Results 161 to 170 of about 15,618 (178)
C2ORF29/CNOT11 and CNOT10 form a new module of the CCR4-NOT complex
RNA Biology, 2013 The CCR4-NOT complex was originally identified and its composition and organization characterized in the yeast Saccharomyces cerevisiae. It was first suggested to participate in transcription regulation, but since then it has become clear that it plays a
Bertrand Séraphin, Fabienne Mauxion
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Novel roles of the
The CCR4–NOT complex is a multi‐subunit protein complex evolutionarily conserved across eukaryotes which regulates several aspects of gene expression. A fascinating model is emerging in which this complex acts as a regulation platform, controlling gene products ‘from birth to death’ through the coordination of different cellular machineries involved in
Clément, Chapat, Laura, Corbo
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Global control of gene expression in yeast by the Ccr4-Not complex
Gene, 2003The Ccr4-Not complex is a global regulator of gene expression that is conserved from yeast to human. It is a large complex that in the yeast Saccharmyces cerevisiae exists in two prominent forms of 0.9-1.2 and 1.9-2 MDa, and consists of at least nine core subunits: the five Not proteins (Not1p to Not5p), Caf1p, Caf40p, Caf130p and Ccr4p.
Martine A Collart
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Structure and assembly of the NOT module of the human CCR4–NOT complex
Nature Structural & Molecular Biology, 2013The CCR4-NOT deadenylase complex is a master regulator of translation and mRNA stability. Its NOT module orchestrates recruitment of the catalytic subunits to target mRNAs. We report the crystal structure of the human NOT module formed by the CNOT1, CNOT2 and CNOT3 C-terminal (-C) regions.
Andreas Boland +7 more
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Deadenylation of cytoplasmic mRNA by the mammalian Ccr4–Not complex
Biochemical Society Transactions, 2012The Ccr4–Not complex is one of the major deadenylase factors present in eukaryotic cells. This multi-subunit protein complex is composed of at least seven stably associated subunits in mammalian cells including two enzymatic deadenylase subunits: one DEDD (Asp-Glu-Asp-Asp)-type deadenylase (either CNOT7/human Caf1/Caf1a or CNOT8/human Pop2/Caf1b/Calif)
Rachel, Doidge +3 more
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Dissecting the Role of the Ccr4–Not Deadenylase Complex in Pluripotency and Differentiation
2023In this chapter, we describe methods and assays to examine the role of the Ccr4-Not mRNA deadenylase complex in regulating mouse embryonic stem cell (ESC) pluripotency and differentiation. We present the following procedures: sgRNA design and cloning, the culture of mouse ESCs, transfection and colony picking, genotyping, generation of Cnot3 ...
Xiukun, Wang +3 more
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The CCR4–NOT Complex Plays Diverse Roles in mRNA Metabolism
2003It is increasingly clear that the synthesis of eukaryotic mRNA involves an integrated series of events involving large multisubunit protein complexes. The evolutionarily conserved CCR4-NOT complex of proteins has been found to be involved in several aspects of mRNA formation, including repression and activation of mRNA initiation, control of mRNA ...
Clyde L, Denis, Junji, Chen
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Insights into the structure of the CCR4-NOT complex by electron microscopy
FEBS Letters, 2011Bettina Böttcher +2 more
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