Results 11 to 20 of about 1,031,105 (176)
The architecture of the Schizosaccharomyces pombe CCR4-NOT complex [PDF]
Nature Communications, 2016 CCR4-NOT is a protein complex involved in a variety of important genetic processes. Here, the authors report the mid-resolution structure of this complex, and model the positions and contacts between the subunits, providing structural support for the ...
Marta Ukleja +7 more
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The Ccr4-Not complex interacts with the mRNA export machinery. [PDF]
PLoS ONE, 2011 The Ccr4-Not complex is a key eukaryotic regulator of gene transcription and cytoplasmic mRNA degradation. Whether this complex also affects aspects of post-transcriptional gene regulation, such as mRNA export, remains largely unexplored.
Shana C Kerr +6 more
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The CCR4-NOT complex physically and functionally interacts with TRAMP and the nuclear exosome. [PDF]
PLoS ONE, 2009 BACKGROUND:Ccr4-Not is a highly conserved multi-protein complex consisting in yeast of 9 subunits, including Not5 and the major yeast deadenylase Ccr4.
Nowel Azzouz +3 more
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Insights into the structure and architecture of the CCR4-NOT complex [PDF]
Frontiers in Genetics, 2014 The CCR4-NOT complex is a highly conserved, multifunctional machinery with a general role in controlling mRNA metabolism. It has been implicated in a number of different aspects of mRNA and protein expression, including mRNA degradation, transcription ...
Kun eXu +4 more
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Heterogeneity and complexity within the nuclease module of the Ccr4-Not complex [PDF]
Frontiers in Genetics, 2013 The shortening of the poly(A) tail of cytoplasmic mRNA (deadenylation) is a pivotal step in the regulation of gene expression in eukaryotic cells. Deadenylation impacts on both regulated mRNA decay as well as the rate of mRNA translation.
Gerlof Sebastiaan Winkler +1 more
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Architecture of the Nuclease Module of the Yeast Ccr4-Not Complex: the Not1-Caf1-Ccr4 Interaction [PDF]
Molecular Cell, 2012 Shortening eukaryotic poly(A) tails represses mRNA translation and induces mRNA turnover. The major cytoplasmic deadenylase, the Ccr4-Not complex, is a conserved multisubunit assembly. Ccr4-Not is organized around Not1, a large scaffold protein that recruits two 3'-5' exoribonucleases, Caf1 and Ccr4.
Jérôme Basquin +5 more
openaire +4 more sources
Gene, 2012 The Ccr4-Not complex is a unique, essential and conserved multi-subunit complex that acts at the level of many different cellular functions to regulate gene expression. Two enzymatic activities, namely ubiquitination and deadenylation, are provided by different subunits of the complex.
Collart, Martine, Panasenko, Olesya
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Multifunctional roles of the mammalian CCR4-NOT complex in physiological phenomena
Frontiers in Genetics, 2014 The CCR4-NOT complex serves as one of the major deadenylases of eukaryotes. Although it was originally identified and characterized in yeast, recent studies have revealed that the CCR4-NOT complex also exerts important functions in mammals, including ...
Yo-Taro eShirai +5 more
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The Ccr4-Not Complex: Architecture and Structural Insights
Subcellular Biochemistry, 2017 The Ccr4-Not complex is an essential multi-subunit protein complex that plays a fundamental role in eukaryotic mRNA metabolism and has a multitude of different roles that impact eukaryotic gene expression . It has a conserved core of three Not proteins, the Ccr4 protein, and two Ccr4 associated factors, Caf1 and Caf40.
Collart, Martine, Panasenko, Olesya
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Novel roles of the multifunctional CCR4-NOT complex in post-transcriptional regulation
Frontiers in Genetics, 2014 The CCR4-NOT complex is highly conserved gene silencer, and more general functions of the complex have been elucidated at post-transcriptional levels. Specific regulatory proteins, including miRNA-induced silencing complex and its associate protein, bind
Toshifumi eInada, Shiho eMakino
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