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The CCR4–NOT complex maintains liver homeostasis through mRNA deadenylation

The CCR4–NOT complex maintains liver homeostasis through mRNA deadenylation
The biological significance of deadenylation in global gene expression is not fully understood. Here, we show that the CCR4-NOT deadenylase complex maintains expression of mRNAs, such as those encoding transcription factors, cell cycle regulators, DNA damage response-related proteins, and metabolic enzymes, at appropriate levels in the liver.
openaire  

Targeting the neuro-immune crosstalk in breast cancer brain metastases. [PDF]

J Immunother Cancer
Zou Y, Wu J, Yuan Z, He X, Tang H.
europepmc   +1 more source

Inflammatory Mediators of Alzheimer's Disease Characterized in a Mouse Model (APP/PS1). [PDF]

NeuroSci
Jorda A, Alvarez-Gamez K, Campo-Palacio I, Campos-Campos J, Colmena C, Singh SK, Miralles MJC, Aldasoro C, Aldasoro M, Valles SL.   +9 more
europepmc   +1 more source

CCL2: A double-edged sword in neuroblastoma, with a critical role in MYCN-amplified tumors. [PDF]

Transl Oncol
Jannot L, Gazeu A, Bendriss-Vermare N, Pochon C, Sartelet H.   +4 more
europepmc   +1 more source

CXCR3/CXCL10 Axis-Mediated T Cell Infiltration in the Lungs of Patients With HTLV-1-Associated Diseases: Implications for Subclinical Pulmonary Involvement. [PDF]

J Med Virol
Tsuchimoto K, Mori A, Tanaka M, Arishima S, Kodama D, Dozono M, Nozuma S, Takashima H, Kubota R.   +8 more
europepmc   +1 more source

Reference Intervals for Lymphocyte Subpopulations in Healthy Chinese Han Adults: A Single-Center Study. [PDF]

J Clin Lab Anal
Jiang AN, Miao LZ, Gong Y, You R, Lu Y, Qu CX.   +5 more
europepmc   +1 more source

"Control of protein quality and stoichiometries by N-terminal acetylation and the N-end rule pathway" [PDF]

, 2013
Lyon, Gholson J.
core  

Identification of novel small ncRNAs in pollen of tomato [PDF]

core   +1 more source

Regulatory T Cell Heterogeneity in the Steady State and Tumor. [PDF]

Immune Netw
Kim D, Lee N, Ha SJ.
europepmc   +1 more source

Discovery of Drug-like Inhibitors of the Human Caf1/CNOT7 poly(A)-Selective Nuclease Using Compound Screening. [PDF]

Biomolecules
Kaur I, Hashmi L, Fischer PM, Winkler GS.   +3 more
europepmc   +1 more source