The Ccr4-not complex regulates Skn7 through Srb10 kinase [PDF]
Eukaryotic Cell, 2007 The Ccr4-Not complex is a multifunctional regulatory platform composed of nine subunits that controls diverse cellular events including mRNA degradation, protein ubiquitination, and transcription.
Lenssen, Eve +4 more
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The CCR4 and CAF1 proteins of the CCR4-NOT complex are physically and functionally separated from NOT2, NOT4, and NOT5 [PDF]
Molecular and Cellular Biology, 1999 The CCR4-NOT complex (1 mDa in size), consisting of the proteins CCR4, CAF1, and NOT1 to NOT5, regulates gene expression both positively and negatively and is distinct from other large transcriptional complexes in Saccharomyces cerevisiae such as SNF/SWI,
Chiang, Yueh-Chin +5 more
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The multifunctional Ccr4–Not complex directly promotes transcription elongation [PDF]
Genes & Development, 2011 The Ccr4–Not complex has been implicated in the control of multiple steps of mRNA metabolism; however, its functions in transcription remain ambiguous.
Arnob Dutta +4 more
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Differential regulation of mRNA fate by the human Ccr4-Not complex is driven by coding sequence composition and mRNA localization [PDF]
Genome Biology, 2021 Background Regulation of protein output at the level of translation allows for a rapid adaptation to dynamic changes to the cell’s requirements. This precise control of gene expression is achieved by complex and interlinked biochemical processes that ...
Sarah L. Gillen +5 more
doaj +2 more sources
Structural studies of the complex CCR4-NOT
, 2015 Le recyclage des ARN débute par un étape de déadenylation ou la queue poly (A) est enzymatiquement clivée. La deadenylation est l’étape limitante dans le processus de dégradation des ARN.
Basquin, Jérôme
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The Not5 subunit of the ccr4-not complex connects transcription and translation. [PDF]
PLoS Genetics, 2014 Recent studies have suggested that a sub-complex of RNA polymerase II composed of Rpb4 and Rpb7 couples the nuclear and cytoplasmic stages of gene expression by associating with newly made mRNAs in the nucleus, and contributing to their translation and ...
Zoltan Villanyi +8 more
doaj +9 more sources
Subunits of the Drosophila CCR4-NOT complex and their roles in mRNA deadenylation. [PDF]
RNA, 2010 The CCR4-NOT complex is the main enzyme catalyzing the deadenylation of mRNA. We have investigated the composition of this complex in Drosophila melanogaster by immunoprecipitation with a monoclonal antibody directed against NOT1. The CCR4, CAF1 (=POP2),
Sinz, A. +8 more
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The CCR4-NOT complex is implicated in the viability of aneuploid yeasts.
PLoS Genetics, 2012 To identify the genes required to sustain aneuploid viability, we screened a deletion library of non-essential genes in the fission yeast Schizosaccharomyces pombe, in which most types of aneuploidy are eventually lethal to the cell.
Yoshie Tange +12 more
doaj +3 more sources
The CCR4-NOT complex contributes to repression of Major Histocompatibility Complex class II transcription [PDF]
Scientific Reports, 2017 The multi-subunit CCR4 (carbon catabolite repressor 4)-NOT (Negative on TATA) complex serves as a central coordinator of all different steps of eukaryotic gene expression.
Alfonso Rodríguez-Gil +9 more
doaj +2 more sources
The CCR4-NOT complex is a tumor suppressor in Drosophila melanogaster eye cancer models [PDF]
Journal of Hematology & Oncology, 2018 Background The CNOT3 protein is a subunit of the CCR4-NOT complex, which is involved in mRNA degradation. We recently identified CNOT3 loss-of-function mutations in patients with T-cell acute lymphoblastic leukemia (T-ALL). Methods Here, we use different
Carmen Vicente +9 more
doaj +2 more sources