Results 191 to 200 of about 82,628 (226)

No change in key HIV target cell markers following initiation of three progestin-based hormonal contraception methods: findings from the CHIME study. [PDF]

open access: yesFront Immunol
Young MR   +9 more
europepmc   +1 more source

Impact of <i>Wuchereria bancrofti</i> Infection on Cervical Mucosal Immunity and Human Papillomavirus Prevalence in Women from Lindi and Mbeya Regions, Tanzania. [PDF]

open access: yesTrop Med Infect Dis
Mosoba M   +19 more
europepmc   +1 more source

The Chimeric Nuclease SpRYc Exhibits Highly Variable Performance Across Biological Systems. [PDF]

open access: yesInt J Mol Sci
Deriglazova IO   +4 more
europepmc   +1 more source
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Spiropiperidine CCR5 antagonists

Bioorganic & Medicinal Chemistry Letters, 2009
A novel series of CCR5 antagonists has been identified, utilizing leads from high-throughput screening which were further modified based on insights from competitor molecules. Lead optimization was pursued by balancing opposing trends of metabolic stability and potency. Selective and potent analogs with good pharmacokinetic properties were successfully
David M, Rotstein   +17 more
openaire   +2 more sources

CCR5 and HIV Infection

Receptors and Channels, 2002
Chemokines and chemokine receptors play a crucial role in the trafficking of leukocyte populations across the body, and are involved in the development of a large variety of human diseases. CCR5 is the main coreceptor used by macrophage (M)-tropic strains of human immunodeficiency virus type 1 (HIV-1) and HIV-2, which are responsible for viral ...
Blanpain, Cédric   +3 more
openaire   +2 more sources

The chemokine receptor, CCR5

The International Journal of Biochemistry & Cell Biology, 2004
The chemokine receptor, CCR5, is a G protein coupled receptor responsible for some of the effects of the chemokines CCL3, CCL4 and CCL5. It is also one of the co-receptors for the entry of human immunodeficiency virus-1 (HIV-1) into cells. Regulation of CCR5 number on cells is, therefore, important for determining the infection rate by HIV-1.
Mueller, A., Strange, P. G.
openaire   +3 more sources

CCR5-Maraviroc Structure

Science, 2013
The crystal structure of the HIV co-receptor CCR5 bound to the HIV drug maraviroc provides insight into how HIV enters cells.
openaire   +2 more sources

CCR5 and inflammatory storm

Ageing Research Reviews
Chemokines and their corresponding receptors play crucial roles in orchestrating inflammatory and immune responses, particularly in the context of pathological conditions disrupting the internal environment. Among these receptors, CCR5 has garnered considerable attention due to its significant involvement in the inflammatory cascade, serving as a ...
Yuting Lin   +19 more
openaire   +2 more sources

Lymphocyte adhesion to CCR5 ligands is reduced by anti-CCR5 gene delivery

Journal of the Neurological Sciences, 2011
Immune-mediated damage to the central nervous system (CNS) is an important contributor to many CNS diseases, including epilepsy. Chemokines play a role in leukocyte recruitment to, and migration across, the blood-brain barrier (BBB) during many such processes. We previously investigated the role of the chemokine receptor CCR5 in a rat model of epilepsy
Elena, Marusich   +3 more
openaire   +2 more sources

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