The Not4 E3 ligase and CCR4 deadenylase play distinct roles in protein quality control. [PDF]
PLoS ONE, 2014 Eukaryotic cells control their proteome by regulating protein production and protein clearance. Protein production is determined to a large extent by mRNA levels, whereas protein degradation depends mostly upon the proteasome.
David Halter +2 more
doaj +1 more source
SPT5 affects the rate of mRNA degradation and physically interacts with CCR4 but does not control mRNA deadenylation [PDF]
, 2011 The CCR4-NOT complex has been shown to have multiple roles in mRNA metabolism, including that of transcriptional elongation, mRNA transport, and nuclear exosome function, but the primary function of CCR4 and CAF1 is in the deadenylation and degradation ...
Chiang, Yueh-Chin +4 more
core +2 more sources
Ccr4-not regulates RNA polymerase I transcription and couples nutrient signaling to the control of ribosomal RNA biogenesis. [PDF]
PLoS Genetics, 2015 Ribosomal RNA synthesis is controlled by nutrient signaling through the mechanistic target of rapamycin complex 1 (mTORC1) pathway. mTORC1 regulates ribosomal RNA expression by affecting RNA Polymerase I (Pol I)-dependent transcription of the ribosomal ...
R Nicholas Laribee +3 more
doaj +1 more source
Identification of ebs1, lsm6 and nup159 as suppressors of spt10 effects at ADH2 in Saccharomyces cerevisiae suggests post-transcriptional defects affect mRNA synthesis [PDF]
, 2012 Suppression of the effects of an spt10 mutation on ADH2 expression is a phenotype shared by a small number of genes whose protein products are either components of the CCR4-NOT complex required for mRNA deadenylation and degradation (CCR4, CAF1, NOT4) or
Anderson, Bradley +2 more
core +3 more sources
Essential functions of the CNOT7/8 catalytic subunits of the CCR4-NOT complex in mRNA regulation and cell viability. [PDF]
RNA Biol, 2020 Mostafa D +10 more
europepmc +2 more sources
Role of Ccr4-Not complex in heterochromatin formation at meiotic genes and subtelomeres in fission yeast. [PDF]
, 2015 BACKGROUND: Heterochromatin is essential for chromosome segregation, gene silencing and genome integrity. The fission yeast Schizosaccharomyces pombe contains heterochromatin at centromeres, subtelomeres, and mating type genes, as well as at small ...
Bähler, Jürg +7 more
core +2 more sources
The structural basis for deadenylation by the CCR4-NOT complex [PDF]
Protein & Cell, 2010 The CCR4-NOT complex is a highly conserved, multifunctional machinery controlling mRNA metabolism. Its components have been implicated in several aspects of mRNA and protein expression, including transcription initiation, elongation, mRNA degradation, ubiquitination, and protein modification.
Mark, Bartlam, Tadashi, Yamamoto
openaire +2 more sources
The mRNA degradation factor Xrn1 regulates transcription elongation in parallel to Ccr4 [PDF]
, 2019 Co-transcriptional imprinting of mRNA by Rpb4 and Rpb7 subunits of RNA polymerase II (RNAPII) and by the Ccr4–Not complex conditions its posttranscriptional fate.
Begley, Victoria Sarah +10 more
core +2 more sources
The enzyme activities of Caf1 and Ccr4 are both required for deadenylation by the human Ccr4-Not nuclease module [PDF]
, 2015 In eukaryotic cells, the shortening and removal of the poly(A) tail (deadenylation) of cytoplasmic mRNA is a key event in regulated mRNA degradation. A major enzyme involved in deadenylation is the Ccr4-Not deadenylase complex, which can be recruited to ...
Aslam +47 more
core +4 more sources
Cell Reports, 2015 The central question in stem cell regulation is how the balance between self-renewal and differentiation is controlled at the molecular level. This study uses germline stem cells (GSCs) in the Drosophila ovary to demonstrate that the Drosophila CCR4 ...
Ziwen Fu +10 more
doaj +1 more source