Results 101 to 110 of about 24,702 (192)

Blockade of MCP-1/CCR4 signaling-induced recruitment of activated regulatory cells evokes an antitumor immune response in head and neck squamous cell carcinoma [PDF]

, 2016
published_or_final_versio
Bae, Chan, Clay, Curiel, D'Ambrosio, Dranoff, Fox, Frydecka, Galanaud, Gilboa, Gorczynski, Greenman, Introna, Kim, Koch, Kryczek, Kupper, Lydiatt, Mantovani, Martinez-A, Matsushima, Meloni, Palena, Pisani, Ritter, Rosenberg, Rudensky, Sakaguchi, Sakaguchi, Sakaguchi, Sakaguchi, Silva, Tao, Tartour, Toda, Udono, Vieweg, von Boehmer, Wang, Wen, Wen, Whiteside, Yamaguchi, You, Zou   +44 more
core   +1 more source

scRNA‐Seq reveals anti‐lymphoma immune responses in mogamulizumab‐associated skin eruptions

Journal of the European Academy of Dermatology and Venereology, EarlyView.
CCR4 was expressed in malignant clones and regulatory T cells in untreated CTCL, that were decreased in MAR. Malignant clones in MAR showed a silenced phenotype with decreases in central memory markers SELL and CCR7, and GTP‐binding member GIMAP7 and upregulation of MMP2 inhibitor TIMP2 and tumour suppressor gene RUNX3.
Shannon Meledathu, Agata Kurowski, Malini P. Naidu, Jonas Adalsteinsson, Shane A. Meehan, Natalia Alkon, Lauren R. Port, Sumanth Chennareddy, Emry R. Cohenour, Grace Christensen, Jonah Shulman, Nicholas Gulati, Constanze Jonak, Patrick M. Brunner   +13 more
wiley   +1 more source

A CCR4-NOT Transcription Complex, Subunit 1, CNOT1, Variant Associated with Holoprosencephaly [PDF]

The American Journal of Human Genetics, 2019
Holoprosencephaly is the incomplete separation of the forebrain during embryogenesis. Both genetic and environmental etiologies have been determined for holoprosencephaly; however, a genetic etiology is not found in most cases. In this report, we present two unrelated individuals with semilobar holoprosencephaly who have the identical de novo missense ...
Paul, Kruszka, Seth I, Berger, Karin, Weiss, Joshua L, Everson, Ariel F, Martinez, Sungkook, Hong, Kwame, Anyane-Yeboa, Robert J, Lipinski, Maximilian, Muenke   +8 more
openaire   +2 more sources

The cell cycle regulatory DREAM complex is disrupted by high expression of oncogenic B-Myb. [PDF]

, 2019
Overexpression of the oncogene MYBL2 (B-Myb) is associated with increased cell proliferation and serves as a marker of poor prognosis in cancer. However, the mechanism by which B-Myb alters the cell cycle is not fully understood.
Ananthapadmanabhan, Varsha, Dozmorov, Mikhail, Felthousen, Jessica, Guiley, Keelan Z, Iness, Audra N, Litovchick, Larisa, Rubin, Seth M, Saini, Siddharth, Sesay, Fatmata   +8 more
core  

Molecular Basis for poly(A) RNP Architecture and Recognition by the Pan2-Pan3 Deadenylase

, 2019
The stability of eukaryotic mRNAs is dependent on a ribonucleoprotein (RNP) complex of poly(A)-binding proteins (PABPC1/Pab1) organized on the poly(A) tail.
Conti, E., Reichelt, P., Schuller, J., Schäfer, I., Schüssler, S., Strauss, M., Yamashita, M.   +6 more
core   +1 more source

piRNAs and Aubergine cooperate with Wispy poly(A) polymerase to stabilize mRNAs in the germ plasm [PDF]

, 2017
Piwi-interacting RNAs (piRNAs) and PIWI proteins play a crucial role in germ cells by repressing transposable elements and regulating gene expression. In Drosophila, maternal piRNAs are loaded into the embryo mostly bound to the PIWI protein Aubergine ...
Beilharz, Traude H., Bontonou, Gwénaëlle, Chartier, Aymeric, Dufourt, Jérémy, Harrison, Paul F., Jahan, Camille, Meunier, Anne Cecile, Papin, Catherine, Pierson, Stéphanie, Simonelig, Martine   +9 more
core   +4 more sources

Mapping malignant T‐cell states and immune circuits in Sézary syndrome by single‐cell analysis

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Peripheral blood single‐cell RNA‐seq from leukaemic CTCL defined three malignant T‐cell programmes: MTC CM, MTC Reg and MTC E/EM, each with distinct features and candidate vulnerabilities. For example, inferred immune circuits highlighted actionable IL‐10/JAK–TYK2–STAT3 signalling, KIR–MHC I inhibitory interactions and myeloid/B‐cell inflammatory and ...
Beth A. Childs, Eslam A. Elghonaimy, Praveen Ramakrishnan Geethakumari, Kiran A. Kumar, Joseph F. Merola, Heather W. Goff, Todd A. Aguilera   +6 more
wiley   +1 more source

Identification of novel HIV-1 dependency factors in primary CCR4+CCR6+Th17 cells via a genome-wide transcriptional approach [PDF]

, 2015
Additional file 2: Table S2. The complete list of genes down regulated in Th17 versus Th1 subsets are included and classified based on p-values 
Annie Gosselin, Aurélie Cleret-Buhot, Cécile L. Tremblay, Delphine Planas, Elias K. Haddad, Jean-Philippe Goulet, Jean-Pierre Routy, Mohamed El-Far, Mohammad-Ali Jenabian, Nicolas Chomont, Patricia Monteiro, Petronela Ancuta, Rafick-Pierre Sekaly, Vanessa Sue Wacleche, Yuwei Zhang   +14 more
core   +6 more sources

OsFKBP20‐1b stabilizes OsUPF1 and OsUPF2 to promote the degradation of aberrant mRNAs during dehydration stress

Journal of Integrative Plant Biology, EarlyView.
The rice protein OsFKBP20‐1b protects key RNA‐surveillance factors from breakdown, so they can better eliminate defective messages. This RNA quality‐control boost reduces errors and helps plants survive drought, revealing a link between RNA control and drought tolerance.
Haemyeong Jung, Hyun Ji Park, Seung Hee Jo, Ki‐Hong Jung, Choonkyun Jung, Hye Sun Cho   +5 more
wiley   +1 more source

The role of the E3 ligase Not4 in cotranslational quality control

Frontiers in Genetics, 2014
Cotranslational quality control (QC) is the mechanism by which the cell checks the integrity of newly synthesized proteins and mRNAs. In the event of mistakes these molecules are degraded.
Olesya O Panasenko
doaj   +1 more source