Results 121 to 130 of about 24,702 (192)

The role of RNA Polymerase II-dependent transcription elongation in the cross-talk between mRNA synthesis and decay. [PDF]

, 2018
The main molecule in gene expression is messenger RNA (mRNA) which transfers the information contained in genes in the nucleus to the cytoplasm where it is translated into proteins that carry out cellular functions. mRNA levels are determined through its
Begley, Victoria Sarah
core  

RNA Modifications: Current Understandings and Future Perspectives

MedComm, Volume 7, Issue 5, May 2026.
Types of RNA modification. We have summarized the currently common types of RNA modifications, including ac4C, m6A, m1A, m5C, m3C, m7G, and ψ, and visually characterized their features through structural formulas. The characteristic structures are marked with a background color different from the background color.
Shiyu Xiao, Tingwen Xiang, Chuan Yang, Xiaohua Wang, Gang Huang, Fei Luo, Zhao Xie, Yueqi Chen   +7 more
wiley   +1 more source

Targeting EZH2 Reprograms Intratumoral Regulatory T Cells to Enhance Cancer Immunity. [PDF]

, 2018
Regulatory T cells (Tregs) are critical for maintaining immune homeostasis, but their presence in tumor tissues impairs anti-tumor immunity and portends poor prognoses in cancer patients.
Abnousian, Arbi, Bluestone, Jeffrey A, DuPage, Michel, Fong, Lawrence, Harwin, Tory, Mahuron, Kelly, Pagani, Massimiliano, Pai, Chien-Chun, Quiros, Jason, Ranzani, Valeria, Rosenblum, Michael D, Silveria, Stephanie, Van Gool, Frederic, Wang, David, Young, Arabella   +14 more
core   +2 more sources

Innate Lymphoid Cells in Tissue Homeostasis and Diseases

MedComm, Volume 7, Issue 5, May 2026.
Innate lymphoid cells (ILCs) are a heterogeneous group of immune cells with phenotypic and functional plasticity. ILCs dynamically regulate various immune cell types and play a crucial role in the pathophysiological processes of specific organs during sepsis. Targeting ILCs is a promising strategy for treating sepsis.
Zhenzhen Zhan, Heyang Sun, Chenning Li, Qianya Hong, Shuainan Zhu, Ying Yu, Hao Zhang, Kefang Guo   +7 more
wiley   +1 more source

HELZ directly interacts with CCR4–NOT and causes decay of bound mRNAs

Life Science Alliance, 2019
The putative UPF1-like SF1 helicase HELZ directly interacts with the CCR4–NOT deadenylase complex to induce translational repression and 5′-to-3′ decay of bound mRNAs. Eukaryotic superfamily (SF) 1 helicases have been implicated in various aspects of RNA
Aoife Hanet, Felix Räsch, Ramona Weber, Vincenzo Ruscica, Maria Fauser, Tobias Raisch, Duygu Kuzuoğlu-Öztürk, Chung-Te Chang, Dipankar Bhandari, Cátia Igreja, Lara Wohlbold   +10 more
doaj   +1 more source

Irradiation to Improve the Response to Immunotherapeutic Agents in Glioblastomas. [PDF]

, 2019
PurposeGlioblastoma (GBM) remains an incurable disease despite extensive treatment with surgical resection, irradiation, and temozolomide. In line with many other forms of aggressive cancers, GBM is currently under consideration as a target for ...
Kaprealian, Tania, Lee, Mi-Heon, McBride, William H, Nesseler, Jean Philippe, Nickers, Philippe, Niclou, Simone P, Schaue, Dorthe   +6 more
core  

A Botanical Mixture of Boswellia serrata, Commiphora myrrha, Propolis and Scutellaria baicalensis Reduces Expression of Inflammatory Chemokines in Canine Keratinocytes In Vitro

Veterinary Medicine and Science, Volume 12, Issue 3, May 2026.
YSK‐AB, a botanical mixture, reduced nitric oxide production in RAW 264.7 cells and chemokine expression in canine keratinocytes, suggesting its potential as a natural therapeutic agent for inflammatory skin diseases in dogs. ABSTRACT Background Botanical ingredients can function as adjunctive therapies for managing inflammatory skin diseases ...
Danbee Ha, Kyungsook Jung, Hyungyeong Choi, Ji‐Seon Yoon   +3 more
wiley   +1 more source

Post-transcriptional control of tumor cell autonomous metastatic potential by the CCR4-NOT deadenylase CNOT7 [PDF]

, 2016
Accumulating evidence supports the role of an aberrant transcriptome as a driver of metastatic potential. Deadenylation is a general regulatory node for post-transcriptional control by microRNAs and other determinants of RNA stability.
A Aslam, A Boland, A Charlesworth, A Suzuki, A Yamashita, AM Zubiaga, AP Petit, B Loh, C Chen, CJ Aslakson, CJ Decker, CT Guy, E Wahle, EE Schadt, EJ Chesler, F Faraji, F Faraji, Farhoud Faraji, G. Sebastian Winkler, GS Winkler, H Sandler, Howard H. Yang, I Behm-Ansmant, IJ Fidler, J Van Etten, J Yang, K Ito, K Ito, K Ogami, K Ryan, Kent W. Hunter, KJ Luzzi, L Lukes, L Ma, Laura Corbo, M Fenger-Gron, M Horiuchi, M Maekawa, M Ringner, M Tucker, MA Collart, MA Collart, Markus Hafner, Maxwell P. Lee, MW Helms, N Hosoda, NC Lau, NP Crawford, P Viswanathan, RP Wharton, S Jayne, S Matsuda, S Mittal, S Valastyan, SA Mani, SF Tavazoie, SF Winter, T Lifsted, T Nakamura, TK Albert, W Joly, X Li, X Zheng, XF Pei, Y Funakoshi, Ying Hu   +65 more
core   +4 more sources

T Cell Immunosenescence in Inflammatory Skin Diseases: Pathogenesis and Therapeutic Targets

Aging Cell, Volume 25, Issue 5, May 2026.
Immunosenescent T cells promote inflammatory skin diseases such as psoriasis, atopic dermatitis, rosacea, and seborrheic dermatitis via hyperactive signaling networks and SASP secretion. Consequently, intercepting downstream SASP, inhibiting internal pathways, or utilizing senolytics represents promising therapeutic interventions.
Conghui Liu, Ming Yang, Fugang Xiao, Jinrong Zeng   +3 more
wiley   +1 more source

Transcriptional Regulator CNOT3 Defines an Aggressive Colorectal Cancer Subtype. [PDF]

, 2017
Cancer cells exhibit dramatic alterations of chromatin organization at cis-regulatory elements, but the molecular basis, extent, and impact of these alterations are still being unraveled.
Burgos, E, Cavazza, A, Cejas, P, Feliu, J, Goel, A, Horst, D, Mendiola, M, Moreno, V, Moreno-Rubio, J, Shivdasani, RA, Taing, L, Yandava, CN   +11 more
core   +1 more source