Results 71 to 80 of about 1,031,105 (176)

Stable and Functional Regulatory T Cells for Adoptive Cell Therapy

Barrier Immunity, EarlyView.
Deprivation of CD28 signaling combined with CDK8/19 inhibition induces stable iTregs with demethylation of Treg‐DRs. Re‐stimulation of these iTregs with additional agents further enhances their suppressive function. The generated S/F‐iTregs suppress inflammation in vivo, and subset of the suppressed Tconvs is converted into de novo pTregs, contributing
Norihisa Mikami
wiley   +1 more source

The cellular roles of Ccr4-NOT in model and pathogenic fungi – implications for fungal virulence

Frontiers in Genetics, 2013
The fungal Ccr4-NOT complex has been implicated in orchestrating gene expression networks that impact on pathways key for virulence in pathogenic species.
John C. Panepinto, Eva eHeinz, Ana eTraven   +2 more
doaj   +1 more source

Radiotherapy and Immunotherapy In Hepatocellular Carcinoma: Priming the Tumor Immune Microenvironment From Bench To Bedside

Precision Radiation Oncology, EarlyView.
The dual immunomodulatory network of radiotherapy in hepatocellular carcinoma. Radiotherapy initiates its effects by inducing immunogenic cell death and DNA double‐strand breaks. Immune Activation: Cytosolic DNA from damaged cells activates the cGAS‐STING pathway, triggering IRF3/NF‐κB‐mediated type I interferon production. This enhances dendritic cell
Zhigang Fu, Yang Zhang, Zuomin Wang, Zongjuan Li, Shisuo Du   +4 more
wiley   +1 more source

Cellular Mechanism and Key Insights in Allergen Immunotherapy for Allergic Rhinitis

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Allergic rhinitis (AR) arises from immune responses mediated by immunoglobulin E (IgE) to inhaled allergens, representing one of the most prevalent chronic conditions worldwide. Although AR may not be a serious ailment, it holds clinical relevance as it underpins numerous complications, serves as a major risk factor for suboptimal asthma ...
Zhe Wang, Teng‐Fei Li, Tian‐Yu Wang, Huan‐Hai Liu   +3 more
wiley   +1 more source

Transcriptional Regulation by the Ccr4/Not4 Complex

The FASEB Journal, 2011
The CCR4/NOT complex is a global regulator of gene expression that affects expression both positively and negatively. The complex, conserved from yeast to human, is composed of at least nine subunits. The Ccr4 subunit functions in the control of mRNA deadenylation and transcriptional initiation/elongation.
Swati Mehrotra, John Moon, Ales Vancura
openaire   +1 more source

The CCR4-NOT complex mediates deadenylation and degradation of stem cell mRNAs and promotes planarian stem cell differentiation. [PDF]

PLoS Genetics, 2013
Post-transcriptional regulatory mechanisms are of fundamental importance to form robust genetic networks, but their roles in stem cell pluripotency remain poorly understood.
Jordi Solana, Chiara Gamberi, Yuliana Mihaylova, Stefanie Grosswendt, Chen Chen, Paul Lasko, Nikolaus Rajewsky, A Aziz Aboobaker   +7 more
doaj   +1 more source

Update on Non‐Biological and RNA‐Based Therapeutics in Chronic Inflammatory Diseases: Precision Medicine Through Small Molecules: An EAACI Position Paper

Allergy, EarlyView.
ABSTRACT In the last decades, critical advancements in research technology and knowledge on disease mechanisms steered therapeutic approaches for chronic inflammatory diseases towards unprecedented target specificity. For allergic and chronic lung diseases, biologic drugs pioneered this goal, acquiring on the way—through the clinical use of monoclonal ...
F. Roth‐Walter, I. M. Adcock, C. Benito‐Villalvilla, R. Bianchini, L. Bjermer, G. Caramori, L. Cari, K. F. Chung, Z. Diamant, I. Eguiluz‐Gracia, E. F. Knol, M. Jesenak, F. Levi‐Schaffer, G. Nocentini, L. O'Mahony, O. Palomares, F. Redegeld, M. Sokolowska, B. Van Esch, M. Zurlo, C. Stellato   +20 more
wiley   +1 more source

The E3 ubiquitin ligase, RNF219, suppresses CNOT6L expression to exhibit antiproliferative activity

FEBS Open Bio
Despite the increasing evidence of the role of CCR4‐NOT complex in posttranscriptional gene regulation, relatively little is known about its mode of action. In a search for novel CCR4‐NOT interacting partners, we carried out mass spectrometry analysis of
Shou Soeda, Melissa Montrose, Akinori Takahashi, Risa Ishida, Sandrine Burriel, Nao Ohmine, Tohru Natsume, Shungo Adachi, Minsoo Kim, Tadashi Yamamoto   +9 more
doaj   +1 more source

Mutations in the NOT Genes or in the Translation Machinery Similarly Display Increased Resistance to Histidine Starvation

Frontiers in Genetics, 2017
The NOT genes encode subunits of the conserved Ccr4-Not complex, a global regulator of gene expression, and in particular of mRNA metabolism. They were originally identified in a selection for increased resistance to histidine starvation in the yeast S ...
Martine A. Collart, Sari Kassem, Zoltan Villanyi   +2 more
doaj   +1 more source

Multi-functional regulation of 4E-BP gene expression by the Ccr4-Not complex. [PDF]

PLoS ONE, 2015
The mechanistic target of rapamycin (mTOR) signaling pathway is highly conserved from yeast to humans. It senses various environmental cues to regulate cellular growth and homeostasis.
Hirokazu Okada, Ralf B Schittenhelm, Anna Straessle, Ernst Hafen   +3 more
doaj   +1 more source