Results 171 to 180 of about 22,866 (205)

CCR3 gene overexpression in patients with Down syndrome

Molecular Biology Reports, 2021
Chromosome 21 trisomy or Down syndrome (DS) is the most common genetic cause of intellectual disability (ID). DS is also associated with hypotonia, muscle weakness, autoimmune diseases, and congenital heart disease. C-C chemokine receptor type 3 (CCR3) plays a role in inflammatory, autoimmune, and neuronal migration mechanisms.
Salemi M., Cannarella R., Marchese G., Salluzzo M. G., Ravo M., Barone C., Cordella A., Caniglia S., Castiglione R., Ragalmuto A., Calogero A. E., Romano C.   +11 more
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CCR3 blockade as a new therapy for asthma

Expert Opinion on Investigational Drugs, 2000
Among the inflammatory cells infiltrating the lungs of asthmatic patients, eosinophils and Th2 cells are thought to play a central role in the pathogenesis of this disease. Several studies have implicated that chemokines are prime candidates for being responsible for the selective recruitment of the leukocyte subsets found in atopic diseases. Regulated
C P, Bertrand, P D, Ponath
openaire   +2 more sources

A polymorphism in CCR1/CCR3 is associated with narcolepsy

Brain, Behavior, and Immunity, 2015
Etiology of narcolepsy-cataplexy involves multiple genetic and environmental factors. While the human leukocyte antigen (HLA)-DRB1*15:01-DQB1*06:02 haplotype is strongly associated with narcolepsy, it is not sufficient for disease development. To identify additional, non-HLA susceptibility genes, we conducted a genome-wide association study (GWAS ...
Hiromi Toyoda, Taku Miyagawa, Asako Koike, Takashi Kanbayashi, Aya Imanishi, Yohei Sagawa, Nozomu Kotorii, Tatayu Kotorii, Yuji Hashizume, Kimihiro Ogi, Hiroshi Hiejima, Yuichi Kamei, Akiko Hida, Masayuki Miyamoto, Makoto Imai, Yota Fujimura, Yoshiyuki Tamura, Azusa Ikegami, Yamato Wada, Shunpei Moriya, Hirokazu Furuya, Masaki Takeuchi, Yohei Kirino, Akira Meguro, Elaine F Remmers, Yoshiya Kawamura, Takeshi Otowa, Akinori Miyashita, Koichi Kashiwase, Seik-Soon Khor, Maria Yamasaki, Ryozo Kuwano, Tsukasa Sasaki, Jun Ishigooka, Kenji Kuroda, Kazuhiko Kume, Shigeru Chiba, Naoto Yamada, Masako Okawa, Koichi Hirata, Nobuhisa Mizuki, Naohisa Uchimura, Tetsuo Shimizu, Yuichi Inoue, Yutaka Honda, Kazuo Mishima, Makoto Honda, Katsushi Tokunaga   +47 more
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Distribution of CCR3 mRNA expression in horse tissues

Veterinary Immunology and Immunopathology, 2006
CCL11 (also known as eotaxin) is a very potent and selective mediator of eosinophil migration which exerts its effects through its receptor, CCR3. In this study we report the cloning of an equine CCR3 cDNA sequence and investigation of the localization of CCR3 mRNA expression in horse tissues. Equine CCR3 displayed high levels of sequence identity with
Fiona M Cunningham
exaly   +3 more sources

Stereoselective Process for a CCR3 Antagonist

Organic Process Research & Development, 2006
A convergent, multikilogram, stereoselective synthesis of 1 is described. A key fragment, (S)-3-(4-fluorobenzyl)piperidine (2) was synthesized from valerolactam in three steps using our recently discovered Ir−BDPP-catalyzed asymmetric hydrogenation. Another key fragment, (1R,2R)-2-(benzyloxycarbonylamino)cyclohexanecarboxaldehyde (3) was synthesized ...
Tai-Yuen Yue, Douglas D. McLeod, Kevin B. Albertson, Steven R. Beck, Joerg Deerberg, Joseph M. Fortunak, William A. Nugent, Lilian A. Radesca, Liya Tang, Cathie Dong Xiang   +9 more
openaire   +1 more source

Involvement of CCR3-Reactive Chemokines in Eosinophil Survival

International Archives of Allergy and Immunology, 2003
<i>Background:</i> Although eosinophils undergo apoptosis and are thus eliminated from sites of inflammation, they survive longer if survival factors, such as IL-3, IL-5 and GM-CSF, are present. However, it is often observed that some eosinophils survive even when incubated without any survival factors (spontaneous survival). The aim of the
Kazuhiko, Shinagawa, Alexandre, Trifilieff, Gary P, Anderson   +2 more
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Pyrrolidinyl phenylurea derivatives as novel CCR3 antagonists

Bioorganic & Medicinal Chemistry Letters, 2012
Optimization starting with our lead compound 1 (IC(50)=4.9 nM) led to the identification of pyrrolidinyl phenylurea derivatives. Further modification toward improvement of the bioavailability provided (R)-1-(1-((6-fluoronaphthalen-2-yl)methyl)pyrrolidin-3-yl)-3-(2-(2-hydroxyethoxy)phenyl)urea 32 (IC(50)=1.7 nM), a potent and orally active CCR3 ...
Aiko, Nitta, Yosuke, Iura, Hideki, Inoue, Ippei, Sato, Koichiro, Morihira, Hirokazu, Kubota, Tatsuaki, Morokata, Makoto, Takeuchi, Mitsuaki, Ohta, Shin-ichi, Tsukamoto, Takayuki, Imaoka, Toshiya, Takahashi   +11 more
openaire   +2 more sources

Expression of the Chemokine Receptor CCR3 on Human Mast Cells

International Archives of Allergy and Immunology, 2001
<i>Background:</i> The aim of this study was to investigate whether human mast cells express functional active CCR3 receptors, which are activated by CC chemokines. These ligands include the CCR3-selective chemokines eotaxin and eotaxin-2 and the more promiscuous CC chemokines, MCP-4, MCP-3, MCP-2 and RANTES.
A. DE PAOLIS, ANNUNZIATO, FRANCESCO, L. DI GIOIA, ROMAGNANI, SERGIO, M. CANFORA, C. BELTRAME, G. MARONE, ROMAGNANI, PAOLA   +7 more
openaire   +4 more sources

CCR3

American Journal of Respiratory Cell and Molecular Biology, 2003
Paul Forsythe, A. Dean Befus
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Synthesis of a CCR3 Antagonist

Synfacts, 2006
T.-Y. Yue, D. McLeod, K. Albertson, S. Beck, J. Deerberg, J. Fortunak, W. Nugent, L. Radesca, L. Tang, C. Xiang   +9 more
openaire   +1 more source