Translation efficiency driven by CNOT3 subunit of the CCR4-NOT complex promotes leukemogenesis [PDF]
Nature CommunicationsProtein synthesis is frequently deregulated during tumorigenesis. However, the precise contexts of selective translational control and the regulators of such mechanisms in cancer is poorly understood.
Maryam Ghashghaei +23 more
doaj +2 more sources
Reconstitution of Targeted Deadenylation by the Ccr4-Not Complex and the YTH Domain Protein Mmi1. [PDF]
Cell Rep, 2016 SummaryCcr4-Not is a conserved protein complex that shortens the 3′ poly(A) tails of eukaryotic mRNAs to regulate transcript stability and translation into proteins. RNA-binding proteins are thought to facilitate recruitment of Ccr4-Not to certain mRNAs,
Stowell JAW +5 more
europepmc +3 more sources
Ccr4-Not complex reduces transcription efficiency in heterochromatin. [PDF]
Nucleic Acids Res, 2022 Abstract Heterochromatic silencing is thought to occur through a combination of transcriptional silencing and RNA degradation, but the relative contribution of each pathway is not known. In this study, we analyzed RNA Polymerase II (RNA Pol II) occupancy and levels of nascent and steady-state RNA in different mutants of ...
Monteagudo-Mesas P +5 more
europepmc +4 more sources
The essential function of Not1 lies within the Ccr4-Not complex
Journal of Molecular Biology, 2000 The five Saccharomyces cerevisiae Not proteins are associated with the Ccr4 and Caf1 proteins in 1.2 MDa and 2 MDa complexes. The Not proteins have been proposed to repress transcription of promoters that do not contain a canonical TATA sequence, while ...
Tu, Chi +4 more
core +6 more sources
Specific roles for the Ccr4-Not complex subunits in expression of the genome [PDF]
RNA, 2009 In this work we used micro-array experiments to determine the role of each nonessential subunit of the conserved Ccr4-Not complex in the control of gene expression in the yeast Saccharomyces cerevisiae.
Azzouz, Nowel +5 more
core +4 more sources
RNF219 attenuates global mRNA decay through inhibition of CCR4-NOT complex-mediated deadenylation. [PDF]
Nat Commun, 2021 The CCR4-NOT complex acts as a central player in the control of mRNA turnover and mediates accelerated mRNA degradation upon HDAC inhibition. Here, we explored acetylation-induced changes in the composition of the CCR4-NOT complex by purification of the ...
Poetz F +10 more
europepmc +2 more sources
Essential functions of the CNOT7/8 catalytic subunits of the CCR4-NOT complex in mRNA regulation and cell viability. [PDF]
RNA Biol, 2020 Mostafa D +10 more
europepmc +2 more sources
The structural basis for deadenylation by the CCR4-NOT complex [PDF]
Protein & Cell, 2010 The CCR4-NOT complex is a highly conserved, multifunctional machinery controlling mRNA metabolism. Its components have been implicated in several aspects of mRNA and protein expression, including transcription initiation, elongation, mRNA degradation, ubiquitination, and protein modification.
Mark, Bartlam, Tadashi, Yamamoto
openaire +2 more sources
The Ccr4-Not complex monitors the translating ribosome for codon optimality. [PDF]
Science, 2020 Coupling translation and mRNA decay Gene expression requires messenger RNAs (mRNAs)—DNA-derived blueprints of genes—to be translated by protein-producing ribosomes. The levels of mRNAs are tightly regulated, in part by controlling their half-lives.
Buschauer R +16 more
europepmc +4 more sources
RNF219 regulates CCR4-NOT function in mRNA translation and deadenylation
Scientific Reports, 2022 Post-transcriptional regulatory mechanisms play a role in many biological contexts through the control of mRNA degradation, translation and localization.
Aude Guénolé +7 more
doaj +1 more source