Results 151 to 160 of about 15,618 (178)

The CCR4–NOT Deadenylase Complex Maintains Adipocyte Identity

The CCR4–NOT Deadenylase Complex Maintains Adipocyte Identity
Shortening of poly(A) tails triggers mRNA degradation; hence, mRNA deadenylation regulates many biological events. In the present study, we generated mice lacking the Cnot1 gene, which encodes an essential scaffold subunit of the CCR4–NOT deadenylase complex in adipose tissues (Cnot1-AKO mice) and we examined the role of CCR4–NOT in adipocyte function.
openaire   +1 more source

Drosophila Bag-of-marbles directly interacts with the CAF40 subunit of the CCR4-NOT complex to elicit repression of mRNA targets. [PDF]

RNA, 2018
Sgromo A, Raisch T, Backhaus C, Keskeny C, Alva V, Weichenrieder O, Izaurralde E.   +6 more
europepmc   +1 more source

CNOT11 depletion is associated with autophagy-related responses and IL-6-JAK-STAT signaling in cancer cells. [PDF]

Front Cell Dev Biol
Nishijima S, Suzuki T, Yamamoto T.
europepmc   +1 more source

CNOT10 is involved in the TTP-mediated AU-rich element-containing mRNA metabolism, independent of mRNA decay regulation. [PDF]

RNA
Arao Y, Williams JG, Lai WS.
europepmc   +1 more source

Thermosensitivity of cellular translation restricts the growth of fission yeast at high temperatures. [PDF]

Commun Biol
Akikusa Y, Yamaguchi A, Funahashi Y, Tan ACW, Mahayot F, Naka T, Matsuo A, Nakase Y, Izawa S, Shiozaki K, Morozumi Y.   +10 more
europepmc   +1 more source

CCR4-NOT is required for suppressing pervasive transcription and retrotransposable elements. [PDF]

J Biol Chem
Kulkarni SD, Morrissey A, Sebastian A, Akinniyi OT, Keller CA, Albert I, Mahony S, Reese JC.   +7 more
europepmc   +1 more source

Purification and characterization of the 1.0 MDa CCR4-NOT complex identifies two novel components of the complex [PDF]

Journal of Molecular Biology, 2001
The CCR4-NOT complex is an evolutionarily conserved, transcriptional regulatory complex that is involved in controlling mRNA initiation, elongation and degradation.
Juri Rappsilber, Pamela Russell, Clyde L Denis   +2 more
exaly   +6 more sources

The control of elongation by the yeast Ccr4–Not complex [PDF]

Biochimica Et Biophysica Acta - Gene Regulatory Mechanisms, 2013
The Ccr4-Not complex is a highly conserved nine-subunit protein complex that has been implicated in virtually all aspects of gene control, including transcription, mRNA decay and quality control, RNA export, translational repression and protein ubiquitylation.
Joseph C Reese
exaly   +3 more sources

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Novel interaction between CCR4 and CAF1 in rice CCR4–NOT deadenylase complex

Plant Molecular Biology, 2016
Rice is an important crop in the world. However, little is known about rice mRNA deadenylation, which is an important regulation step of gene expression at the post-transcriptional level. The CCR4-NOT1 complex contains two key components, CCR4 and CAF1, which are the main cytoplasmic deadenylases in eukaryotic cells.
Chung-An Lu
exaly   +3 more sources

Ccr4-Not complex: the control freak of eukaryotic cells [PDF]

Critical Reviews in Biochemistry and Molecular Biology, 2012
The purpose of this review is to provide an analysis of the latest developments on the functions of the carbon catabolite-repression 4-Not (Ccr4-Not) complex in regulating eukaryotic gene expression. Ccr4-Not is a nine-subunit protein complex that is conserved in sequence and function throughout the eukaryotic kingdom.
Jason Miller, Joseph C Reese
exaly   +3 more sources