Results 61 to 70 of about 87,303 (273)

Current trends and future of gene-cell immunotherapy in the treatment of HIV infection

Онкогематология
Despite significant advancements in antiretroviral therapy, HIV viral reservoirs continue to persist even in patients receiving combination therapy. In recent years, promising results have emerged in HIV treatment, including two cases of functional cure ...
A. P. Faenko, G. A. Dudina, Ch. K. Mabudzade, A. A. Ogannisyan   +3 more
doaj   +1 more source

CCR5 status and metastatic progression in colorectal cancer

OncoImmunology, 2019
Multiple reports have highlighted the importance of the local immunological cellular composition (i.e. the density of effector T cells and macrophage polarization state) in predicting clinical outcome in advanced metastatic stage of colorectal cancer ...
Meggy Suarez-Carmona, Pornpimol Chaorentong, Jakob Nikolas Kather, Rebecca Rothenheber, Azaz Ahmed, Anna Berthel, Anita Heinzelmann, Rodrigo Moraleda, Nektarios A. Valous, Zeynep Kosaloglu, Rosa Eurich, Jana Wolf, Silke Grauling-Halama, Michael Hundemer, Felix Lasitschka, Fee Klupp, Christoph Kahlert, Alexis Ulrich, Martin Schneider, Christine Falk, Dirk Jäger, Inka Zoernig, Niels Halama   +22 more
doaj   +1 more source

Differential Pathogenicity of SHIV KB9 and 89.6 Env Correlates with Bystander Apoptosis Induction in CD4+ T cells

Viruses, 2019
SHIV variants KB9 and 89.6 show differential pathogenesis in primate models with KB9 causing rapid CD4 decline while 89.6 failing to induce disease.
Tugba Mehmetoglu-Gurbuz, Anjali Joshi, Himanshu Garg   +2 more
doaj   +1 more source

A guide to chemokines and their receptors [PDF]

, 2018
The chemokines (or chemotactic cytokines) are a large family of small, secreted proteins that signal through cell surface G‐protein coupled heptahelical chemokine receptors.
Braun A, Dyer DP, Garton KJ, Gupta SK, Hundelshausen P, Janssens R, Murphy PM, Sozzani S, Speck RF, Suan D, Woollard SM, Zheng Y   +11 more
core   +1 more source

Genetic Engineering Methods in Primary T Cells

Advanced Therapeutics, EarlyView.
Primary T cells can be engineered to confer them with novel therapeutic functions, allowing them to treat a variety of conditions. Genetic engineering can be either stable or transient, aiming to either express or inhibit a target gene. This review discusses the various genetic engineering tools available as well as their characteristics and ...
Anthony Youssef, Hui‐Shan Li
wiley   +1 more source

CCR5 is essential for NK cell trafficking and host survival following Toxoplasma gondii infection. [PDF]

PLoS Pathogens, 2006
The host response to intracellular pathogens requires the coordinated action of both the innate and acquired immune systems. Chemokines play a critical role in the trafficking of immune cells and transitioning an innate immune response into an acquired ...
Imtiaz A Khan, Seddon Y Thomas, Magali M Moretto, Frederick S Lee, Sabina A Islam, Crescent Combe, Joseph D Schwartzman, Andrew D Luster   +7 more
doaj   +1 more source

Scaffolding Protein ENH Promotes Tumor Angiogenesis and Growth Through Macrophage Recruitment and Polarization

Advanced Science, EarlyView.
In tumor cells, ENH prompts the interaction between YAP and KPNA2. This interaction enables YAP to translocate into the nucleus, where it enhances the transcription of CCL5. Consequently, this up‐regulation of CCL5 drives the infiltration of tumor‐associated macrophages (TAMs) and their polarization toward the M2 phenotype, ultimately facilitating ...
Yueli Shi, Zhiyong Xu, Huan Wang, Bufu Tang, Nueraili Maihemuti, Xinyuan Jiang, Xiuying Chen, Mingshu Xiao, Sujing Jiang, Yun Xu, Peng Xiao, Jiangnan Zhao, Kaiyue Zhang, Mengshu Li, Kai Wang   +14 more
wiley   +1 more source

Constrained use of CCR5 on CD4+ lymphocytes by R5X4 HIV-1: Efficiency of Env–CCR5 interactions and low CCR5 expression determine a range of restricted CCR5-mediated entry

Virology, 2010
R5X4 HIV-1 has impaired utilization of CCR5 on primary CD4+ lymphocytes but the mechanisms responsible are not well defined. Using a panel of diverse R5X4 Envs we identified a spectrum of CCR5 use on CD4+ lymphocytes. Greater lymphocyte CCR5 use correlated with relative resistance to CCR5 mAbs and small molecule antagonists.
Paul R Gorry, Benhur Lee, Martha Kienzle, Lamorris M Loftin, Yanjie Yi, Ronald G. Collman, Lachlan Robert Gray, Fang-Hua Lee   +7 more
openaire   +3 more sources

A functional interaction between the CCR5 and CD34 molecules expressed in hematopoietic cells can support (or even promote) the development of cancer

Hematology, Transfusion and Cell Therapy, 2020
Inflammation and angiogenesis are linked to the development of cancer since both can support the establishment of a tumor-prone microenvironment. The CCR5 is a major regulatory molecule involved in inflammation. The CD34 molecule is commonly described as
Bruna Kulmann-Leal, Joel Henrique Ellwanger, José Artur Bogo Chies   +2 more
doaj   +1 more source

Characterization of designed, synthetically accessible bryostatin analog HIV latency reversing agents. [PDF]

, 2018
HIV latency in resting CD4+ T cell represents a key barrier preventing cure of the infection with antiretroviral drugs alone. Latency reversing agents (LRAs) can activate HIV expression in latently infected cells, potentially leading to their elimination
DeChristopher, Brian A, Hardman, Clayton T, Ho, Stephen, Loy, Brian A, Marsden, Matthew D, Navab, Sara M, Ramirez, Christina M, Schrier, Adam J, Shimizu, Akira J, Wender, Paul A, Wu, Xiaomeng, Zack, Jerome A   +11 more
core   +1 more source