Results 181 to 190 of about 71,715 (302)
The FASEB Journal, Volume 40, Issue 6, 31 March 2026.Schematic overview of the experimental workflow combining single‐cell RNA sequencing and spatial proteomics in a murine model of MASLD. Tissues were isolated, dissociated, and processed for single‐cell transcriptomic profiling to identify distinct cellular clusters and define cell‐type–specific gene expression signatures. Computational analysis enabled
Marica Meroni +18 more
wiley +1 more source
Aerobic Exercise Ameliorates Adverse Vascular Remodeling in Diabetes via PDK1/FoxO1 Axis
The FASEB Journal, Volume 40, Issue 6, 31 March 2026.Reduced PDK1 expression in the carotid arteries of type 1 diabetic mice promotes abnormal FoxO1 expression, thereby inducing inflammatory responses and vascular remodeling. These phenotypes can be ameliorated by regular aerobic exercise. In vitro experiments further confirm that the PDK1‐FoxO1 signaling axis in a high‐glucose environment can induce ...
Xiang Xie +3 more
wiley +1 more source
Imperatorin Mitigates Rosacea‐Like Inflammation by Modulating the Crosstalk Between JNK1 and STAT1
The FASEB Journal, Volume 40, Issue 5, 15 March 2026.IMP treatment disrupts the interaction between JNK1 and STAT1, thereby attenuating STAT1 activity. This interference subsequently diminishes the phosphorylation and nuclear translocation of STAT1, which ultimately results in a reduced production of inflammatory cytokines and chemokines.
Xiaoxue Wang, Zexin Zhu
wiley +1 more source
Molecular Oncology, Volume 20, Issue 3, Page 753-778, March 2026.A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He +8 more
wiley +1 more source
The Journal of Pathology: Clinical Research, Volume 12, Issue 2, March 2026.Abstract Myeloid sarcoma (MS) is a tumorous extramedullary proliferation of blast or blast equivalent cells (e.g., promonocytes or promyelocytes). The most frequent cutaneous presentation is often referred to as leukemia cutis (LC). These lesions, especially without the clinical context of a known bone marrow disease, pose a differential diagnostic ...
Alex Jenei +10 more
wiley +1 more source
PARPi Combining Nanoparticle LIN28B siRNA for the Management of Malignant Ascites
Advanced Science, Volume 13, Issue 16, 18 March 2026.This study demonstrates that co‐inhibition of LIN28B and PARP using siLin28b/DSSP@lip‐PEG‐FA nanoparticles in combination with the PARP inhibitor BMN673 effectively suppresses the accumulation of malignant ascites associated with advanced cancers.
Yan Fang +13 more
wiley +1 more source
CXCR4 identifies transitional bone marrow premonocytes that replenish the mature monocyte pool for peripheral responses [PDF]
, 2016 et al,, Randolph, Gwendalyn J
core +2 more sources