Results 161 to 170 of about 22,866 (205)

Upregulated expression of CCR3 in rheumatoid arthritis and CCR3-dependent activation of fibroblast-like synoviocytes

Cell Biology and Toxicology, 2016
It is recognized that CC chemokine receptor 3 (CCR3) is associated with numerous inflammatory conditions and fibroblast-like synoviocyte (FLS) invasiveness correlates with articular damage in rheumatoid arthritis (RA). However, little is known of the expression and action of CCR3 on FLS in RA.
Huiyun Zhang, Junling Wang, Shaoheng He   +2 more
exaly   +3 more sources

Pyrrolidinohydroquinazolines––a novel class of CCR3 modulators

Bioorganic and Medicinal Chemistry Letters, 2005
AbstractFor Abstract see ChemInform Abstract in Full Text.
Ralf, Anderskewitz, Rolf, Bauer, Gisela, Bodenbach, Dirk, Gester, Bernd, Gramlich, Gerd, Morschhäuser, Franz W, Birke   +6 more
exaly   +3 more sources

Differential Regulation of Eosinophil Chemokine Signaling Via CCR3 and Non-CCR3 Pathways

The Journal of Immunology, 1999
Abstract To investigate eosinophil stimulation by chemokines we developed a sensitive assay of leukocyte shape change, the gated autofluorescence/forward scatter assay. Leukocyte shape change responses are mediated through rearrangements of the cellular cytoskeleton in a dynamic process typically resulting in a polarized cell and are ...
I, Sabroe, A, Hartnell, L A, Jopling, S, Bel, P D, Ponath, J E, Pease, P D, Collins, T J, Williams   +7 more
openaire   +2 more sources

Small molecule antagonists for chemokine CCR3 receptors

Medicinal Research Reviews, 2010
AbstractThe chemokine receptor CCR3 is believed to play a role in the development of allergic diseases such as asthma, atopic dermatitis, and allergic rhinitis. Despite the conflicting results that have been reported regarding the importance of eosinophils and CCR3 in allergic inflammation, inhibition of this receptor with small molecule antagonists is
Lianne I Willems, Adriaan P Ijzerman
exaly   +3 more sources

Chemokine CCR3 antagonists

Expert Opinion on Therapeutic Patents, 2004
Because CC chemokine receptor 3 (CCR3) expression is confined to eosinophils, and such leukocytes play an important role in allergic disorders, identification of CCR3 antagonists represents a logical approach to identifying new treatments for eosinophil-associated inflammatory disorders such as asthma.
Akira Naya, Toshihiko Saeki
openaire   +1 more source

Design and Synthesis of Novel CCR3 Antagonists.

ChemInform, 2003
AbstractFor Abstract see ChemInform Abstract in Full Text.
Leyi, Gong, J Heather, Hogg, James, Collier, Robert S, Wilhelm, Carol, Soderberg   +4 more
openaire   +2 more sources

Identification of a Potent and Nonpeptidyl CCR3 Antagonist

Biochemical and Biophysical Research Communications, 2001
CCR3 is expressed in a variety of leukocyte subsets, especially eosinophils, and may be involved in allergic disorders such as atopic asthma. To clarify the pathophysiological roles of CCR3 in allergic disorders, we developed a nonpeptidyl CCR3 antagonist.
Toshihiko Saeki, Kenji Ohwaki, Norikazu Ohtake   +2 more
exaly   +3 more sources

Aminooxypentane-RANTES Induces CCR3 Activation and Internalization of CCR3 from the Surface of Human Eosinophils

International Archives of Allergy and Immunology, 2001
Eosinophils are predominant effector cells in allergic diseases attracted by several CC chemokines into the inflammatory tissue. According to their important role in attracting leukocytes, several kinds of chemokine receptor antagonists have been developed.
J, Elsner, Y, Dulkys, D, Kimmig, T N, Wells, A E, Proudfoot, A, Kapp   +5 more
openaire   +2 more sources

CCR3 antagonists: a survey of the patent literature

Expert Opinion on Therapeutic Patents, 2009
Since the mid-1990s, there has been significant effort invested in the discovery and clinical development of CC chemokine receptor-3 (CCR3) antagonists as potential therapeutics for airway disease.A patent literature review is presented of small molecule CCR3 antagonists comprising the years 2004 to the present. The patent searches were conducted using
Leyi, Gong, Robert S, Wilhelm
openaire   +2 more sources

Discovery of a novel CCR3 selective antagonist

Bioorganic & Medicinal Chemistry Letters, 2001
In searching for a novel CCR3 receptor antagonist, we designed a library that included a variety of carboxamide derivatives based on the structure of our potent antagonists for human CCR1 and CCR3 receptors, and screened the new compounds for inhibitory activity against 125I-Eotaxin binding to human CCR3 receptors expressed in CHO cells.
A, Naya, K, Kobayashi, M, Ishikawa, K, Ohwaki, T, Saeki, K, Noguchi, N, Ohtake   +6 more
openaire   +2 more sources