Results 101 to 110 of about 1,031,105 (176)
Cellular Heterogeneity During Arterial Aging
Aging Cell, Volume 25, Issue 7, July 2026.Graphical abstract showing arterial cell subpopulations and their functional changes during aging. Transcriptomic profiling studies across species identify age‐associated endothelial, smooth muscle, fibroblast, and immune cell states characterized by inflammation, extracellular matrix remodeling, phenotypic switching, and cellular senescence ...
He Xu +3 more
wiley +1 more source
, 2015 BACKGROUND: Heterochromatin is essential for chromosome segregation, gene silencing and genome integrity. The fission yeast Schizosaccharomyces pombe contains heterochromatin at centromeres, subtelomeres, and mating type genes, as well as at small ...
Cristina Cotobal +7 more
core +2 more sources
Allergy, Volume 81, Issue 7, Page 2309-2324, July 2026.ABSTRACT Atopic dermatitis and psoriasis are two common cutaneous chronic inflammatory diseases. Although they share similar immunological mechanisms, their clinical implications in the patient are different. This review compares both diseases from different points of view such as genetics, natural history, triggers of disease, and skin barrier defects
Tali Czarnowicki +6 more
wiley +1 more source
An investigation into the structural role of the CCR4-NOT complex in mRNA stability
, 2017 The CCR4-NOT complex is a global regulator of gene expression which controls mRNA levels by removing the poly-(A) tail, a step known as deadenylation and one that constitutes the rate-limiting step in mRNA decay.
Hannah Brazier, Brazier, Hannah
core +2 more sources
Genome Biology, 2019 Background Regulation of the mRNA life cycle is central to gene expression control and determination of cell fate. miRNAs represent a critical mRNA regulatory mechanism, but despite decades of research, their mode of action is still not fully understood.
Ania Wilczynska +14 more
doaj +1 more source
British Journal of Haematology, Volume 209, Issue 1, Page 42-53, July 2026.Summary Sézary syndrome (SS) is an aggressive cutaneous T‐cell lymphoma, characterized by erythroderma, lymphadenopathy and circulating malignant CD4+ T cells. Despite therapeutic advances, SS remains an incurable disease. Early diagnosis is therefore essential for timely therapeutic intervention; however, reliable biomarkers to identify circulating SS
Sara Marchisio +14 more
wiley +1 more source
, 2022 Macroautophagy/autophagy is a highly conserved catabolic process by which cytoplasmic constituents are delivered to the vacuole/lysosome for degradation and recycling.
Zhangyuan Yin (6580478) +3 more
core +1 more source
Ccr4‐Not complex directly regulates transcription elongation
The FASEB Journal, 2010 Many functions have been ascribed to the Ccr4‐Not complex. First described many years ago as a potential regulator of preinitiation complex (PIC) formation, more recently, a large body of evidence indicates it is predominantly cytoplasmic and regulates deadenylation of mRNA and ubiquitylation of substrates in ...
Joseph C Reese +3 more
openaire +1 more source
Functional characterization of the CCR4-NOT transcriptional regulatory complex
, 1999 The CCR4-NOT transcriptional regulatory complex affects expression of a number of genes both positively and negatively. This study demonstrates that the CCR4-NOT complex functionally and physically interacts with TBP and TAFs. Firstly, mutations in CCR4,
Badarinarayana, Vasudeo
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Nature CommunicationsTristetraprolin family of proteins regulate mRNA stability by binding to specific AU-rich elements in transcripts. This binding promotes the shortening of the mRNA poly(A) tail, or deadenylation, initiating mRNA degradation.
Filip Pekovic +6 more
doaj +1 more source