The essential function of not1 lies within the Ccr4-not complex
Journal of Molecular Biology, 2000 The five Saccharomyces cerevisiae Not proteins are associated with the Ccr4 and Caf1 proteins in 1.2 MDa and 2 MDa complexes. The Not proteins have been proposed to repress transcription of promoters that do not contain a canonical TATA sequence, while the Ccr4 and Caf1 proteins are required for non-fermentative gene expression.
Maillet, Laurent Jean Marie +4 more
core +6 more sources
The CCR4-NOT complex is a tumor suppressor in Drosophila melanogaster eye cancer models [PDF]
Journal of Hematology & Oncology, 2018 Background The CNOT3 protein is a subunit of the CCR4-NOT complex, which is involved in mRNA degradation. We recently identified CNOT3 loss-of-function mutations in patients with T-cell acute lymphoblastic leukemia (T-ALL). Methods Here, we use different
Carmen Vicente +9 more
doaj +2 more sources
The CCR4-NOT complex contributes to repression of Major Histocompatibility Complex class II transcription [PDF]
Scientific Reports, 2017 The multi-subunit CCR4 (carbon catabolite repressor 4)-NOT (Negative on TATA) complex serves as a central coordinator of all different steps of eukaryotic gene expression.
Alfonso Rodríguez-Gil +9 more
doaj +2 more sources
Translation efficiency driven by CNOT3 subunit of the CCR4-NOT complex promotes leukemogenesis [PDF]
Nature CommunicationsProtein synthesis is frequently deregulated during tumorigenesis. However, the precise contexts of selective translational control and the regulators of such mechanisms in cancer is poorly understood.
Maryam Ghashghaei +23 more
doaj +2 more sources
Ccr4-Not complex reduces transcription efficiency in heterochromatin. [PDF]
Nucleic Acids Res, 2022 Abstract Heterochromatic silencing is thought to occur through a combination of transcriptional silencing and RNA degradation, but the relative contribution of each pathway is not known. In this study, we analyzed RNA Polymerase II (RNA Pol II) occupancy and levels of nascent and steady-state RNA in different mutants of ...
Monteagudo-Mesas P +5 more
europepmc +4 more sources
Specific roles for the Ccr4-Not complex subunits in expression of the genome [PDF]
RNA, 2009 In this work we used micro-array experiments to determine the role of each nonessential subunit of the conserved Ccr4-Not complex in the control of gene expression in the yeastSaccharomyces cerevisiae. The study was performed with cells growing exponentially in high glucose and with cells grown to glucose depletion.
Azzouz, Nowel +5 more
openaire +4 more sources
RNF219 attenuates global mRNA decay through inhibition of CCR4-NOT complex-mediated deadenylation. [PDF]
Nat Commun, 2021 The CCR4-NOT complex acts as a central player in the control of mRNA turnover and mediates accelerated mRNA degradation upon HDAC inhibition. Here, we explored acetylation-induced changes in the composition of the CCR4-NOT complex by purification of the ...
Poetz F +10 more
europepmc +3 more sources
Essential functions of the CNOT7/8 catalytic subunits of the CCR4-NOT complex in mRNA regulation and cell viability [PDF]
RNA Biology, 2020 Dina Mostafa +2 more
exaly +2 more sources
The structural basis for deadenylation by the CCR4-NOT complex [PDF]
Protein & Cell, 2010 The CCR4-NOT complex is a highly conserved, multifunctional machinery controlling mRNA metabolism. Its components have been implicated in several aspects of mRNA and protein expression, including transcription initiation, elongation, mRNA degradation, ubiquitination, and protein modification.
Mark, Bartlam, Tadashi, Yamamoto
openaire +2 more sources
The Ccr4-Not complex monitors the translating ribosome for codon optimality. [PDF]
Science, 2020 Coupling translation and mRNA decay Gene expression requires messenger RNAs (mRNAs)—DNA-derived blueprints of genes—to be translated by protein-producing ribosomes. The levels of mRNAs are tightly regulated, in part by controlling their half-lives.
Buschauer R +16 more
europepmc +4 more sources