Exceptional aggressiveness of cerebral cavernous malformation disease associated with PDCD10 mutations. [PDF]
, 2015 PurposeThe phenotypic manifestations of cerebral cavernous malformation disease caused by rare PDCD10 mutations have not been systematically examined, and a mechanistic link to Rho kinase-mediated hyperpermeability, a potential therapeutic target, has ...
Akers, Amy L +16 more
core +2 more sources
Developmental timing of CCM2 loss influences cerebral cavernous malformations in mice [PDF]
Journal of Experimental Medicine, 2011 Cerebral cavernous malformations (CCM) are vascular malformations of the central nervous system (CNS) that lead to cerebral hemorrhages. Familial CCM occurs as an autosomal dominant condition caused by loss-of-function mutations in one of the three CCM genes.
G. Boulday +9 more
openaire +2 more sources
Simplex cerebral cavernous malformations with MAP3K3 mutation have distinct clinical characteristics
Frontiers in Neurology, 2022 ObjectivesTo investigate the clinical characteristics of cerebral cavernous malformations (CCMs) with MAP3K3 somatic mutation.MethodsWe performed a retrospective review of our CCMs database between May 2017 and December 2019.
Ran Huo +25 more
doaj +1 more source
A Case Report and Overview of Familial Cerebral Cavernous Malformation Pathogenesis in an Adult Patient [PDF]
, 2018 OBJECTIVE We present a case of a 39 year-old woman who presented with a solitary cavernous malformation hemorrhage without any other lesions, and subsequently presented several months later with a new hemorrhage from a de novo lesion.
Arul, BS, Manu K. +2 more
core +2 more sources
Physical modelling of tundish slag entrainment under various technological conditions [PDF]
, 2017 This paper deals with the issue of physical modelling of vortexes creation and tundish slag entrainment over the mouth of the nozzle into the individual casting strands. Proper physical model is equivalent to the operational continuous casting machine No.
Gryc, Karel +7 more
core +1 more source
Intracerebral Hemorrhage and Ischemic Stroke of Different Etiologies Have Distinct Alternatively Spliced mRNA Profiles in the Blood: a Pilot RNA-seq Study. [PDF]
, 2015 Whole transcriptome studies have used 3'-biased expression microarrays to study genes regulated in the blood of stroke patients. However, alternatively spliced messenger RNA isoforms have not been investigated for ischemic stroke or intracerebral ...
Ander, Bradley P +8 more
core +2 more sources
Modelo de cuantificación del consumo energético en edificación [PDF]
, 2012 The research conducted in this paper focuses on the generation of a model for the quantification of energy consumption in building. This is to be done through one of the most relevant environmental impact indicators associated with weight per m2 of ...
Mercader-Moyano, Pilar +2 more
core +2 more sources
Water vapor transport in the NCAR CCM2
Tellus A: Dynamic Meteorology and Oceanography, 1994 The NCAR Community Climate Model, Version 2, uses the spectral transform method for the underlying dry dynamical fluid flow component, and a monotonic, semi-Lagrangian transport algorithm for water vapor specific humidity. The reasons for this choice of 2 different approaches for these different components are reviewed, and the details of the ...
Williamson, David L., Rasch, Philip J.
openaire +2 more sources
DIAL measurement of lower tropospheric ozone over Saga (33.24° N, 130.29° E), Japan, and comparison with a chemistry–climate model [PDF]
Atmospheric Measurement Techniques, 2014 We have improved an ozone DIfferential Absorption Lidar (DIAL) system, originally developed in March 2010. The improved DIAL system consists of a Nd:YAG laser and a 2 m Raman cell filled with 8.1 × 105 Pa of CO2 gas which generate four Stokes lines (276,
O. Uchino +18 more
doaj +1 more source
Deletions in CCM2 Are a Common Cause of Cerebral Cavernous Malformations [PDF]
The American Journal of Human Genetics, 2007 Cerebral cavernous malformations (CCMs) are vascular abnormalities of the brain that can result in a variety of neurological disabilities, including hemorrhagic stroke and seizures. Mutations in the gene KRIT1 are responsible for CCM1, mutations in the gene MGC4607 are responsible for CCM2, and mutations in the gene PDCD10 are responsible for CCM3. DNA
Liquori, Christina L. +6 more
openaire +2 more sources