Results 91 to 100 of about 22,866 (205)

Functional expression of CCL8 and its interaction with chemokine receptor CCR3

BMC Immunology, 2017
Background Chemokines and their cognate receptors play important role in the control of leukocyte chemotaxis, HIV entry and other inflammatory diseases.
Baosheng Ge, Jiqiang Li, Zhijin Wei, Tingting Sun, Yanzhuo Song, Naseer Ullah Khan   +5 more
doaj   +1 more source

Leptin Elicits LTC4 Synthesis by Eosinophils Mediated by Sequential Two-Step Autocrine Activation of CCR3 and PGD2 Receptors

Frontiers in Immunology, 2018
Leptin is a cytokine, produced mainly by mature adipocytes, that regulates the central nervous system, mainly to suppress appetite and stimulate energy expenditure.
Natália R. T. Amorim, Tatiana Luna-Gomes, Tatiana Luna-Gomes, Marcos Gama-Almeida, Glaucia Souza-Almeida, Claudio Canetti, Bruno L. Diaz, Peter F. Weller, Patricia Torres Bozza, Clarissa M. Maya-Monteiro, Christianne Bandeira-Melo   +10 more
doaj   +1 more source

The influence of anti-asthma drugs on the transcriptional regulation of chemokine receptor 3 (CCR3) [PDF]

, 2012
Introduction: Chemokine receptor 3 (CCR3), the major chemokine receptor expressed on eosinophils, binds promiscuously to several ligands, mainly the eotaxin family of chemokines which are up-regulated in inflammatory response.
Ellul-Micallef, Roger, 8th Malta Medical School Conference, Grech, Godwin M., Grech, Godfrey, Fenech, Anthony G.   +4 more
core  

Estudi de l'eix CCL11/CCR3 a la lesió ateroscleròtica de ratolins apoE-/- induït per dieta hipercolesterolèmica.

, 2022
[ES] La aterosclerosis es una enfermedad inflamatoria crónica que se caracteriza por la acumulación de lípidos en la capa íntima de las arterias e infiltración de células inflamatorias, y constituye la principal base fisiopatológica de las enfermedades ...
Hernanz Grimalt, Ana
core  

Interplay between signaling via the formyl peptide receptor (FPR) and chemokine receptor 3 (CCR3) in human eosinophils

, 2009
Eosinophils express the chemoattractant receptors CCR3 and FPR. CCR3 binds several agonists such as eotaxin-1, -2, and -3 and RANTES, whereas the FPR binds the formylated tripeptide fMLP and a host of other ligands.
Wennerås, Christine,, Svensson, Lena,, Redvall, Elin,, Johnsson, Marianne, Dahlgren, Claes,, Stenfeldt, Anna-Lena,   +5 more
core   +1 more source

CCR3 is a target for age-related macular degeneration diagnosis and therapy

, 2009
Age-related macular degeneration (AMD), a leading cause of blindness worldwide, is as prevalent as cancer in industrialized nations. Most blindness in AMD results from invasion of the retina by choroidal neovascularisation (CNV).
Wright, John D., Mark E. Kleinman, John D. Wright, Balamurali K. Ambati, Rothenberg, Marc E., Hartnett, M. Elizabeth, Pete Geisen, Green, Martha G., Kleinman, Mark E., Kiyoshi Yamada, Steven J. Budd, Ambati, Balamurali K., Craig J. Gerard, Nozaki, Miho, Alison A. Humbles, Kaneko, Hiroki, Ogura, Yuichiro, Humbles, Alison A., Raisler, Brian J., Miho Nozaki, M. Elizabeth Hartnett, Cho, Won Gil, Sami Dridi, Pan, Yuzhen, Grisanti, Salvatore, Saito, Kuniharu, Gerard, Craig J., Atsunobu Takeda, Romulo J. C. Albuquerque, Judit Z. Baffi, Munitz, Ariel, Ariel Munitz, Won Gil Cho, Kuniharu Saito, Albuquerque, Romulo J. C., Salvatore Grisanti, Baffi, Judit Z., Yuichiro Ogura, Justine R. Smith, Ambati, Jayakrishna, Geisen, Pete, Ishibashi, Tatsuro, Smith, Justine R., Dridi, Sami, Hiroki Kaneko, Takeda, Atsunobu, Marc E. Rothenberg, Jayakrishna Ambati, Tatsuro Ishibashi, Yamada, Kiyoshi, Budd, Steven J., Yuzhen Pan, Martha G. Green, Brian J. Raisler   +53 more
core   +1 more source

The Crucial Role of GATA-1 in CCR3 Gene Transcription: Modulated Balance by Multiple GATA Elements in the CCR3 Regulatory Region

, 2010
GATA-1, a zinc finger-containing transcription factor, regulates not only the differentiation of eosinophils but also the expression of many eosinophil-specific genes.
Tae Gi Uhm, Sin-Hwa Lee, Choon-Sik Park, Byung Soo Kim, Jin Hyun Kang, Il Yup Chung, Seol Kyoung Lee   +6 more
core   +1 more source

Depletion of eosinophils in mice through the use of antibodies specific for C-C chemokine receptor 3 (CCR3)

, 1999
We have generated rat monoclonal antibodies specific for the mouse eotaxin receptor, C-C chemokine receptor 3 (CCR3). Several anti-CCR3 mAbs proved to be useful for in vivo depletion of CCR3-expressing cells and immunofluorescent staining.
Brian W P Seymour, Nancy Hosken, Nai-Xuan Yu, Hortensia Soto, Gabrielle Grunig, Xiaoyan Wu, Maureen C Howard, Douglas S Robinson, Anne O'Garra, Robert L Coffman, J Christopher Grimaldi, Walter G Ferlin, Françoise Cottrez   +12 more
core   +1 more source

CCL28 modulates neutrophil responses during infection with mucosal pathogens

eLife
The chemokine CCL28 is highly expressed in mucosal tissues, but its role during infection is not well understood. Here, we show that CCL28 promotes neutrophil accumulation in the gut of mice infected with Salmonella and in the lung of mice infected with ...
Gregory T Walker, Araceli Perez-Lopez, Steven Silva, Michael H Lee, Elisabet Bjånes, Nicholas Dillon, Stephanie L Brandt, Romana R Gerner, Karine Melchior, Grant J Norton, Felix A Argueta, Frenchesca Dela Pena, Lauren Park, Victor A Sosa-Hernandez, Rodrigo Cervantes-Diaz, Sandra Romero-Ramirez, Monica Cartelle Gestal, Jose L Maravillas-Montero, Sean-Paul Nuccio, Victor Nizet, Manuela Raffatellu   +20 more
doaj   +1 more source

Monocyte chemotactic protein-4 (MCP-4/CCL-13) and CC chemokine receptor 3 (CCR3) in the sputum of asthmatic children

, 2014
Background: Monocyte chemotactic protein-4 (MCP-4/CCL-13) is a potent chemoattractant to eosinophils, monocytes and lymphocytes. Objective: We aimed to investigate MCP-4 and its CC chemokine receptor 3 (CCR3) expression on cells of induced sputum during ...
Awwad, Khaled S, Heshmat, Nahla M, Ezzat, Mohamed H, El-Gabbas, Zeinab M, Abd Al-Aziz, Manal M, El-Gamal, Yehia M   +5 more
core   +1 more source