Results 91 to 100 of about 24,702 (192)

The CCR4-NOT complex mediates deadenylation and degradation of stem cell mRNAs and promotes planarian stem cell differentiation. [PDF]

PLoS Genetics, 2013
Post-transcriptional regulatory mechanisms are of fundamental importance to form robust genetic networks, but their roles in stem cell pluripotency remain poorly understood.
Jordi Solana, Chiara Gamberi, Yuliana Mihaylova, Stefanie Grosswendt, Chen Chen, Paul Lasko, Nikolaus Rajewsky, A Aziz Aboobaker   +7 more
doaj   +1 more source

The role of the immune system in brain metastasis [PDF]

, 2019
Metastatic brain tumors are the most common brain tumors in adults. With numerous successful advancements in systemic treatment of most common cancer types, brain metastasis is becoming increasingly important in the overall prognosis of cancer patients ...
Dey, Mahua, Leibold, Adam T., Monaco, Gina N.   +2 more
core  

Influenza and memory T cells : how to awake the force [PDF]

, 2016
Annual influenza vaccination is an effective way to prevent human influenza. Current vaccines are mainly focused on eliciting a strain-matched humoral immune response, requiring yearly updates, and do not provide protection for all vaccinated individuals.
Glezen, Hartshorn, Hufford, Jin, Jordan, Luo, Mosmann, Razvi, Topham, Topham, Topham, Von Andrian, Wijburg   +12 more
core   +3 more sources

High frequency of CD95+/CD45RA− regulatory T cells defines an immunosuppressive profile associated with MDS progression

British Journal of Haematology, EarlyView.
Summary Dynamic interactions between mutated haematopoietic cells and immune cells are key drivers of myelodysplastic neoplasms (MDS) initiation and progression. Regulatory T cells (Tregs) are central mediators of immunosuppression in MDS. We thus aimed to characterize Treg subpopulations in the bone marrow (BM) of MDS patients and to explore their ...
Romain Vazquez, Nicolas Deredec, Ismael Boussaid, Pierre Boncoeur, Camille Knosp, Amandine Houvert, Loria Zalmai, Chloe Friedrich, Carole Almire, Charles Dussiau, Lise Willems, Rudy Birsen, Justine Decroocq, Didier Bouscary, Olivier Kosmider, Shahram Kordasti, Michaela Fontenay, Yannick Simoni, Nicolas Chapuis   +18 more
wiley   +1 more source

Interaction of antiproliferative protein Tob with the CCR4‐NOT deadenylase complex

Cancer Science, 2008
Tob protein, when overexpressed, suppresses growth of NIH3T3 cells, presumably by regulating expression of various growth‐related genes. However, the molecular mechanisms underlying Tob‐mediated regulation of gene expression have been obscure. To address this issue we established stable Tob‐expressing cell lines and used a proteomics approach to ...
Takashi, Miyasaka, Masahiro, Morita, Kentaro, Ito, Toru, Suzuki, Hiroyuki, Fukuda, Shizu, Takeda, Jun-Ichiro, Inoue, Kentaro, Semba, Tadashi, Yamamoto   +8 more
openaire   +2 more sources

Multi-functional regulation of 4E-BP gene expression by the Ccr4-Not complex. [PDF]

PLoS ONE, 2015
The mechanistic target of rapamycin (mTOR) signaling pathway is highly conserved from yeast to humans. It senses various environmental cues to regulate cellular growth and homeostasis.
Hirokazu Okada, Ralf B Schittenhelm, Anna Straessle, Ernst Hafen   +3 more
doaj   +1 more source

Reconstitution of Targeted Deadenylation by the Ccr4-Not Complex and the YTH Domain Protein Mmi1.

Cell Rep, 2016
Stowell JAW, Webster MW, Kögel A, Wolf J, Shelley KL, Passmore LA.   +5 more
europepmc   +2 more sources

AMSC‐sEVs Ameliorated Crohn's Disease by Inhibiting Macrophage‐Myofibroblast Transition Through the Delivery of MFGE8

Cell Proliferation, EarlyView.
Our study demonstrated that TGF‐β1 activated MAPK signalling pathway and promoted the MMT and secretion of CCL17 under CD‐associated intestinal inflammatory conditions. AMSC‐sEVs can deliver MFGE8, which inhibits MMT and CCL17‐mediated Treg recruitment by suppressing the MAPK signalling pathway, thereby alleviating intestinal fibrosis.
Minghao Xie, Qiang Liu, Zhizhong Xiong, Jian Li, Ruiri Jin, Lei Lian, Zhengrong Li   +6 more
wiley   +1 more source

The E3 ubiquitin ligase, RNF219, suppresses CNOT6L expression to exhibit antiproliferative activity

FEBS Open Bio
Despite the increasing evidence of the role of CCR4‐NOT complex in posttranscriptional gene regulation, relatively little is known about its mode of action. In a search for novel CCR4‐NOT interacting partners, we carried out mass spectrometry analysis of
Shou Soeda, Melissa Montrose, Akinori Takahashi, Risa Ishida, Sandrine Burriel, Nao Ohmine, Tohru Natsume, Shungo Adachi, Minsoo Kim, Tadashi Yamamoto   +9 more
doaj   +1 more source

Mutations in the NOT Genes or in the Translation Machinery Similarly Display Increased Resistance to Histidine Starvation

Frontiers in Genetics, 2017
The NOT genes encode subunits of the conserved Ccr4-Not complex, a global regulator of gene expression, and in particular of mRNA metabolism. They were originally identified in a selection for increased resistance to histidine starvation in the yeast S ...
Martine A. Collart, Sari Kassem, Zoltan Villanyi   +2 more
doaj   +1 more source