Roles of the CCR4-Not complex in translation and dynamics of co-translation events. [PDF]
Wiley Interdiscip Rev RNA, 2023 Collart MA, Audebert L, Bushell M.
europepmc +1 more source
Roles of the yeast Ccr4‐Not complex in regulating transcription
The FASEB Journal, 2010 The highly conserved Ccr4‐Not complex has been ascribed many functions, from transcription regulation to mRNA decay. Initial studies described a role of this complex in preinitiation complex formation, but a number of studies have clearly shown Ccr4‐Not mediates deadenylation of mRNAs and
Arnob Dutta +3 more
openaire +1 more source
Nature Communications, 2016 The YTHDF family of proteins are able to bind and regulate the stability of methylated N6 RNA. Here the authors show that this decreased m6A RNA stability is mediated by direct recruitment of the CCR4–NOT deadenylase complex through YTHDF proteins.
Hao Du +7 more
doaj +1 more source
UNCOVERING THE MECHANISM OF CHROMATIN ASSOCIATION OF THE PAF1 TRANSCRIPTION ELONGATION COMPLEX [PDF]
, 2013 Paf1C co-localizes with Pol II and influences gene expression by regulating transcription initiation, elongation and termination. Some crucial functions of Paf1C include promoting co-transcriptional histone modifications and recruiting termination ...
Mayekar, Manasi
core
Etude structurale du complexe CCR4-NOT
, 2015 MRNA turnover begins with deadenylation where in the poly(A) tail at the 3’ end of the mRNA is removed. Deadenylation is the rate-limiting step of the decay pathway.
Basquin, Jérôme
core
Biochemical analysis of the nuclease module of the human Ccr4-Not deadenylase complex [PDF]
, 2015 In eukaryotic cells, the shortening and removal of the poly(A) tail (deadenylation) of cytoplasmic mRNA is a key step in mRNA degradation. The Ccr4-Not complex is well-characterised as a major deadenylase enzyme involved in mRNA deadenylation.
Maryati, Maryati
core
A dual, catalytic role for the fission yeast Ccr4-Not complex in gene silencing and heterochromatin spreading. [PDF]
Genetics, 2023 Challal D +5 more
europepmc +1 more source
The CCR4-NOT complex releases PABP from silenced miRNA targets in the absence of deadenylation
, 2013 GW182 family proteins interact with Argonaute proteins and are required for the translational repression, deadenylation and decay of miRNA targets. To elicit these effects, GW182 proteins interact with PABP and the CCR4- NOT deadenylase complex. Although
Zekri, L. +1 more
core
Biochemical analysis of the nuclease module of the human Ccr4-Not deadenylase complex [PDF]
In eukaryotic cells, the shortening and removal of the poly(A) tail (deadenylation) of cytoplasmic mRNA is a key step in mRNA degradation. The Ccr4-Not complex is well-characterised as a major deadenylase enzyme involved in mRNA deadenylation.
Maryati, Maryati
core +2 more sources
CCR4-NOT Complex 2-A Cofactor in Host Cell for Porcine Epidemic Diarrhea Virus Infection. [PDF]
Genes (Basel), 2022 Wang J +16 more
europepmc +1 more source