Results 91 to 100 of about 15,618 (178)
Cutaneous lymphomas – an update
Histopathology, EarlyView.Primary cutaneous lymphomas and lymphoproliferative disorders are defined by integrated clinical, histopathological, immunophenotypic and genetic features as diagnostic criteria also in the 5th edition of the WHO classification of haematolymphoid tumors.
Werner Kempf, Christina Mitteldorf
wiley +1 more source
Human DDX6 regulates translation and decay of inefficiently translated mRNAs
eLifeRecent findings indicate that the translation elongation rate influences mRNA stability. One of the factors that has been implicated in this link between mRNA decay and translation speed is the yeast DEAD-box helicase Dhh1p.
Ramona Weber, Chung-Te Chang
doaj +1 more source
Immunology, EarlyView.This systematic review establishes disease‐specific dysregulations of human innate lymphoid cells (ILCs), demonstrating that an ILC1/ILC3 imbalance compromises mucosal barriers in inflammatory bowel disease, while activated ILC2s drive allergic airway inflammation.
Luan F. Lückmann +7 more
wiley +1 more source
Building on the Ccr4‐Not architecture
, 2016 In a recent issue of Nature Communications Ukleja and co-workers reported a cryo-EM 3D reconstruction of the Ccr4-Not complex from Schizosaccharomyces pombe with an immunolocalization of the different subunits.
Zoltan Villanyi +3 more
core +1 more source
FEBS Open Bio, 2019 In eukaryotic cells, cytoplasmic mRNA is characterised by a 3′ poly(A) tail. The shortening and removal of poly(A) tails (deadenylation) by the Ccr4‐Not nuclease complex leads to reduced translational efficiency and RNA degradation.
Blessing Airhihen +4 more
doaj +1 more source
Etiology, pathogenesis and treatment of peri‐implantitis: A European perspective
Periodontology 2000, EarlyView.Abstract Peri‐implantitis is a plaque‐associated pathological condition occurring in tissues around dental implants. It is characterized by inflammation in the peri‐implant mucosa and progressive loss of supporting bone. Over the last 30 years, peri‐implantitis has become a major disease burden in dentistry.
Tord Berglundh +3 more
wiley +1 more source
Implication of Ccr4-Not complex function in mRNA quality control in Saccharomyces cerevisiae
, 2011 Production of messenger ribonucleoprotein particles (mRNPs) is subjected to quality control (QC). In Saccharomyces cerevisiae, the RNA exosome and its cofactors are part of the nuclear QC machinery that removes, or stalls, aberrant molecules, thereby ...
Jannie Assenholt +5 more
core +1 more source
Translating gut microbiome research into therapies for type 1 diabetes
Experimental Physiology, EarlyView.Abstract Type 1 diabetes (T1D) is characterised by the loss of functional pancreatic β‐cells, for which lifelong insulin therapy remains the standard of care. Given that the gut microbiome can influence host health and that shifts in gut microbial profiles have been observed in T1D, growing interest has emerged in the role of the gut microbiome in T1D,
Shanti P. Kok +2 more
wiley +1 more source
HELZ directly interacts with CCR4–NOT and causes decay of bound mRNAs
Life Science Alliance, 2019 The putative UPF1-like SF1 helicase HELZ directly interacts with the CCR4–NOT deadenylase complex to induce translational repression and 5′-to-3′ decay of bound mRNAs. Eukaryotic superfamily (SF) 1 helicases have been implicated in various aspects of RNA
Aoife Hanet +10 more
doaj +1 more source
Consumer Cultural Renaissance: Conceptualisation, Scale Development, and Validation
Psychology &Marketing, Volume 43, Issue 11, Page 3178-3189, November 2026.ABSTRACT As incessant globalisation leads to the pervasive erosion of traditional Asian culture by Western consumerism, a recent phenomenon has emerged that allures Asian consumers to reconnect with their traditional culture via consumption. We postulate that this behaviour is rooted in a self‐identity, consumer cultural renaissance (CCR), that has not
Richard Lee +3 more
wiley +1 more source