Results 31 to 40 of about 24,702 (192)

The CCR4-NOT complex suppresses untimely translational activation of maternal mRNAs.

Development, 2023
ABSTRACT Control of mRNA poly(A) tails is essential for regulation of mRNA metabolism, specifically translation efficiency and mRNA stability. Gene expression in maturing oocytes relies largely on post-transcriptional regulation, as genes are transcriptionally silent during oocyte maturation.
Soeda S, Oyama M, Kozuka-Hata H, Yamamoto T.   +3 more
europepmc   +3 more sources

Stoichiometry and Change of the mRNA Closed-Loop Factors as Translating Ribosomes Transit from Initiation to Elongation [PDF]

, 2016
Protein synthesis is a highly efficient process and is under exacting control. Yet, the actual abundance of translation factors present in translating complexes and how these abundances change during the transit of a ribosome across an mRNA remains ...
Chiang, Yueh-Chin, Denis, Clyde L., Hasek, Jiri, Laue, Thomas M., Toomey, Shaun, Wang, Xin, Xi, Wen   +6 more
core   +15 more sources

Specific tRNAs promote mRNA decay by recruiting the CCR4-NOT complex to translating ribosomes. [PDF]

Science
Zhu X, Cruz VE, Zhang H, Erzberger JP, Mendell JT.   +4 more
europepmc   +2 more sources

Human Ccr4–Not complexes contain variable deadenylase subunits [PDF]

Biochemical Journal, 2009
The Ccr4–Not complex is evolutionarily conserved and important for regulation of mRNA synthesis and decay. The composition of the yeast complex has been well described. Orthologues of the yeast Ccr4–Not components have been identified in human cells including multiple subunits with mRNA deadenylase activity.
Lau, N.C., Kolkman, A., van Schaik, F.M.A., Mulder, K.W., Pijnappel, W.W.M., Heck, A.J.R., Timmers, H.T.M.   +6 more
openaire   +3 more sources

The CCR4-NOT complex physically and functionally interacts with TRAMP and the nuclear exosome. [PDF]

PLoS ONE, 2009
BACKGROUND:Ccr4-Not is a highly conserved multi-protein complex consisting in yeast of 9 subunits, including Not5 and the major yeast deadenylase Ccr4.
Nowel Azzouz, Olesya O Panasenko, Geoffroy Colau, Martine A Collart   +3 more
doaj   +1 more source

The CCR4–NOT Deadenylase Complex Maintains Adipocyte Identity [PDF]

International Journal of Molecular Sciences, 2019
Shortening of poly(A) tails triggers mRNA degradation; hence, mRNA deadenylation regulates many biological events. In the present study, we generated mice lacking the Cnot1 gene, which encodes an essential scaffold subunit of the CCR4–NOT deadenylase complex in adipose tissues (Cnot1-AKO mice) and we examined the role of CCR4–NOT in adipocyte function.
Akinori Takahashi, Shohei Takaoka, Shungo Kobori, Tomokazu Yamaguchi, Sara Ferwati, Keiji Kuba, Tadashi Yamamoto, Toru Suzuki   +7 more
openaire   +2 more sources

The Ccr4-Not Complex Regulates Skn7 through Srb10 Kinase [PDF]

Eukaryotic Cell, 2007
ABSTRACT The Ccr4-Not complex is a multifunctional regulatory platform composed of nine subunits that controls diverse cellular events including mRNA degradation, protein ubiquitination, and transcription. In this study, we identified the yeast Saccharomyces cerevisiae osmotic and oxidative stress ...
Lenssen, Eve, Azzouz, Nowel, Michel, Agnès, Landrieux, Emilie, Collart, Martine   +4 more
openaire   +3 more sources

RNF219 regulates CCR4-NOT function in mRNA translation and deadenylation

Scientific Reports, 2022
Post-transcriptional regulatory mechanisms play a role in many biological contexts through the control of mRNA degradation, translation and localization.
Aude Guénolé, Fabien Velilla, Aymeric Chartier, April Rich, Anne-Ruxandra Carvunis, Claude Sardet, Martine Simonelig, Bijan Sobhian   +7 more
doaj   +1 more source

The multifunctional Ccr4–Not complex directly promotes transcription elongation [PDF]

Genes & Development, 2011
The Ccr4–Not complex has been implicated in the control of multiple steps of mRNA metabolism; however, its functions in transcription remain ambiguous. The discovery that Ccr4/Pop2 is the major cytoplasmic mRNA deadenylase and the detection of Not proteins within mRNA processing bodies have raised questions about the roles of the Ccr4–Not complex in ...
Jennifer A, Kruk, Arnob, Dutta, Jianhua, Fu, David S, Gilmour, Joseph C, Reese   +4 more
openaire   +2 more sources

The Ccr4-Not Complex: Architecture and Structural Insights

Subcellular Biochemistry, 2017
The Ccr4-Not complex is an essential multi-subunit protein complex that plays a fundamental role in eukaryotic mRNA metabolism and has a multitude of different roles that impact eukaryotic gene expression . It has a conserved core of three Not proteins, the Ccr4 protein, and two Ccr4 associated factors, Caf1 and Caf40.
Collart, Martine, Panasenko, Olesya
openaire   +4 more sources