Results 41 to 50 of about 1,031,105 (176)
The Ccr4-Not complex is a key regulator of eukaryotic gene expression. [PDF]
Wiley Interdiscip Rev RNA, 2016 The Ccr4‐Not complex is a multisubunit complex present in all eukaryotes that contributes to regulate gene expression at all steps, from production of messenger RNAs (mRNAs) in the nucleus to their degradation in the cytoplasm. In the nucleus it influences the post‐translational modifications of the chromatin template that has to be remodeled for ...
Collart MA.
europepmc +7 more sources
The Not4 E3 ligase and CCR4 deadenylase play distinct roles in protein quality control. [PDF]
PLoS ONE, 2014 Eukaryotic cells control their proteome by regulating protein production and protein clearance. Protein production is determined to a large extent by mRNA levels, whereas protein degradation depends mostly upon the proteasome.
David Halter +2 more
doaj +1 more source
A conserved CAF40-binding motif in metazoan NOT4 mediates association with the CCR4-NOT complex. [PDF]
Genes Dev, 2019 The multisubunit CCR4-NOT mRNA deadenylase complex plays important roles in the posttranscriptional regulation of gene expression. The NOT4 E3 ubiquitin ligase is a stable component of the CCR4-NOT complex in yeast but does not copurify with the human or
Keskeny C +6 more
europepmc +2 more sources
Ccr4-not regulates RNA polymerase I transcription and couples nutrient signaling to the control of ribosomal RNA biogenesis. [PDF]
PLoS Genetics, 2015 Ribosomal RNA synthesis is controlled by nutrient signaling through the mechanistic target of rapamycin complex 1 (mTORC1) pathway. mTORC1 regulates ribosomal RNA expression by affecting RNA Polymerase I (Pol I)-dependent transcription of the ribosomal ...
R Nicholas Laribee +3 more
doaj +1 more source
The CCR4–NOT Deadenylase Complex Maintains Adipocyte Identity [PDF]
International Journal of Molecular Sciences, 2019 Shortening of poly(A) tails triggers mRNA degradation; hence, mRNA deadenylation regulates many biological events. In the present study, we generated mice lacking the Cnot1 gene, which encodes an essential scaffold subunit of the CCR4–NOT deadenylase complex in adipose tissues (Cnot1-AKO mice) and we examined the role of CCR4–NOT in adipocyte function.
Akinori Takahashi +7 more
openaire +2 more sources
The role of TNRC6 proteins in gene silencing [PDF]
, 2013 Proteins of the GW182 family have recently emerged as key players in miRNAmediated gene silencing. They have been shown to interact with Argonaute proteins, components of the RISC and are assumed to mediate the repression in metazoa. Three paralogues are
Zipprich, Jakob Theophil
core +1 more source
mSphere, 2016 Ccr4, a component of the Ccr4-Not cytoplasmic deadenylase complex, is known to be required for the cell wall integrity (CWI) pathway in the budding yeast Saccharomyces cerevisiae.
Xia Li +6 more
doaj +1 more source
Cell Reports, 2015 The central question in stem cell regulation is how the balance between self-renewal and differentiation is controlled at the molecular level. This study uses germline stem cells (GSCs) in the Drosophila ovary to demonstrate that the Drosophila CCR4 ...
Ziwen Fu +10 more
doaj +1 more source
Interaction between NANOS2 and the CCR4-NOT deadenylation complex is essential for male germ cell development in mouse. [PDF]
PLoS ONE, 2012 Nanos is one of the evolutionarily conserved proteins implicated in germ cell development and we have previously shown that it interacts with the CCR4-NOT deadenylation complex leading to the suppression of specific RNAs. However, the molecular mechanism
Atsushi Suzuki +4 more
doaj +1 more source
Human Ccr4–Not complexes contain variable deadenylase subunits [PDF]
Biochemical Journal, 2009 The Ccr4–Not complex is evolutionarily conserved and important for regulation of mRNA synthesis and decay. The composition of the yeast complex has been well described. Orthologues of the yeast Ccr4–Not components have been identified in human cells including multiple subunits with mRNA deadenylase activity.
Lau, N.C. +6 more
openaire +3 more sources