Regulation of Early Lymphocyte Development via mRNA Decay Catalyzed by the CCR4-NOT Complex [PDF]
Development of lymphocytes is precisely regulated by various mechanisms. In addition to transcriptional rates, post-transcriptional regulation of mRNA abundance contributes to differentiation of lymphocytes. mRNA decay is a post-transcriptional mechanism
Yamamoto, Tadashi, Akiyama, Taishin
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A dual, catalytic role for the fission yeast Ccr4-Not complex in gene silencing and heterochromatin spreading. [PDF]
Genetics, 2023 Challal D +5 more
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The CCR4-NOT complex releases PABP from silenced miRNA targets in the absence of deadenylation
, 2013 GW182 family proteins interact with Argonaute proteins and are required for the translational repression, deadenylation and decay of miRNA targets. To elicit these effects, GW182 proteins interact with PABP and the CCR4- NOT deadenylase complex. Although
Zekri, L. +1 more
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CCR4-NOT Complex 2-A Cofactor in Host Cell for Porcine Epidemic Diarrhea Virus Infection. [PDF]
Genes (Basel), 2022 Wang J +16 more
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Biochemical analysis of the nuclease module of the human Ccr4-Not deadenylase complex [PDF]
, 2015 In eukaryotic cells, the shortening and removal of the poly(A) tail (deadenylation) of cytoplasmic mRNA is a key step in mRNA degradation. The Ccr4-Not complex is well-characterised as a major deadenylase enzyme involved in mRNA deadenylation.
Maryati, Maryati
core
Bidirectional roles of the Ccr4-Not complex in regulating autophagy before and after nitrogen starvation. [PDF]
Autophagy, 2023 Yin Z, Zhang Z, Lei Y, Klionsky DJ.
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Biochemical characterisation of the human Ccr4-Not complex: core complex assembly and deadenylation activity [PDF]
, 2018 Targeted degradation of cytoplasmic mRNA is of fundamental importance for regulated gene expression in eukaryotic cells. The shortening and removal of the poly(A) tail (deadenylation) is the initial and often rate-limiting step in this process.
Pavanello, Lorenzo
core
Regulation of CCR4-NOT complex deadenylase activity and cellular responses by MK2-dependent phosphorylation of CNOT2. [PDF]
RNA Biol, 2022 Suzuki T +8 more
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CAF1-knockout mice are more susceptive to lipopolysaccharide-induced acute lung injury
Journal of Inflammation Research, 2016 Jia-Xin Shi,1 Jia-Shu Li,1 Rong Hu,1 Xiao-Min Li,2 Hong Wang3 1Department of Respiratory Medicine, Lianyungang First People’s Hospital, Affiliated Hospital of Xuzhou Medical University, Affiliated Hospital of the Clinical Medical School of Nanjing ...
Shi JX, Li JS, Hu R, Li XM, Wang H
doaj
, 2006 In this work, we determine that the Saccharomyces cerevisiae Ccr4-Not complex controls ubiquitination of the conserved ribosome-associated heterodimeric EGD (enhancer of Gal4p DNA binding) complex, which consists of the Egd1p and Egd2p subunits in yeast ...
Paquet, Nicole +5 more
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