Results 81 to 90 of about 22,866 (205)

Expression and prognostic significance of CCL11/CCR3 in glioblastoma

Oncotarget, 2016
Glioblastoma (GBM) is the most lethal primary nervous system cancer, but due to its rarity and complexity, its pathogenesis is poorly understood. To identify potential tumorigenic factors in GBM, we screened antibody-based cytokine arrays and found that CCL11 was upregulated.
Tian, Min, Chen, Lina, Ma, Li, Wang, Dandan, Shao, Bin, Wu, Jianyu, Wu, Hangyu, Jin, Yimin   +7 more
openaire   +3 more sources

A small molecule antagonist of chemokine receptors CCR1 and CCR3 - Potent inhibition of eosinophil function and CCR3-mediated HIV-1 entry

, 2000
We describe a small molecule chemokine receptor antagonist, UCB35625 (the trans-isomer J113863 published by Banyu Pharmaceutical Co., patent WO98/04554), which is a potent, selective inhibitor of CCR1 and CCR3.
Simmons, G, Timothy J. Williams, Paul R. Clapham, Michael J. Peck, Annelies Jorritsma, Graham Simmons, Van Keulen, BJ, James E. Pease, Ian Sabroe, Williams, TJ, Peck, MJ, Sabroe, I, Clapham, PR, Berend Jan Van Keulen, Pease, JE, Jorritsma, A   +15 more
core   +1 more source

Basophil FCER1A and PTAFR Gene Expression Profiles Correlate With Disease Severity in Chronic Spontaneous Urticaria

Clinical and Translational Allergy, Volume 16, Issue 4, April 2026.
ABSTRACT Background Chronic Spontaneous Urticaria (CSU) is a debilitating skin condition characterized by recurrent wheals and pruritus, significantly impacting quality of life. Molecular mechanisms underlying different severity phenotypes are not fully understood.
Kevin Muliawan Soetanto, Chattip Sripatumtong, Teerapat Paringkarn, Nattha Angkoolpakdeekul, Kanokvalai Kulthanan, Yuttana Srinoulprasert   +5 more
wiley   +1 more source

The Rhesus Macaque CCR3 Chemokine Receptor Is a Cell Entry Cofactor for HIV-2, but Not for HIV-1

, 1998
The eotaxin receptor (CCR3) is a CD4-associated coreceptor for human immunodeficiency virus type 1 (HIV-1) and type 2 (HIV-2). By comparison with other chemokine receptors, such as CCR5 and CXCR4, the primary sequences of human CCR3 and its rhesus ...
Tréboute, Carole, Shacklett, Barbara, Alizon, Marc, Ferchal, Françoise, Sol, Nathalie, Gomas, Emmanuel   +5 more
core   +1 more source

CCR3 gene overexpression in patients with Down syndrome_Salemi et al._Mol Biol Rep 2021

, 2022
Chromosome 21 trisomy or Down syndrome (DS) is the most common genetic cause of intellectual disability (ID). DS is also associated with hypotonia, muscle weakness, autoimmune diseases, and congenital heart disease.
Oasi Research Institute - IRCCS, D (via Mendeley Data)
core   +1 more source

Method of Using CCR3 Binding Agents to Detect Choroidal Neovascularization

, 2014
The results presented herein demonstrate the specific expression of CCR3 in CNV endothelial cells in humans with AMD, and despite the expression of its ligands, eotaxin-1, -2, and -3, neither eosinophils nor mast cells are present in human CNV.
Ambati, Jayakrishna, Kleinman, Mark E.
core  

A novel membrane based process to isolate recombinant human chemokine receptor CCR3 produced in Escherichia coli

, 2013
The isolation of recombinant human chemokine receptor CCR3, which fused to maltose binding protein (MBP), has been conducted using ultrafiltration with 300. kDa molecular weight cut-off polyethersulfone membranes. The effects of ultrafiltration operating
Liu, Jianguo, Lu, Jianren; id_orcid, Ge, B, Lu, J, Chen, Changzhen, Changzhen Chen, Ge, Baosheng, Jianren Lu, Jianguo Liu, Liu, J, Cui, Zhanfeng, Baosheng Ge, Chen, C, Zhanfeng Cui   +13 more
core   +1 more source

Prevalence and CCR3-T51C genotype–phenotype correlation of bronchial asthma among basic education school children: an observational study

Egyptian Pediatric Association Gazette
Background Bronchial asthma (BA) is a chronic inflammatory disorder identified by different endotypes and phenotypes. Chemokine receptor 3 (CCR3) is one of the essential chemokine receptors that have a crucial role in asthma development by activating the
Magdy Zedan, Mona Elwassefy, Ismail El Zareif, Hossam ElTahan, Yahya Wahba   +4 more
doaj   +1 more source

A Novel CC-Chemokine Receptor 3 Antagonist, Ki19003, Inhibits Airway Eosinophilia and Subepithelial/Peribronchial Fibrosis Induced by Repeated Antigen Challenge in Mice

Journal of Pharmacological Sciences, 2010
CC-chemokine receptor 3 (CCR3) is a chemokine receptor for which major ligands, CC-chemokine ligand (CCL) 11, CCL24, and CCL26, are known to be involved in chemotaxis for eosinophils.
Masato Komai, Hiroyuki Tanaka, Koichi Nagao, Masayuki Ishizaki, Daisuke Kajiwara, Toru Miura, Hiroshi Ohashi, Tomoko Haba, Kazuki Kawakami, Eiji Sawa, Osamu Yoshie, Naoki Inagaki, Hiroichi Nagai   +12 more
doaj   +1 more source

Peran Kemokin dalam Patogenesis Rinitis Alergi

Jurnal Kesehatan Andalas, 2014
AbstrakLatar belakang: Rinitis alergi merupakan penyakit dengan insiden yang cukup tinggi diseluruh dunia dengan prevalensi yang semakin meningkat setiap tahun. Patogenesis rinitis alergi melibatkan reaksi imun yang cukup komplek.
Effy Huriyati, Bestari J Budiman, Ricki Octiza   +2 more
doaj