Results 91 to 100 of about 3,837 (194)

Association Analysis of the Circulating Proteome With Sarcopenia‐Related Traits Reveals Potential Drug Targets for Sarcopenia

Journal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 1, February 2025.
ABSTRACT Background Sarcopenia severely affects the physical health of the elderly. Currently, there is no specific drug available for sarcopenia. This study aims to identify pathogenic proteins and druggable targets for sarcopenia through Mendelian randomization (MR)–based analytical framework.
Simin Wen, Siqi Xu, Xizeng Zong, Shifeng Wen, Wende Xiao, Weipeng Zheng, Han Cen, Zhaohua Zhu, Jingyu Xie, Yan Zhang, Changhai Ding, Guangfeng Ruan   +11 more
wiley   +1 more source

ccm2-like is required for cardiovascular development as a novel component of the Heg-CCM pathway

Developmental Biology, 2013
The Heart of Glass-Cerebral Cavernous Malformation (Heg-CCM) pathway is essential for normal cardiovascular development in zebrafish and mouse. In zebrafish, the Heg-CCM pathway mutants santa(ccm1/san), valentine (ccm2/vtn), and heart of glass (heg) exhibit severely dilated hearts and inflow tracts and a complete absence of blood circulation.
Rosen, Jonathan N., Sogah, Vanessa M., Ye, Lillian Y., Mably, John D.   +3 more
openaire   +2 more sources

CCM1 and CCM2 variants in patients with cerebral cavernous malformation in an ethnically Chinese population in Taiwan [PDF]

Scientific Reports, 2019
AbstractCerebral cavernous malformation (CCM) is a vascular malformation characterized by clustered enlarged capillary-like channels in the central nervous system. The genes harboring variants in patients with CCM includeCCM1/Krev interaction trapped-1,CCM2/MGC4607, andCCM3/programmed cell death protein 10.
Chun-Wei Chang, Peng-Wei Hsu, Kuo-Chen Wei, Chia-Wen Chang, Hon-Chung Fung, Mo-Song Hsih, Wen-Chuin Hsu, Long-Sun Ro, Chen-Nen Chang, Jiun-Jie Wang, Yih-Ru Wu, Sien-Tsong Chen   +11 more
openaire   +2 more sources

Mosaic RAS/MAPK variants cause sporadic vascular malformations which respond to targeted therapy. [PDF]

, 2018
BACKGROUND: Sporadic vascular malformations (VMs) are complex congenital anomalies of blood vessels that lead to stroke, life-threatening bleeds, disfigurement, overgrowth, and/or pain.
Al-Olabi, L, Andrews, KA, Baird, W, Barnacle, A, Biesecker, LG, Bulstrode, N, Clark, G, Dowsett, K, Glover, M, Gordon, K, Hargrave, D, Huson, SM, Jacques, TS, James, G, Joseph, AP, Kangesu, L, Keppler-Noreuil, KM, Khan, A, Kinsler, VA, Knox, R, Kondolf, H, Lindhurst, MJ, Lipson, M, Mahon, C, Mansour, S, Mosica, A, Moss, C, Murthy, A, O'Hara, J, Ong, J, Parker, VE, Patton, EE, Pittman, A, Polubothu, S, Rivière, J-B, Sapp, JC, Sebire, NJ, Semple, RK, Shah, R, Sivakumar, B, Stadnik, P, Thomas, A, Topf, M, Virasami, A, Waelchli, R, Zeng, Z   +45 more
core   +4 more sources

Quality Assessment of Hydrogeomorphological Features Derived from Digital Terrain Models [PDF]

, 2008
Digital terrain models (DTM) provide a model for representing the continuous earth elevation surface that can contain errors introduced by the main phases of generation and modelling. Uncertainty of the model is rarely considered by users.
POGGIO Laura, SOILLE Pierre
core  

The atmospheric ‘cold blob’ over Fennoscandia from October 2023 to January 2024

Weather, Volume 80, Issue 1, Page 10-16, January 2025.
Between October 2023 and January 2024, a persistent region of cold air prevailed over Fennoscandia. While these 4 months were the warmest on record globally, they were all colder than normal in Fennoscandia, in stark contrast to the surrounding mid‐ and high latitudes of the Northern Hemisphere.
Mika Rantanen, Otto Hyvärinen, Andrea Vajda, Alexey Karpechko   +3 more
wiley   +1 more source

Using Bayesian Model Averaging (BMA) to calibrate probabilistic surface temperature forecasts over Iran [PDF]

, 2011
Using Bayesian Model Averaging (BMA), an attempt was made to obtain calibrated probabilistic numerical forecasts of 2-m temperature over Iran. The ensemble employs three limited area models (WRF, MM5 and HRM), with WRF used with five different ...
G. A. Vakili, I. Soltanzadeh, M. Azadi
core   +1 more source

Nutrient Discharge from Rivers to Seas for Year 2000 [PDF]

, 2009
The understanding of the fate and impact of pollutants on the functioning of the terrestrial/aquatic interface is a scientific challenge that requires a combination of several disciplines, tools and datasets. In order to support the implementation of the
ALOE Alberto, BOURAOUI Faycal, GRIZZETTI Bruna   +2 more
core   +1 more source

Defective autophagy is a key feature of cerebral cavernous malformations

EMBO Molecular Medicine, 2015
Cerebral cavernous malformation (CCM) is a major cerebrovascular disease affecting approximately 0.3–0.5% of the population and is characterized by enlarged and leaky capillaries that predispose to seizures, focal neurological deficits, and fatal ...
Saverio Marchi, Mariangela Corricelli, Eliana Trapani, Luca Bravi, Alessandra Pittaro, Simona Delle Monache, Letizia Ferroni, Simone Patergnani, Sonia Missiroli, Luca Goitre, Lorenza Trabalzini, Alessandro Rimessi, Carlotta Giorgi, Barbara Zavan, Paola Cassoni, Elisabetta Dejana, Saverio Francesco Retta, Paolo Pinton   +17 more
doaj   +1 more source

Microarray Analysis Reveals Increased Transcriptional Repression and Reduced Metabolic Activity but Not Major Changes in the Core Apoptotic Machinery during Maturation of Sympathetic Neurons [PDF]

, 2016
Postnatal maturation of the neurons whose main phenotype and basic synaptic contacts are already established includes neuronal growth, refinement of synaptic contacts, final steps of differentiation, programmed cell death period (PCD) etc.
Jaan ePalgi, Maria eLehtivaara, Mikk eRaba, Urmas eArumäe, Urmas eArumäe   +4 more
core   +1 more source