Results 121 to 130 of about 1,031,105 (176)

The yeast Ccr4-Not complex controls ubiquitination of the nascent-associated polypeptide (NAC-EGD) complex

, 2006
In this work, we determine that the Saccharomyces cerevisiae Ccr4-Not complex controls ubiquitination of the conserved ribosome-associated heterodimeric EGD (enhancer of Gal4p DNA binding) complex, which consists of the Egd1p and Egd2p subunits in yeast ...
Paquet, Nicole, Finka, Andrija, Landrieux, Emilie, Feuermann, Marc, Collart, Martine, Panasenko, Olesya   +5 more
core   +1 more source

Bidirectional roles of the Ccr4-Not complex in regulating autophagy before and after nitrogen starvation. [PDF]

Autophagy, 2023
Yin Z, Zhang Z, Lei Y, Klionsky DJ.
europepmc   +1 more source

Composition and function of Ccr4-Not protein complexes

, 2010
Ccr4-Not protein complexes are evolutionarily conserved and have important functions in mRNA regulatory processes. Strict regulation of mRNA’s is important for cells since they form the central connection between the genetic information in the nucleus and active protein production in the cytoplasm.
Lau,N.C., Cancer, Regenerative Medicine and Stem Cells, CMM Sectie Molecular Cancer Research, Timmers, Marc   +4 more
openaire   +1 more source

Multi-functional regulation of 4E-BP gene expression by Ccr4-Not Complex.

, 2015
This figure summarizes the current working hypothesis of how the Ccr4-Not complex regulates the expression of 4E-BP. The balance between transcriptional regulation and mRNA decay exerted by the Ccr4-Not complex determines—at least in part—the total ...
Hirokazu Okada (323221), Anna Straessle (706960), Ralf B. Schittenhelm (706959), Ernst Hafen (2653)   +3 more
core   +1 more source

Regulation of CCR4-NOT complex deadenylase activity and cellular responses by MK2-dependent phosphorylation of CNOT2. [PDF]

RNA Biol, 2022
Suzuki T, Hoshina M, Nishijima S, Hoshina N, Kikuguchi C, Tomohiro T, Fukao A, Fujiwara T, Yamamoto T.   +8 more
europepmc   +1 more source

Biochemical characterisation of the human Ccr4-Not complex: core complex assembly and deadenylation activity [PDF]

, 2018
Targeted degradation of cytoplasmic mRNA is of fundamental importance for regulated gene expression in eukaryotic cells. The shortening and removal of the poly(A) tail (deadenylation) is the initial and often rate-limiting step in this process.
Pavanello, Lorenzo
core  

Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits

, 2000
The yeast CCR4-NOT protein complex is a global regulator of RNA polymerase II transcription. It is comprised of yeast NOT1 to NOT5, yeast CCR4 and additional proteins like yeast CAF1.
Gentz, R, Albert, T K, Lemaire, Marc, Timmers, H T, van Berkum, N L, Collart, Martine   +5 more
core   +1 more source

CAF1-knockout mice are more susceptive to lipopolysaccharide-induced acute lung injury

Journal of Inflammation Research, 2016
Jia-Xin Shi,1 Jia-Shu Li,1 Rong Hu,1 Xiao-Min Li,2 Hong Wang3 1Department of Respiratory Medicine, Lianyungang First People’s Hospital, Affiliated Hospital of Xuzhou Medical University, Affiliated Hospital of the Clinical Medical School of Nanjing ...
Shi JX, Li JS, Hu R, Li XM, Wang H
doaj  

The CCR4-NOT complex suppresses untimely translational activation of maternal mRNAs.

Development, 2023
Soeda S, Oyama M, Kozuka-Hata H, Yamamoto T.   +3 more
europepmc   +1 more source

Haploinsufficiency of Cnot3 Aggravates Acid-Induced Acute Lung Injury Likely Through Transcriptional and Post-Transcriptional Upregulation of Pro-Inflammatory Genes

Journal of Inflammation Research
Tomokazu Yamaguchi,1,2,* Ryo Ozawa,2,3,* Takafumi Minato,2 Midori Hoshizaki,4 Yutaro Kammura,1,5 Kazuma Okawara,1,6 Yousef A Khalil,1 Masafumi Nakamura,6 Ken Yamaura,5 Masayuki Fukuda,3 Yumiko Imai,4 Keiji Kuba1,2 1Department of Pharmacology ...
Yamaguchi T, Ozawa R, Minato T, Hoshizaki M, Kammura Y, Okawara K, Khalil YA, Nakamura M, Yamaura K, Fukuda M, Imai Y, Kuba K   +11 more
doaj