Results 211 to 220 of about 71,715 (302)

Cardiac resident macrophages: the emerging role in arrhythmogenesis. [PDF]

Front Immunol
Zhao J, Liu J, Zou Y, Li J, Lei M, Tan X, Chen T.   +6 more
europepmc   +1 more source

CCR2/CCR5 Antagonist BMS-813160 [PDF]

, 2020
openaire   +1 more source

Aging‐Derived Alterations in Genomic, Immune, and Metabolic Networks: Implications for Cancer Development and Therapy

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ageing acts as a double‐edged sword in cancer. In the elderly, open chromatin, immunosenescence, and chronic inflammation drive SASP (IL‐6, MMPs), MDSC accumulation and T‐cell suppression, fostering tumor‐promoting microenvironments and limited therapeutic benefit.
Qi Wang, Xue Sun, Xinhao Han, Xingda Zhang, Wenzheng Wang, Hongbin Wang, He Ren, Lina Gu   +7 more
wiley   +1 more source

Prostatic Escherichia coli infection drives CCR2-dependent recruitment of fibrocytes and collagen production

Disease Models & Mechanisms
Brandon R. Scharpf, Hannah Ruetten, Jaskiran Sandhu, Kyle A. Wegner, Sneha Chandrashekar, Olivia Fox, Anne E. Turco, Clara Cole, Lisa M. Arendt, Douglas W. Strand, Chad M. Vezina   +10 more
doaj   +1 more source

Macrophage Infiltration, Activation, and Therapeutic Implication in Skeletal Muscle Injury and Repair. [PDF]

Int J Mol Sci
Wang X, Zhou L.
europepmc   +1 more source

Multifacet Roles of Cellular Senescence in Cancer: Mechanisms and Therapeutic Implications

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Cellular senescence shapes tumor progression through both antitumor and protumor mechanisms. Senescence triggered by telomere shortening restricts malignant transformation and limits tumor cell proliferation, while the senescence‐associated secretory phenotype (SASP) secretion enhances antitumor immunity by activating cytotoxic T cells.
Huajie Mao, Wanning Liu, Yuanyuan Su, Yuxuan Ma, Xiaodi Zhao, Yuanyuan Lu   +5 more
wiley   +1 more source

From inflammatory activation to fibrotic remodeling: the central role of macrophage heterogeneity in frozen shoulder. [PDF]

Front Immunol
Liang H, Liu J.
europepmc   +1 more source

Truncated FOS impairs osteogenic differentiation and induces prostaglandin and NFκB signalling in an in vitro cell‐of‐origin model for osteoid osteoma and osteoblastoma

The Journal of Pathology, Volume 268, Issue 3, Page 263-275, March 2026.
Abstract Osteoid osteoma and osteoblastoma are non‐malignant bone‐forming tumours of the skeleton, characterised by the presence of irregular trabeculae of woven bone. Rearrangements in FOS, and less frequently FOSB, have recently been identified in osteoid osteoma and osteoblastoma.
Suk Wai Lam, Tatiana Belova, Natasja Franceschini, Brendy van den Akker, David GP van IJzendoorn, Harald MM Mikkers, Hailiang Mei, Anne‐Marie Cleton‐Jansen, Marieke L Kuijjer, Karoly Szuhai, Judith VMG Bovée   +10 more
wiley   +1 more source

Targeting tumour-associated macrophages with CCR2 inhibition in combination with FOLFIRINOX in patients with borderline resectable and locally advanced pancreatic cancer: a single-centre, open-label, dose-finding, non-randomised, phase 1b trial.

The Lancet Oncology, 2016
T. Nywening, A. Wang-Gillam, Dominic E. Sanford, B. Belt, R. Panni, Brian M Cusworth, A. Toriola, Rebecca Nieman, Lori A Worley, M. Yano, Kathryn J Fowler, Craig Lockhart, R. Suresh, Benjamin R Tan, K. Lim, Ryan C. Fields, S. Strasberg, William G Hawkins, David G. DeNardo, Peter Goedegebuure, David C. Linehan   +20 more
semanticscholar   +1 more source

Drug Delivery Systems for Resiquimod to Control Myeloid‐Derived Suppressor Cells in Cancer Immunotherapy

WIREs Nanomedicine and Nanobiotechnology, Volume 18, Issue 2, March/April 2026.
Myeloid‐derived suppressor cells (MDSCs) are key contributors to cancer immunotherapy failure and major targets in new therapeutic strategies. We highlight therapeutic approaches to counteract their immunosuppressive functions and discuss recent efforts to optimize drug delivery for controlling MDSCs, focusing on resiquimod as a representative drug ...
Yanying He, Yoon Yeo
wiley   +1 more source