlates of Continued Church Membership Intention: An Empirical Study of Religion in Ghana

Journal for the Scientific Study of Religion, Volume 64, Issue 2, Page 123-147, June 2025.
Abstract This study examines the factors influencing continued church membership intention in Ghana, focusing on the key correlates of this behavior. Using structural equation modeling (SEM) the survey data collected were analyzed. The findings highlight charismatic leadership, religious experience, corporate social responsibility, personal needs ...
Andrews Agya Yalley
wiley   +1 more source

The mean CCM2 scores for birds assigned to the major Mesozoic avian clades.

, 2012
The mean CCM2 scores for birds assigned to the major Mesozoic avian clades.
Neil Brocklehurst (156277), Jingmai O'Connor (156296), Philip D. Mannion (156289), Paul Upchurch (156283)   +3 more
core   +1 more source

Targeted Therapies for Slow‐Flow Vascular Malformations

Australasian Journal of Dermatology, Volume 66, Issue 3, Page 142-151, May 2025.
ABSTRACT Advances in genetic sequencing technologies have enabled the identification of key activating somatic variants in cellular signalling pathways involved in the pathogenesis of vascular malformations. Given that these genetic variants are also implicated in the pathogenesis of several cancers, the repurposing of targeted therapies developed in ...
Grace X. Li, Deshan F. Sebaratnam, James P. Pham   +2 more
wiley   +1 more source

CCM1 and CCM2 variants in patients with cerebral cavernous malformation in an ethnically Chinese population in Taiwan [PDF]

Scientific Reports, 2019
AbstractCerebral cavernous malformation (CCM) is a vascular malformation characterized by clustered enlarged capillary-like channels in the central nervous system. The genes harboring variants in patients with CCM includeCCM1/Krev interaction trapped-1,CCM2/MGC4607, andCCM3/programmed cell death protein 10.
Chun-Wei Chang, Peng-Wei Hsu, Kuo-Chen Wei, Chia-Wen Chang, Hon-Chung Fung, Mo-Song Hsih, Wen-Chuin Hsu, Long-Sun Ro, Chen-Nen Chang, Jiun-Jie Wang, Yih-Ru Wu, Sien-Tsong Chen   +11 more
openaire   +2 more sources

Association Analysis of the Circulating Proteome With Sarcopenia‐Related Traits Reveals Potential Drug Targets for Sarcopenia

Journal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 1, February 2025.
ABSTRACT Background Sarcopenia severely affects the physical health of the elderly. Currently, there is no specific drug available for sarcopenia. This study aims to identify pathogenic proteins and druggable targets for sarcopenia through Mendelian randomization (MR)–based analytical framework.
Simin Wen, Siqi Xu, Xizeng Zong, Shifeng Wen, Wende Xiao, Weipeng Zheng, Han Cen, Zhaohua Zhu, Jingyu Xie, Yan Zhang, Changhai Ding, Guangfeng Ruan   +11 more
wiley   +1 more source