Results 151 to 160 of about 37,429 (252)

The function of chemokine-driven glial-neuronal interaction in chronic pain. [PDF]

Front Neurosci
Fan M, Liang Z, Shen J, Yang H, Zhao L, Li M, Zheng J.   +6 more
europepmc   +1 more source

VSMC phenotypic switching in thoracic aortic aneurysm at single‐cell resolution: Trajectories, regulatory circuits, and spatial niches

Clinical and Translational Discovery, Volume 6, Issue 3, June 2026.
•Single‐cell/spatial multi‐omics identify four VSMC phenotypic states in TAA progression. •KLF4 as master hub (TGF‐β/TNF‐α/mechanical stress) orchestrating chromatin remodelling. •Pseudotime trajectories mapping contractile phenotypes towards osteogenic (RUNX2/SOX9) and inflammatory (TNF‐α/IL‐6) fates within spatial medial niches. •cfDNA biomarkers and
Zehua Shao, Chunguang Guo, Zhongyuan Lu, Jianyang Liu, Hao Tang, Hongwei Guo, Zhidong Zhang   +6 more
wiley   +1 more source

CCR2^- T peripheral helper cells as potential coordinators of local immune architecture in human cancer. [PDF]

Discov Immunol
Crespo Oliva CDC, Gerber Z, Jean D, Allard-Chamard H, Labrie M.   +4 more
europepmc   +1 more source

Development and functional adaptation of intestinal macrophages across the lifespan

Clinical &Translational Immunology, Volume 15, Issue 6, 2026.
This article discusses intestinal macrophage development, including the influence of developmental origins and life stages; ontogeny and functional heterogeneity; preclinical and clinical evidence. Abstract Macrophages of the gastrointestinal system are central regulators of gut development, homeostasis and disease, yet their origin, functional ...
Baha Mustafa, Elisa L Hill‐Yardin, Sarah J Spencer   +2 more
wiley   +1 more source

RNA-binding protein MBNL2 mitigates neuropathic pain after chemotherapy through destabilizing CCR2 expression in primary sensory neurons. [PDF]

Neurotherapeutics
Yan K, Ma R, Wang B, Feng X, Li X, Meng X, Shang H, Kidd BM, Swanson MS, Hu H, Tao YX.   +10 more
europepmc   +1 more source

Effect of CXCR5, PD‐1 and ICOS on B‐cell responses and relevance to myasthenia gravis

Clinical &Translational Immunology, Volume 15, Issue 6, 2026.
This study compared the efficacy of PD‐1 and ICOS molecules in antibody production within CXCR5+ and CXCR5− CD4+ T cells; it demonstrates that PD‐1+ T cells provide the most effective B cell support, a finding also validated in autoantibody production in myasthenia gravis.
Merve Çebi, Arman Çakar, Hacer Durmuş, Yeşim Parman, Güher Saruhan‐Direskeneli   +4 more
wiley   +1 more source

Targeted Thrombolysis via CCR2-Engineered Macrophage-Mimicking Microbubbles Safely Ablates Venous, Arterial, and Microvascular Thrombosis. [PDF]

Adv Sci (Weinh)
Li B, Lu C, Gao S, Chen D, Heng X, Mequanint K, Xing M, Luo G, Li H.   +8 more
europepmc   +1 more source

CCR2 Antagonist CCX872-B [PDF]

, 2020
openaire   +1 more source

Ferroptosis in breast cancer: From adipocyte–immune–iron regulation to therapeutic application

Clinical and Translational Medicine, Volume 16, Issue 6, June 2026.
Ferroptosis in breast cancer is regulated by an integrated adipocyte–immune–iron network rather than by tumour‐intrinsic pathways alone. Adipocyte‐derived lipid substrates and redox metabolites, immune‐cell‐mediated cytokine signalling and iron‐dependent oxidative stress collectively shape a dynamic ferroptosis ecosystem that can shift tumours towards ...
Juan Sun, Yang Qu, Ru Yao, Yidong Zhou
wiley   +1 more source

Time-Course Transcriptomic Analysis Reveals PANoptosis-CCL2 Axis in Herpes Simplex Keratitis. [PDF]

Invest Ophthalmol Vis Sci
Wu C, Ouyang J, Liu Y, Zhao B, Wang Q, Liu J, Jiang J, Hu K.   +7 more
europepmc   +1 more source