Results 111 to 120 of about 24,702 (192)

Expansion in CD39(+) CD4(+) Immunoregulatory T Cells and Rarity of Th17 Cells in HTLV-1 Infected Patients Is Associated with Neurological Complications [PDF]

, 2013
HTLV-1 infection is associated with several inflammatory disorders, including the neurodegenerative condition HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). It is unclear why a minority of infected subjects develops HAM/TSP.
A El Hed, A Gessain, Aaron M. Hasenkrug, AB Carneiro-Proietti, Aluisio C. Segurado, AM Vine, B Asquith, B Galvao-Castro, C Grant, CE Ormsby, CR Maliszewski, D Favre, DJ Hartigan-O'Connor, Douglas F. Nixon, E Bettelli, E Hanon, E Matsuura, EN Benveniste, Esper G. Kallas, F Annunziato, F Toulza, F Toulza, F Umehara, Fabio E. Leal, Fatah Kashanchi, Fernanda R. Bruno, G Borsellino, G de The, G Gaudray, G Raimondi, GP Garlet, H Kebir, Harry Wynn-Williams, HT Jin, I Best, I Elovaara, IM Stromnes, J Arnold, J Michaelsson, J Wang, JH Richardson, JM Brenchley, JM Fletcher, JR Orland, K Arisawa, K Eguchi, K Etoh, K Hieshima, K Nishioka, Karina I. Carvalho, KJ Livak, KM Dwyer, LC Ndhlovu, LC Ndhlovu, LC Ndhlovu, LC Ndhlovu, LE Harrington, Lishomwa C. Ndhlovu, M Bellon, M Hisada, M Matsuoka, M Mochizuki, M Nagai, M Osame, M Saito, MD Dodon, OS Morgan, P Hollsberg, PK Goon, Q Tang, R Iannone, R Kubota, R Kubota, R Tandon, S Deaglio, S Hilburn, S Read, S Sakaguchi, S Sakaguchi, Sabri S. Sanabani, SE Macatonia, SF Ziegler, T Lehner, T Ohsugi, T Usui, T Zhao, TF Greten, TR Mosmann, U Oh, Walter K. Neto, Y Koyanagi, Y Satou, Y Yamano, Y Yamano, Y Yamano, Y Yamano   +95 more
core   +4 more sources

Circular RNAs in Lotus japonicus Responses to Nutrient Supply and Mesorhizobium Symbiosis

Plant, Cell &Environment, EarlyView.
ABSTRACT Symbiotic interactions between legumes and rhizobia enable nitrogen fixation under low nutrient conditions. The establishment and function of symbiotic interactions require coordinated changes in gene expression in both the host and the microbe. Circular RNAs (circRNAs) are endogenous gene‐specific molecules that can regulate transcription and
Delecia Utley, Asa Budnick, Simona Radutoiu, Heike Sederoff   +3 more
wiley   +1 more source

Roles of the yeast Ccr4‐Not complex in regulating transcription

The FASEB Journal, 2010
The highly conserved Ccr4‐Not complex has been ascribed many functions, from transcription regulation to mRNA decay. Initial studies described a role of this complex in preinitiation complex formation, but a number of studies have clearly shown Ccr4‐Not mediates deadenylation of mRNAs and
Arnob Dutta, Jennifer A Kruk, David S Gilmour, Joseph C Reese   +3 more
openaire   +1 more source

Differential requirement for P2X7R function in IL-17 dependent vs. IL-17 independent cellular immune responses [PDF]

, 2014
IL17-dependent autoimmunity to collagen type V (Col V) has been associated with lung transplant obliterative bronchiolitis. Unlike the T helper 1 (Th1)-dependent immune responses to Tetanus Toxoid (TT), the Th17 response to Col V in lung transplant ...
Burlingham, W. J., Denlinger, L. C., Greenspan, D. S., Hegde, S., Jankowska-Gan, E., Roenneburg, D., Shi, L., Sullivan, J. A., Wilkes, D. S.   +8 more
core   +1 more source

Etiology, pathogenesis and treatment of peri‐implantitis: A European perspective

Periodontology 2000, EarlyView.
Abstract Peri‐implantitis is a plaque‐associated pathological condition occurring in tissues around dental implants. It is characterized by inflammation in the peri‐implant mucosa and progressive loss of supporting bone. Over the last 30 years, peri‐implantitis has become a major disease burden in dentistry.
Tord Berglundh, Andrea Mombelli, Frank Schwarz, Jan Derks   +3 more
wiley   +1 more source

A role for Q/N-rich aggregation-prone regions in P-body localization [PDF]

, 2008
P-bodies are cytoplasmic foci that are sites of mRNA degradation and translational repression. It is not known what causes the accumulation of RNA degradation factors in P-bodies, although RNA is required.
Alexander, R.D., Beggs, J.D., Reijns, M.A.M., Spiller, M.P.   +3 more
core   +1 more source

scMOG: A graph neural network method for regulatory relationship‐preserving single‐cell multi‐omics integration

Quantitative Biology, Volume 14, Issue 3, September 2026.
Abstract Single‐cell multi‐omics sequencing technology provides a powerful tool for studying cellular heterogeneity. However, beyond the challenges of sparsity, heterogeneity, and dimensionality differences, a critical challenge in multi‐omics data integration lies in preserving the true regulatory relationships among molecular features.
Yucheng Lu, Xun Zhang, Hongwei Li
wiley   +1 more source

Immune, molecular and genetic profiles of gastric signet ring cell carcinoma: Recent progress and future challenges

International Journal of Cancer, Volume 159, Issue 1, Page 11-29, 1 July 2026.
Abstract Gastric signet ring cell carcinoma (GSRCC) is a special type of gastric cancer common in young women. Diffuse gastric cancer (DGC) begins with intramucosal lesions comprising differentiated GSRCC cells. Genetically, GSRCC and DGC are clonally identical, with their morphology influenced by extracellular Wnt signaling.
Qian Wang, Shuai Zhou, Xiongchao Fang, Xianli He, Gang Wang, Nan Wang   +5 more
wiley   +1 more source

Human DDX6 regulates translation and decay of inefficiently translated mRNAs

eLife
Recent findings indicate that the translation elongation rate influences mRNA stability. One of the factors that has been implicated in this link between mRNA decay and translation speed is the yeast DEAD-box helicase Dhh1p.
Ramona Weber, Chung-Te Chang
doaj   +1 more source

1‐Hydroxy‐xanthine derivatives inhibit the human Caf1 nuclease and Caf1‐containing nuclease complexes via Mg2+‐dependent binding

FEBS Open Bio, 2019
In eukaryotic cells, cytoplasmic mRNA is characterised by a 3′ poly(A) tail. The shortening and removal of poly(A) tails (deadenylation) by the Ccr4‐Not nuclease complex leads to reduced translational efficiency and RNA degradation.
Blessing Airhihen, Lorenzo Pavanello, Gopal P. Jadhav, Peter M. Fischer, Gerlof Sebastiaan Winkler   +4 more
doaj   +1 more source