Thermosensitivity of cellular translation restricts the growth of fission yeast at high temperatures. [PDF]
Commun BiolAkikusa Y +10 more
europepmc +1 more source
CNOT10 is involved in TTP-mediated AU-rich element containing mRNA metabolism, independent of mRNA decay regulation. [PDF]
RNAArao Y, Williams JG, Lai WS.
europepmc +1 more source
Degradation factor 1, Def1, regulates mRNA translation and decay through Ccr4-Not-dependent ubiquitylation of the ribosome. [PDF]
RNAAkinniyi OT +4 more
europepmc +1 more source
Insights into the structure of the CCR4-NOT complex by electron microscopy [PDF]
FEBS Letters, 2011 The CCR4-NOT complex is a deadenylation complex, which plays a major role for mRNA stability. The complex is conserved from yeast to human and consists of nine proteins NOT1-NOT5, CCR4, CAF1, CAF40 and CAF130. We have successfully isolated the complex using a Protein A tag on NOT1, followed by cross-linking on a glycerol gradient. All components of the
Claire Batisse +2 more
exaly +6 more sources
The control of elongation by the yeast Ccr4–Not complex [PDF]
Biochimica Et Biophysica Acta - Gene Regulatory Mechanisms, 2013 The Ccr4-Not complex is a highly conserved nine-subunit protein complex that has been implicated in virtually all aspects of gene control, including transcription, mRNA decay and quality control, RNA export, translational repression and protein ubiquitylation.
Joseph C Reese
exaly +3 more sources
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Novel interaction between CCR4 and CAF1 in rice CCR4–NOT deadenylase complex
Plant Molecular Biology, 2016Rice is an important crop in the world. However, little is known about rice mRNA deadenylation, which is an important regulation step of gene expression at the post-transcriptional level. The CCR4-NOT1 complex contains two key components, CCR4 and CAF1, which are the main cytoplasmic deadenylases in eukaryotic cells.
Chung-An Lu, Lu Chung-An
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Ccr4-Not complex: the control freak of eukaryotic cells [PDF]
Critical Reviews in Biochemistry and Molecular Biology, 2012 The purpose of this review is to provide an analysis of the latest developments on the functions of the carbon catabolite-repression 4-Not (Ccr4-Not) complex in regulating eukaryotic gene expression. Ccr4-Not is a nine-subunit protein complex that is conserved in sequence and function throughout the eukaryotic kingdom.
Jason E Miller, Joseph C Reese
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Novel roles of the
The CCR4–NOT complex is a multi‐subunit protein complex evolutionarily conserved across eukaryotes which regulates several aspects of gene expression. A fascinating model is emerging in which this complex acts as a regulation platform, controlling gene products ‘from birth to death’ through the coordination of different cellular machineries involved in
Clément, Chapat, Laura, Corbo
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Structure and assembly of the NOT module of the human CCR4–NOT complex
Nature Structural & Molecular Biology, 2013The CCR4-NOT deadenylase complex is a master regulator of translation and mRNA stability. Its NOT module orchestrates recruitment of the catalytic subunits to target mRNAs. We report the crystal structure of the human NOT module formed by the CNOT1, CNOT2 and CNOT3 C-terminal (-C) regions.
Andreas Boland +7 more
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Global control of gene expression in yeast by the Ccr4-Not complex
Gene, 2003The Ccr4-Not complex is a global regulator of gene expression that is conserved from yeast to human. It is a large complex that in the yeast Saccharmyces cerevisiae exists in two prominent forms of 0.9-1.2 and 1.9-2 MDa, and consists of at least nine core subunits: the five Not proteins (Not1p to Not5p), Caf1p, Caf40p, Caf130p and Ccr4p.
Martine A Collart
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