Results 211 to 220 of about 65,957 (231)

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2021
Aims. The rate of progression of HIV-1 disease exhibits a remarkable variation among different individuals. Several natural polymorphisms in the genes for the human CC-chemokine receptors CCR5 and CCR2 are associated with HIV-1 disease. associated with a delayed progression to disease.
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Small molecule CCR2 antagonists

2007
Monocyte chemoattractant protein-1 (MCP-1), also known as CCL2, is a member of the CC family of chemokines. During inflammatory conditions, the production of MCP-1 is upregulated in both immune and non-immune cell types including macrophages, mast cells, fibroblasts, endothelial and epithelial cells, smooth muscle cells, and astrocytes.
Paul J. Higgins, C. Eric Schwartz, Jean-Marie Nicolas   +2 more
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Substituted dipiperidine alcohols as potent CCR2 antagonists

Bioorganic & Medicinal Chemistry Letters, 2008
The synthesis and biological evaluation of a series of substituted dipiperidine alcohols are described. Structure-activity relationship studies led to the discovery of potent CCR2 antagonists displaying IC(50) values in the nanomolar or subnanomolar range. The cinnamoyl compounds had higher binding affinities than the corresponding urea analogs.
Mingde, Xia, Cuifen, Hou, Duane, Demong, Scott, Pollack, Meng, Pan, James, Brackley, Monica, Singer, Michele, Matheis, Druie, Cavender, Michael, Wachter   +9 more
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CCL2/CCR2 signaling pathway in glioblastoma multiforme

Neurochemistry International, 2017
Glioblastoma multiform (GBM) is described as one of the most frequent primary brain tumors. These types of malignancies constitute only 15% of all primary brain tumors. Despite, extensive developments on effective therapeutic methods during the 20th century as well as the first decade of the present century (21st), the median survival rate for patients
Alireza, Vakilian, Hossein, Khorramdelazad, Parisa, Heidari, Zahra, Sheikh Rezaei, Gholamhossein, Hassanshahi   +4 more
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The discovery of novel cyclohexylamide CCR2 antagonists

Bioorganic & Medicinal Chemistry Letters, 2011
As a result of further SAR studies on a piperidinyl piperidine scaffold, we report the discovery of compound 44, a potent, orally bioavailable CCR2 antagonist. While having some in vitro hERG activity, this molecule was clean in an in vivo model of QT prolongation. In addition, it showed excellent efficacy when dosed orally in a transgenic murine model
James C, Lanter, Thomas P, Markotan, Xuqing, Zhang, Nalin, Subasinghe, Fu-An, Kang, Cuifen, Hou, Monica, Singer, Evan, Opas, Sandra, McKenney, Carl, Crysler, Dana, Johnson, Christopher J, Molloy, Zhihua, Sui   +12 more
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Regulation of CCR2 chemokine receptor mRNA stability

Journal of Leukocyte Biology, 1997
Abstract During inflammatory and immunological responses, leukocytes respond to external stimuli by altering the stability of cytokine and cytokine receptor messages. Change in message stability is an effective mechanism for rapidly regulating steady state levels of mRNA.
L, Xu, R, Rahimpour, L, Ran, C, Kong, A, Biragyn, J, Andrews, M, Devries, J M, Wang, D J, Kelvin   +8 more
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CCR2 allele polymorphisms in 15 Chinese ethnic populations

International Journal of Immunogenetics, 2006
SummaryChemokine receptor‐2 (CCR2) is a co‐receptor for the entry of human immunodeficiency virus‐1 (HIV‐1) into the target cells. A mutation in CCR2 (CCR2‐64I) exhibited a protective effect to delay the progression of acquired immunodeficiency syndrome (AIDS).
X L, Zhang, C Y, Zhang, Y, Yu, F, Chen, P, Li, S B, Fu   +5 more
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CCR2: holding B cells back

Blood, 2004
Comment on Flaishon et al, page [933][1] In this issue, Flaishon et al describe a novel role for the chemokine receptor CCR2 and its ligand CCL2/JE in inhibiting the chemotactic response of immature B cells to the chemokine CXCL12/SDF-1. Although best known for their chemoattractant properties,
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CCR2 chemokine receptor and AIDS progression

Nature Medicine, 1997
Recently we reported an association between the CCR2-64I chemokine receptor mutation and delayed onset of AIDS. Michael et al. have now examined the San Francisco Mens Health Study (SFMHS) AIDS cohort for CCR2 genotypes and in this issue of Nature Medicine report that they fail to detect the CCR2-64I association.
Smith, Michael W., Carrington, Mary, Winkler, Cheryl, Lomb, Deborah A., Dean, Michael, Huttley, Gavin A., O'Brien, Stephen J.   +6 more
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Homology modeling of human CCR2 receptor

Medicinal Chemistry Research, 2010
Homology model of CCR2 receptor was built on the basis of the crystal structure of human beta-2 adrenoceptor (PDB ID-2RH1). The model showed 99.3% residues in the core and allowed regions of the Ramachandran plot and there was no residue present in the disallowed regions.
Rajesh Singh, M. Elizabeth Sobhia
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