Results 81 to 90 of about 15,618 (178)

Multi-functional regulation of 4E-BP gene expression by the Ccr4-Not complex. [PDF]

PLoS ONE, 2015
The mechanistic target of rapamycin (mTOR) signaling pathway is highly conserved from yeast to humans. It senses various environmental cues to regulate cellular growth and homeostasis.
Hirokazu Okada, Ralf B Schittenhelm, Anna Straessle, Ernst Hafen   +3 more
doaj   +1 more source

Selective Absence of Co‐Inhibitory Receptor‐Expressing CD4+ T Cells in Lungs of Obese House Dust Mite‐Allergic C57BL/6 Mice

Allergy, EarlyView.
Obesity altered the inflammatory phenotype of HDM‐induced allergic airway inflammation in C57BL/6 mice, indicated by changed BAL cell composition. Single‐cell CITE‐Seq identified the lack of a CD4+ T‐cell subcluster characterized by co‐inhibitory receptor expression in obese HDM‐exposed C57BL/6 mice.
Sarah Miethe, Daniel P. Potaczek, Kim Pauck, Andrea Berlin, Bilal Alashkar Alhamwe, Stefanie Hagner, Andrea Nist, Elke Pogge von Strandmann, Thorsten Stiewe, Paul Klemm, Hartmann Raifer, Clemens Thölken, Holger Garn   +12 more
wiley   +1 more source

Transcriptional Regulation by the Ccr4/Not4 Complex

The FASEB Journal, 2011
The CCR4/NOT complex is a global regulator of gene expression that affects expression both positively and negatively. The complex, conserved from yeast to human, is composed of at least nine subunits. The Ccr4 subunit functions in the control of mRNA deadenylation and transcriptional initiation/elongation.
Swati Mehrotra, John Moon, Ales Vancura
openaire   +1 more source

Spatial Transcriptomics Identifies Characteristic Immunological Niches in Atopic Dermatitis

Allergy, EarlyView.
Spatially organized immune niches containing mature migratory dendritic cells (mmDCs) and CD4+ T cells in atopic dermatitis lesions support localized T cell activation and may contribute to disease persistence. Spatial transcriptomics identifies conserved immune niches in atopic dermatitis lesions, characterized by close co‐localization of CD4+ T cells
Lina Gross, Lukas Bäriswyl, Erik Kupschke, Alexandra Wallimann, Hanne Hillen, Philipp Kirchner, Jivko Kamarashev, Martin Wartenberg, Claudio Rhyner, Christoph Schlapbach, Stephan Traidl, Mirjam Schenk   +11 more
wiley   +1 more source

T Cell Microenvironmental Impacts and Therapeutic Opportunities: Application to Human Testicular Germ Cell Tumors

Andrology, EarlyView.
ABSTRACT Testicular germ cell tumors (TGCT) are the leading malignancy in adolescent and young adult males, yet the immunological and cellular mechanisms governing their tumor microenvironment (TME) remain poorly understood. Here, we present a comprehensive review of TGCT pathobiology with a focus on the immune landscape, particularly the role of tumor‐
R Islam, M Figura, J Heyer, S Lieber, M Huber, KL Loveland, HC Schuppe, Daniela Fietz   +7 more
wiley   +1 more source

An investigation into the structural role of the CCR4-NOT complex in mRNA stability [PDF]

, 2017
The CCR4-NOT complex is a global regulator of gene expression which controls mRNA levels by removing the poly-(A) tail, a step known as deadenylation and one that constitutes the rate-limiting step in mRNA decay.
Hannah Brazier, Brazier, Hannah
core   +1 more source

scRNA‐Seq in Gastric Cancer Reveals Macrophage‐Derived C1q as a Diagnostic Marker

Cancer Science, EarlyView.
Single‐cell sequencing of GC analyzed the tumor microenvironment and discovered the C1QA+ TAMs subpopulation with immunosuppressive function. The role of C1q in the prognosis and diagnosis of GC was demonstrated through plasma and tumor tissue from the GC cohort.
Saisai Gong, Yupeng Zhao, Sheng Yang, Tong Liu, Chengyun Li, Yun Zhou, Geyu Liang   +6 more
wiley   +1 more source

The role of the E3 ligase Not4 in cotranslational quality control

Frontiers in Genetics, 2014
Cotranslational quality control (QC) is the mechanism by which the cell checks the integrity of newly synthesized proteins and mRNAs. In the event of mistakes these molecules are degraded.
Olesya O Panasenko
doaj   +1 more source

Primary Cutaneous Gamma‐Delta T‐Cell Lymphoma Complicating Long‐Standing Immunosuppressed Dermatomyositis

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT Primary cutaneous gamma‐delta T‐cell lymphoma (PCGD‐TCL) is a rare cytotoxic lymphoma with key oncogenic drivers in the JAK/STAT pathway. Also primarily involving the subcutaneous adipose tissue, subcutaneous panniculitis‐like T‐cell lymphoma (SPTCL) is more frequently encountered in scenarios of autoimmune disorders.
Bennett Christie‐Nguyen, Youn H. Kim, David F. Fiorentino, Danielle Tartar, Ryanne Brown, Robert A. Novoa, Kerri E. Rieger   +6 more
wiley   +1 more source

Regulation of the Drosophila transcriptome by Pumilio and the CCR4-NOT deadenylase complex

RNA
The sequence-specific RNA-binding protein Pumilio controls Drosophila development; however, the network of mRNAs that it regulates remains incompletely characterized. In this study, we utilize knockdown and knockout approaches coupled with RNA-Seq to measure the impact of Pumilio on the transcriptome of Drosophila cells in culture.
Rebecca J. Haugen, Catherine Barnier, Nathan D. Elrod, Hua Luo, Madeline K. Jensen, Ping Ji, Craig A. Smibert, Howard D. Lipshitz, Eric J. Wagner, P. Lydia Freddolino, Aaron C. Goldstrohm   +10 more
openaire   +2 more sources