Results 111 to 120 of about 15,618 (178)
Ccr4‐Not complex directly regulates transcription elongation
The FASEB Journal, 2010 Many functions have been ascribed to the Ccr4‐Not complex. First described many years ago as a potential regulator of preinitiation complex (PIC) formation, more recently, a large body of evidence indicates it is predominantly cytoplasmic and regulates deadenylation of mRNA and ubiquitylation of substrates in ...
Joseph C Reese +3 more
openaire +1 more source
Roles of the CCR4-Not complex in translation and dynamics of co-translation events. [PDF]
Wiley Interdiscip Rev RNA, 2023 Collart MA, Audebert L, Bushell M.
europepmc +1 more source
Selective Depletion of Tumor‐Infiltrating CD4+CCR8+ Tregs by AZ084, a Novel CCR8 Antagonist
Cancer Science, Volume 117, Issue 10, Page 2719-2732, October 2026.AZ084, a novel CCR8 antagonist, selectively targets tumor‐infiltrating CD4+CCR8+ Tregs, reduces their immunosuppressive function, and decreases IL‐10/TGF‐β production. ABSTRACT Regulatory T cells (Tregs) are key mediators of immunosuppression in ovarian cancer, yet strategies for selectively targeting tumor‐infiltrating Tregs remain limited.
Yepeng Mao +12 more
wiley +1 more source
Roles of the yeast Ccr4‐Not complex in regulating transcription
The FASEB Journal, 2010 The highly conserved Ccr4‐Not complex has been ascribed many functions, from transcription regulation to mRNA decay. Initial studies described a role of this complex in preinitiation complex formation, but a number of studies have clearly shown Ccr4‐Not mediates deadenylation of mRNAs and
Arnob Dutta +3 more
openaire +1 more source
Experimental Physiology, Volume 111, Issue 10, Page 4507-4524, 1 October 2026.Abstract Sjögren's disease is an autoimmune disease characterized by severe dry eye, but its pathophysiology remains unclear. Non‐obese diabetic (NOD) mice develop Sjögren's disease‐like dry eye prior to the onset of diabetes. Although intestinal immune abnormalities precede diabetes in NOD mice, their relationship to dry eye remains poorly understood.
Kenji Goto +3 more
wiley +1 more source
Nature Communications, 2016 The YTHDF family of proteins are able to bind and regulate the stability of methylated N6 RNA. Here the authors show that this decreased m6A RNA stability is mediated by direct recruitment of the CCR4–NOT deadenylase complex through YTHDF proteins.
Hao Du +7 more
doaj +1 more source
The evolving role of immunotherapy in ovarian cancer
Cancer, Volume 132, Issue 18, 15 September 2026.Abstract Ovarian cancer remains a major cause of gynecologic cancer mortality; and, although immune checkpoint inhibitors have transformed treatment in other solid tumors, their activity in ovarian cancer has been limited by tumor heterogeneity, an immunosuppressive tumor microenvironment, and the lack of robust predictive biomarkers.
Ana Carolina Veneziani +2 more
wiley +1 more source
Biochemical characterisation of the human Ccr4-Not complex: core complex assembly and deadenylation activity [PDF]
Targeted degradation of cytoplasmic mRNA is of fundamental importance for regulated gene expression in eukaryotic cells. The shortening and removal of the poly(A) tail (deadenylation) is the initial and often rate-limiting step in this process.
Pavanello, Lorenzo
core +3 more sources
CNOT7 Outcompetes Its Paralog CNOT8 for Integration into The CCR4-NOT Complex [PDF]
The CCR4-NOT deadenylase complex is a major post-transcriptional regulator of eukaryotic gene expression. CNOT7 and CNOT8 are both vertebrate homologs of the yeast CCR4-NOT catalytic subunit Caf1.
Nishijima, Saori +3 more
core +1 more source
Etude structurale du complexe CCR4-NOT
, 2015 MRNA turnover begins with deadenylation where in the poly(A) tail at the 3’ end of the mRNA is removed. Deadenylation is the rate-limiting step of the decay pathway.
Basquin, Jérôme
core