Results 61 to 70 of about 24,702 (192)

Control of immediate early gene expression by CPEB4-repressor complex-mediated mRNA degradation

Genome Biology, 2022
Background Cytoplasmic polyadenylation element-binding protein 4 (CPEB4) is known to associate with cytoplasmic polyadenylation elements (CPEs) located in the 3′ untranslated region (UTR) of specific mRNAs and assemble an activator complex promoting the ...
Fabian Poetz, Svetlana Lebedeva, Johanna Schott, Doris Lindner, Uwe Ohler, Georg Stoecklin   +5 more
doaj   +1 more source

Architecture of the ubiquitylation module of the yeast Ccr4-Not complex. [PDF]

Structure, 2015
The Ccr4-Not complex regulates eukaryotic gene expression at multiple levels, including mRNA turnover, translational repression, and transcription. We have studied the ubiquitylation module of the yeast Ccr4-Not complex and addressed how E3 ligase binds cognate E2 and how it is tethered to the complex.
Bhaskar V, Basquin J, Conti E.
europepmc   +4 more sources

The Yeast Ccr4-Not Complex Controls Ubiquitination of the Nascent-associated Polypeptide (NAC-EGD) Complex [PDF]

Journal of Biological Chemistry, 2006
In this work, we determine that the Saccharomyces cerevisiae Ccr4-Not complex controls ubiquitination of the conserved ribosome-associated heterodimeric EGD (enhancer of Gal4p DNA binding) complex, which consists of the Egd1p and Egd2p subunits in yeast and is named NAC (nascent polypeptide-associated complex) in mammals.
Panasenko, Olesya, Landrieux, Emilie, Feuermann, Marc, Finka, Andrija, Paquet, Nicole, Collart, Martine   +5 more
openaire   +3 more sources

Distinct Immunomodulatory Strategies Guide Mesenchymal Stromal/Stem Cell‐Mediated Bone Regeneration

Advanced Science, EarlyView.
Bone regeneration by mesenchymal stem cells is strongly influenced by immune signals. This study shows that priming stem cells with regulatory immune cells or an inflammation‐resolving lipid molecule enhances bone formation through distinct immune pathways.
Salwa Suliman, Carla Alvarez Rivas, Aashish Srivastava, Nora Marek, Kamal Mustafa, Alpdogan Kantarci   +5 more
wiley   +1 more source

Generation of CCR4/CD7 Bispecific CAR‐T Cells Resistant to Fratricide and Exhaustion

Advanced Science, EarlyView.
The applications of CAR T‐cell therapy in T‐cell malignancies face limitations such as fratricide, effector‐cell exhaustion, and antigen‐escape. Herein, we developed fratricide‐ and exhaustion‐resistant CAR‐T cells that targeted CCR4 and CD7 simultaneously, with optional EGFRt safety switch. Additionally, scRNA‐seq unveiled new molecular targets, which
Sile Li, Yuanxin Li, Asif Rashid, Hong Kee Tan, Shing Chan, Man Yan Hui, Wilson Yau Ki Chan, Kee See Lam, Yinping Liu, Wenwei Tu, Wing Leung   +10 more
wiley   +1 more source

The control of elongation by the yeast Ccr4–Not complex [PDF]

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2013
The Ccr4-Not complex is a highly conserved nine-subunit protein complex that has been implicated in virtually all aspects of gene control, including transcription, mRNA decay and quality control, RNA export, translational repression and protein ubiquitylation.
openaire   +2 more sources

Deadenylation of mRNA by the CCR4-NOT complex in Drosophila: molecular and developmental aspects

Frontiers in Genetics, 2014
Controlled shortening of the poly(A) tail of mRNAs is the first step in eukaryotic mRNA decay and can also be used for translational inactivation of mRNAs.
Claudia eTemme, Martine eSimonelig, Elmar eWahle   +2 more
doaj   +1 more source

Tumor‐Induced Splenic Remodeling: Mechanisms of Systemic Immunosuppression and Emerging Therapeutic Opportunities

Advanced Science, EarlyView.
ABSTRACT Despite the transformative impact of cancer immunotherapies such as immune checkpoint blockade, durable clinical responses remain limited. Increasing evidence indicates that antitumor immunity is governed not only by the tumor microenvironment, but also by systemic immune regulation mediated by peripheral immune organs. Among these, the spleen
Yuehua Liu, Xiaoqian Nie, Xiaofei Gao
wiley   +1 more source

An mRNA decapping mutant deficient in P body assembly limits mRNA stabilization in response to osmotic stress [PDF]

, 2017
Yeast is exposed to changing environmental conditions and must adapt its genetic program to provide a homeostatic intracellular environment. An important stress for yeast in the wild is high osmolarity.
A Totaro, A van Hoof, AD Aragon, AP Gasch, AR Albig, C Janke, C Miller, C Molin, CJ Decker, CJ Decker, CW Bourque, D Cao, D Melamed, D Teixeira, D Teixeira, D Zheng, E Garre, F Posas, G Gowrishankar, G Haas, G Haimovich, GR Pilkington, H Donis-Keller, J Coller, J Schindelin, J Warringer, J Yale, JA Arribere, JF Garcia, JF Garcia, JR Buchan, JR Buchan, JS Anderson, JS Bett, L Hatfield, L Romero-Santacreu, M Brengues, M Kshirsagar, M Rep, M Tucker, MAM Reijns, N Alhusaini, N Cougot, N Otsu, R Parker, S Hohmann, S Huch, S Jain, S Tharun, T Grousl, T Nissan, U Sheth, U Sheth, V Balagopal, V Hilgers, V Pelechano, V Pelechano, W Hu, Y Uesono   +58 more
core   +1 more source

Enhanced Intracellular Stability and Translation Efficiency of mRNA Drugs by a 2‐arm mRNA Platform

Advanced Science, EarlyView.
We constructed a 2‐arm mRNA, characterized by a unique topology formed through the dimerization of two mRNA 3’ tails. The 2‐arm mRNA improves 3’ tail stability and resistance to nuclease degradation, resulting in an intracellular half‐life of up to 65 h. This method substantially enhances the translation capacity of mRNA drugs.
Xucong Teng, Jiahao Lin, Qiushuang Zhang, Xiangdong Zhang, Yicong Dai, Jinghong Li   +5 more
wiley   +1 more source