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Structure and assembly of the NOT module of the human CCR4–NOT complex
Nature Structural & Molecular Biology, 2013The CCR4-NOT deadenylase complex is a master regulator of translation and mRNA stability. Its NOT module orchestrates recruitment of the catalytic subunits to target mRNAs. We report the crystal structure of the human NOT module formed by the CNOT1, CNOT2 and CNOT3 C-terminal (-C) regions.
Andreas Boland +7 more
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Carbon source dependent dynamics of the Ccr4-Not complex in Saccharomyces cerevisiae
The Journal of Microbiology, 2008We have investigated the composition of the conserved Ccr4-Not complex during different physiological states of Saccharomyces cerevisiae. Major changes were found, most notably in the expression of the central scaffold protein Not1p, which was strongly reduced in the absence of glucose. The low expression of Not1p was also evident from the inability of
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PABP Cooperates with the CCR4-NOT Complex to Promote mRNA Deadenylation and Block Precocious Decay
Molecular Cell, 2018Joha Park, Minju Ha, Jaechul Lim
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DND1 maintains germline stem cells via recruitment of the CCR4–NOT complex to target mRNAs
Nature, 2017Masashi Yamaji +2 more
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Multifunctional roles of the mammalian CCR4–NOT complex in physiological phenomena
Frontiers in Genetics, 2014Yo-taro Shirai +2 more
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Human Ccr4-Not complex is a ligand-dependent repressor of nuclear receptor-mediated transcription
EMBO Journal, 2006Klaas W Mulder +2 more
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