Results 151 to 160 of about 87,303 (273)

A Mathematical Model for Allergic Reactions Induced by the Therapy of HIV

Mathematical Methods in the Applied Sciences, Volume 48, Issue 14, Page 13816-13838, 30 September 2025.
ABSTRACT A new mathematical model for cell evolution in HIV is introduced and studied. Delay differential equations are used to capture the dynamics of immune system cells involved in allergies, as well as the evolution of HIV viruses, infected and uninfected CD4 +$$ {}^{+} $$ cells, and cytotoxic T‐lymphocytes, under specific antiretroviral therapy ...
Rawan Abdullah, Florin Avram, Andrei Halanay, Rodica Radulescu   +3 more
wiley   +1 more source

Gene Organization and Promoter Function for CC Chemokine Receptor 5 (CCR5) [PDF]

, 1998
Florence Guignard, Christophe Combadière, H. Lee Tiffany, Philip M. Murphy   +3 more
openalex   +1 more source

The role of circular RNAs in regulating cytokine signaling in cancer

FEBS Open Bio, Volume 15, Issue 9, Page 1436-1458, September 2025.
Cytokines present in the tumor microenvironment fuel cancer development. Aberrant expression of circRNAs contributes to cancer progression. Cytokines are involved in regulating circRNA biogenesis. Furthermore, aberrantly expressed circRNAs regulate the expression of ligands, receptors, and downstream effectors involved in cytokine signaling to promote ...
Vandana Joshi, Swati, Amit Mishra, Amaresh Panda, Vivek Sharma   +4 more
wiley   +1 more source

CCR5 and CCL5 in metastatic colorectal cancer

Journal for ImmunoTherapy of Cancer
The CCR/L5 axis is known for its role in immune regulation in a variety of settings and has been shown to have dichotomous functions in cancer, influencing both tumor progression and immune responses. Battaglin et al investigated its role using genomic and transcriptomic data from several datasets of patients with advanced colorectal cancer (CRC ...
Benjamin L Schlechter, Justin Stebbing
openaire   +3 more sources

Expanded Tropism of Primary Human Immunodeficiency Virus Type 1 R5 Strains to CD4 ⁺ T-Cell Lines Determined by the Capacity To Exploit Low Concentrations of CCR5 [PDF]

, 1999
Nathalie Dejucq‐Rainsford, Graham Simmons, Paul R. Clapham   +2 more
openalex   +1 more source

H3K36me3‐Guided m6A Modification of Oncogenic L1CAM‐AS1 Drives Macrophage Polarization and Immunotherapy Resistance in Hepatocellular Carcinoma

Advanced Science, Volume 12, Issue 33, September 4, 2025.
L1CAM‐AS1 is identified as a novel H3K36me3‐guided, m6A‐modified long noncoding RNA (lncRNA) in hepatocellular carcinoma (HCC) cells. L1CAM‐AS1 stabilizes RAN protein, enhances M2 macrophages‐released CCL5‐induced nuclear import of RELA, activates the NF‐κB signaling, up‐regulates CCL2 expression and secretion from HCC cells, and enhances M2 ...
Teng Wang, Linyu Han, Yanfei Huo, Long Zhang, Yizhou Huang, Nasha Zhang, Ming Yang   +6 more
wiley   +1 more source

Triplex targeting of a native gene in permeabilized intact cells: covalent modification of the gene for the chemokine receptor CCR5 [PDF]

, 1998
Evgeniy Belousov
openalex   +1 more source

Activity and Heterogeneity of Astrocytes in Neurological Diseases: Molecular Mechanisms and Therapeutic Targets

MedComm, Volume 6, Issue 9, September 2025.
Astrocytes display heterogeneity in various neurological disorders and behavioral neuropsychiatric disorders. Astrocytes influence the progression of neurological diseases through neuroinflammation, oxidative stress, metabolic abnormalities, intercellular interactions, and a spectrum of other pathophysiological processes.
Shijie Mao, Rui Qiao, Qi Wang, Ling Shen, Daxing Li, Xinchen Huo, Jindou Wang, Kunxuan Liu, Wenjing Chen, Tianhao Zhu, Beicheng Zhang, Shuo Leng, Ying Bai   +12 more
wiley   +1 more source

CCR5/Δccr5 Heterozygosity: A Selective Pressure for the Syncytium‐Inducing Human Immunodeficiency Virus Type 1 Phenotype [PDF]

, 1998
Richard T. D’Aquila, Lorraine Sutton, Anu V. Savara, Michael D. Hughes, Victoria A. Johnson   +4 more
openalex   +1 more source

Go for Gold: Development of a Scalable Synthesis of [1‐(Ethoxycarbonyl)cyclopropyl] Triphenylphosphonium Tetrafluoroborate, a Key Reagent to Explore Covalent Monopolar Spindle 1 Inhibitors

ChemistryOpen, Volume 14, Issue 9, September 2025.
[1‐(Ethoxycarbonyl)cyclopropyl] triphenylphosphonium tetrafluoroborate is a limiting key reagent for synthesis of the tricyclic 5,6‐dihydropyrimido[5,4‐e]indolizine and related scaffolds, which are central to First‐in‐Class covalent inhibitors of the protein kinase monopolar spindle 1/threonine tyrosine kinase (TTK).
Leon Rebhan, Rebekka Fürst, Dieter Schollmeyer, Ricardo A. M. Serafim, Matthias Gehringer   +4 more
wiley   +1 more source