Results 141 to 150 of about 37,429 (252)

Myeloid-Derived Suppressor Cells: Function, Migration, and Therapeutic Opportunities in Glioblastoma. [PDF]

Cells
Figg JW, Love C, West I, Jin D, Engelbart M, Ware D, Bessey R, Flores CT.   +7 more
europepmc   +1 more source

CCR2 Antagonist PF-04136309 [PDF]

, 2020
openaire   +1 more source

Liver Kinase B1 in CD11c+ Cells Inhibits Fibrosis in Chronic Pancreatitis via the Oncostatin M Signaling

Advanced Science, Volume 13, Issue 32, 9 June 2026.
This study demonstrates significantly reduced Lkb1 expression in CD11c+ cells in chronic pancreatitis (CP) patients and animal models. Lkb1 deletion enhances CD11c+CD206+ macrophage infiltration and reprograms pancreatic stellate cells (PSCs) via OSM signaling.
Wenqing Zhang, Shan Guo, Yu Zhang, He Ren, Ke Lei, Chenyang Zhao, Qian Yu, Hongqing Luo, Yujing Xiao, Xiaoming Feng, Xiaoyu Li   +10 more
wiley   +1 more source

Activation of α7nAChR prevents maladaptive right ventricular remodeling via inhibiting the recruitment of CCR2⁺ macrophages in experimental pulmonary arterial hypertension. [PDF]

Respir Res
Chen K, Li Z, Lu J, Guo Y, Xie H, Wu F, Wu W.   +6 more
europepmc   +1 more source

Integrating Oncolytic Virus Engineering and Delivery Strategies for Enhanced Cancer Virotherapy

Aggregate, Volume 7, Issue 6, June 2026.
Integrated engineering strategies combining oncolytic virus (OV) design with advanced delivery platforms overcome biological barriers and enhance cancer virotherapy. Genetic engineering improves viral potency and selectivity, while local and systemic delivery systems promote viral protection, tumor targeting, penetration, and tumor microenvironment ...
Jiliang Zhao, Dong Wang, Lei Wang, Hongkai Zhang, Yue Sun, Dan Ding   +5 more
wiley   +1 more source

Antimicrobial therapy combined with C-C chemokine receptor type 2 modulation dampens mycobacteria-aggravated monocyte activation and atherosclerosis. [PDF]

Front Cardiovasc Med
Egoavil-Espejo R, Haller A, Feria MG, Jain SK, Singh M, Zhang B, Qualls JE, Hui DY, Huaman MA.   +8 more
europepmc   +1 more source

Bone Marrow Failure Model Mimics Aplastic Anemia Patients: Single‐Cell Landscape of Immune Response Reveals Novel Mechanisms of Immune Imbalance in AA

Cancer Medicine, Volume 15, Issue 6, June 2026.
Single‐cell RNA‐seq is used in a mouse model of immune‐mediated bone marrow failure. Approach to platelets and mitochondrial data. Analysis of various immune cell landscapes, interactions and driving factors in BMF, involving platelets, CD4+ T Cells, CD8+ T Cells, macrophages, and mitochondrial energy metabolism pathways.
Shuai Tan, Fang Fang, Jing Sun, Yumeng Li, Yaochi Chen, Wanling Sun   +5 more
wiley   +1 more source

Prostatic Escherichia coli infection drives CCR2-dependent recruitment of fibrocytes and collagen production

Disease Models & Mechanisms
Brandon R. Scharpf, Hannah Ruetten, Jaskiran Sandhu, Kyle A. Wegner, Sneha Chandrashekar, Olivia Fox, Anne E. Turco, Clara Cole, Lisa M. Arendt, Douglas W. Strand, Chad M. Vezina   +10 more
doaj   +1 more source

Clinical Significance of Serum CCR2 and IDO1 in Diabetic Peripheral Neuropathy. [PDF]

Diabetes Metab Syndr Obes
Liu Y, Yang Q.
europepmc   +1 more source

Physiology, pathology and therapeutic potential of microglial triggering receptor expressed on myeloid cells 2 signalling: A narrative update

Clinical and Translational Discovery, Volume 6, Issue 3, June 2026.
TREM2hi microglia and macrophages exert distinct roles in neurological diseases. Enhancing TREM2 signalling supports pathological protein or debris clearance and mitigates inflammation in Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, demyelination disorders and stroke, whereas blocking TREM2 may alleviate tauopathy and ...
Zhe Kong, Libin Shen, Daqing Ma, Jinchao Hou   +3 more
wiley   +1 more source