Developmental timing of CCM2 loss influences cerebral cavernous malformations in mice [PDF]
Journal of Experimental Medicine, 2011 Cerebral cavernous malformations (CCM) are vascular malformations of the central nervous system (CNS) that lead to cerebral hemorrhages. Familial CCM occurs as an autosomal dominant condition caused by loss-of-function mutations in one of the three CCM genes.
G. Boulday +9 more
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Targeting miR-27a/VE-cadherin interactions rescues cerebral cavernous malformations in mice.
PLoS Biology, 2020 Cerebral cavernous malformations (CCMs) are vascular lesions predominantly developing in the central nervous system (CNS), with no effective treatments other than surgery.
Jia Li +12 more
doaj +1 more source
Linkage to the CCM2 Locus and Genetic Heterogeneity in Familial Cerebral Cavernous Malformation [PDF]
Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, 2003 ABSTRACT:Background:Cerebral cavernous malformation (CCM) is a form of intracranial vascular disease that may arise sporadically or be dominantly inherited. Linkage studies have revealed genetic heterogeneity among the dominantly inherited forms suggesting the existence of at least three loci called CCM1, CCM2 and CCM3.Methods:In the present study, we ...
Dupré, Nicolas +10 more
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Frontiers in Molecular Biosciences, 2021 Cerebral cavernous malformations are slow-flow thrombi-containing vessels induced by two-step inactivation of the CCM1, CCM2 or CCM3 gene within endothelial cells. They predispose to intracerebral bleedings and focal neurological deficits.
Christiane D. Much +9 more
doaj +1 more source
PDCD10 gene mutations in multiple cerebral cavernous malformations. [PDF]
PLoS ONE, 2014 Cerebral cavernous malformations (CCMs) are vascular abnormalities that may cause seizures, intracerebral haemorrhages, and focal neurological deficits.
Maria Sole Cigoli +22 more
doaj +1 more source
Influence of assimilating rainfall derived from WSR-88D radar on the rainstorm forecasts over the southwestern United States [PDF]
, 2006 In this study, the impact of rainfall assimilation on the forecasts of convective rainfall over the mountainous areas in the southwestern United States is investigated. The rainfall is derived from the U.S.
Gao, X, Sorooshian, S, Xiao, Q, Xu, J
core +3 more sources
Study of tundish slag entrainment using physical modelling [PDF]
, 2016 This paper deals with the possibilities of using physical modelling to study the slag entrainment in the tundish. A level of steel in the tundish is changing during sequential continuous casting.
Gryc, Karel +7 more
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Small GTPase Rap1 Is Essential for Mouse Development and Formation of Functional Vasculature [PDF]
, 2015 BACKGROUND: Small GTPase Rap1 has been implicated in a number of basic cellular functions, including cell-cell and cell-matrix adhesion, proliferation and regulation of polarity.
Chrzanowska-Wodnicka, Magdalena +3 more
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CCM2 and CCM3 proteins contribute to vasculogenesis and angiogenesis in human placenta.
Histology and histopathology, 2009 Placenta as an ideal model to study angiogenic mechanisms have been established in previous studies. There are two processes, vasculogenesis and angiogenesis, involved in blood vessel formation during placental development. Therefore, blood vessel formation is a crucial issue that might cause vascular malformations. One of the vascular malformations is
Tanriover, Gamze +4 more
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Micro-CT Imaging Reveals Mekk3 Heterozygosity Prevents Cerebral Cavernous Malformations in Ccm2-Deficient Mice. [PDF]
PLoS ONE, 2016 Mutations in CCM1 (aka KRIT1), CCM2, or CCM3 (aka PDCD10) gene cause cerebral cavernous malformation in humans. Mouse models of CCM disease have been established by deleting Ccm genes in postnatal animals.
Jaesung P Choi +7 more
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