Results 131 to 140 of about 24,702 (192)

Monovalent mannose‐glycoconjugates of sulforaphane reprogram human dendritic cells via NFATc1 to induce immune tolerance under inflammatory conditions

British Journal of Pharmacology, Volume 183, Issue 9, Page 1993-2008, May 2026.
Abstract Background and Purpose Immune tolerance prevents inflammation and autoimmunity, with dendritic cells (DCs) playing a key role. Reprogramming DCs towards a tolerogenic state represents a promising therapeutic strategy. Sulforaphane (SFN) has known immunomodulatory effects, but its clinical application is limited by poor stability and ...
María Elena Angarita‐Planchez, Camila Leiva‐Castro, Ana M. Múnera‐Rodríguez, Macarena Martínez‐Bailén, Ana T. Carmona, Soledad López‐Enríquez, Francisca Palomares   +6 more
wiley   +1 more source

Immunotherapy for Esophageal Squamous Cell Carcinoma [PDF]

, 2017
Esophageal squamous cell carcinoma have been frustrating to treat, with slow progress made on extending survival. Immunotherapy targeting immune checkpoints, T cells, and infiltrating lymphocytes has shown promise in early studies.
Takashi Kojima, Toshihiko Doi
core   +1 more source

From Development to Aging: Dynamic Roles of the Thymic Medulla in T Cell Biology

Immunological Reviews, Volume 339, Issue 1, May 2026.
ABSTRACT The thymic medulla is essential for establishing central tolerance, orchestrating the development of a diverse yet self‐tolerant T cell repertoire, and preventing autoimmunity. This process is primarily mediated through interactions between developing thymocytes and antigen‐presenting cells, including thymic epithelial cells (TECs) and ...
Christina Michalaki, Minahil Sharjeel, Jennifer E. Cowan   +2 more
wiley   +1 more source

Dissecting the Cell‐Type‐Specific Response to an Emerging Tobamovirus in Tomato Reveals Cultivar‐Dependent Involvement of Brassinosteroid Signalling

Plant Biotechnology Journal, Volume 24, Issue 5, Page 3106-3124, May 2026.
ABSTRACT Plant viruses drive widespread crop epidemics, yet the host plant responses across different cell types, particularly how these responses are influenced by cultivars with varying genetic backgrounds, including the presence of resistance (R) genes, remain poorly understood. Using tomato brown rugose fruit virus (ToBRFV) and two tomato cultivars,
Yuhong Zhang, Shan Bu, Yuxin Nie, Luyou Wang, Jiayi Liu, Junchen Xu, Jiejun Peng, Fei Yan, Jian Wu   +8 more
wiley   +1 more source

GWAS identifies regulators of seed and leaf morphology in common bean, revealing OFP5 as a major seed size determinant

The Plant Journal, Volume 126, Issue 3, May 2026.
Significance Statement Seed and leaf phenomic traits, including morphology and spectral features, play key roles in consumer preference and plant performance. Here, we conducted a genome‐wide association study of 71 phenomic traits, identifying 73 high‐confidence quantitative trait locus and 114 candidate genes.
Julia von Steimker, Mustafa Bulut, Gregory Pozhvanov, Susan Bergmann, Regina Wendenburg, Yuming Sun, Feng Zhu, Alice Pieri, Giulia Frascarelli, Laura Nanni, Elisa Bellucci, Elena Bitocchi, Roberto Papa, Alisdair R. Fernie, Saleh Alseekh   +14 more
wiley   +1 more source

Multivalent interactions with CCR4–NOT and PABPC1 determine mRNA repression efficiency by tristetraprolin

Nature Communications
Tristetraprolin family of proteins regulate mRNA stability by binding to specific AU-rich elements in transcripts. This binding promotes the shortening of the mRNA poly(A) tail, or deadenylation, initiating mRNA degradation.
Filip Pekovic, Wi S. Lai, Joshua Corbo, Stephanie N. Hicks, Keiko Luke, Perry J. Blackshear, Eugene Valkov   +6 more
doaj   +1 more source

Roles of the CCR4-Not complex in translation and dynamics of co-translation events. [PDF]

Wiley Interdiscip Rev RNA, 2023
Collart MA, Audebert L, Bushell M.
europepmc   +1 more source

A dual, catalytic role for the fission yeast Ccr4-Not complex in gene silencing and heterochromatin spreading. [PDF]

Genetics, 2023
Challal D, Menant A, Goksal C, Leroy E, Al-Sady B, Rougemaille M.   +5 more
europepmc   +1 more source

CCR4-NOT Complex 2-A Cofactor in Host Cell for Porcine Epidemic Diarrhea Virus Infection. [PDF]

Genes (Basel), 2022
Wang J, Liu H, Yin D, Zhou M, Yin L, Yang Y, Guo Z, Shen X, Dai Y, Shi S, Xie S, Zhao R, Zhou X, Hu X, Hou H, Wang C, Pan X.   +16 more
europepmc   +1 more source

Bidirectional roles of the Ccr4-Not complex in regulating autophagy before and after nitrogen starvation. [PDF]

Autophagy, 2023
Yin Z, Zhang Z, Lei Y, Klionsky DJ.
europepmc   +1 more source