Results 61 to 70 of about 90,382 (271)

Mapping the complete glycoproteome of virion-derived HIV-1 gp120 provides insights into broadly neutralizing antibody binding [PDF]

, 2016
The surface envelope glycoprotein (SU) of Human immunodeficiency virus type 1 (HIV-1), gp120SU plays an essential role in virus binding to target CD4+ T-cells and is a major vaccine target.
Bess, JW, Binet, D, Bouché, L, Canis, K, Chertova, E, Dell, A, Desrosiers, RC, Haslam, SM, Keele, BF, Lifson, JD, Morris, HR, North, SJ, O'Connor, MJ, Pang, PC, Panico, M, Rahman, D   +15 more
core   +1 more source

CCR5 saves lives [PDF]

The Journal of Experimental Medicine, 2005
![Graphic][1] CCR5 + mononuclear cells (black) infiltrate the brain and help eliminate WNV infection.Although West Nile virus (WNV) infections have made headlines in recent years, little is known about how the virus causes disease or how the immune system fights back.
openaire   +1 more source

Loss of SOCS1 in Donor T Cells Exacerbates Intestinal GVHD by Driving a Chemokine‐Dependent Pro‐Inflammatory Immune Microenvironment

Advanced Science, EarlyView.
T cell‐specific Socs1 knockout leads to inflammatory differentiation of CD8+ T cells, prompting the STAT1/2 complex to drive the activation of Ccl5, Ccr5, and Cxcr3, and promoting the skewing of monocytes toward a pro‐inflammatory M1 macrophage lineage.
Zhigui Wu, Bixia Wang, Xinya Jiang, Fangqing Zhang, Qianqian Huang, Xinyi Wu, Shuang Fan, Qi Zhang, Jingrui Zhou, Jianing Tang, Xiao‐Dong Mo, Yu Wang, Ying‐Jun Chang, Huidong Guo, Xiao‐Jun Huang   +14 more
wiley   +1 more source

Supplementary Materials and Methods from Enriching the Housing Environment for Mice Enhances Their NK Cell Antitumor Immunity via Sympathetic Nerve–Dependent Regulation of NKG2D and CCR5 [PDF]

, 2023
Yanfang Song, Yu Gan, Qing Wang, Zihong Meng, Guohua Li, Yuling Shen, Yufeng Wu, Peiying Li, Ming Yao, Jianren Gu, Hong Tu   +10 more
openalex   +2 more sources

Downregulation of CCR5 on brain perivascular macrophages in simian immunodeficiency virus‐infected rhesus macaques

Brain and Behavior, 2023
Background C‐C chemokine receptor 5 (CCR5) is a major coreceptor for Human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) cell entry; however, its role in brain pathogenesis is largely understudied.
Julian B. Hattler, Derek L. Irons, Jiangtao Luo, Woong‐Ki Kim   +3 more
doaj   +1 more source

Upregulation of surface feline CXCR4 expression following ectopic expression of CCR5: implications for studies of the cell tropism of feline immunodeficiency virus [PDF]

, 2002
Feline CXCR4 and CCR5 were expressed in feline cells as fusion proteins with enhanced green fluorescent protein (EGFP). Expression of the EGFP fusion proteins was localized to the cell membrane, and surface expression of CXCR4 was confirmed by using a ...
Cannon, C.A., Hosie, M.J., Willett, B.J.
core   +2 more sources

Engineering Compact Base Editors by AlphaFold‐Guided Mutation Scan and Escherichia coli‐Based Tri‐Selection

Advanced Science, EarlyView.
A miniaturized deaminase SsdAtox was scanned with AlphaFold to identify DNA binding pocket hot spots. Site‐saturation mutagenesis at gatekeeper residue K31 yielded ten‐fold activity enhancement. Trinity Screen, an E. coli‐based three‐in‐one platform selecting for high activity and reduced double‐strand breaks, enabled combinatorial evolution at DNA ...
Ryeo Gang Son, Goeun Kim, Jungjoon K. Lee   +2 more
wiley   +1 more source

HIV-1 predisposed to acquiring resistance to maraviroc (MVC) and other CCR5 antagonists in vitro has an inherent, low-level ability to utilize MVC-bound CCR5 for entry

Retrovirology, 2011
Background Maraviroc (MVC) and other CCR5 antagonists are HIV-1 entry inhibitors that bind to- and alter the conformation of CCR5, such that CCR5 is no longer recognized by the viral gp120 envelope (Env) glycoproteins.
Westby Mike, Jubb Becky, Salimiseyedabad Hamid, Ellett Anne, Jakobsen Martin R, Roche Michael, Lee Benhur, Lewin Sharon R, Churchill Melissa J, Gorry Paul R   +9 more
doaj   +1 more source

Targeting IL27RA Enhances Immunotherapy in Triple‐Negative Breast Cancer by Modulating Tumor Cells and the Tumor Microenvironment

Advanced Science, EarlyView.
IL27RA upregulation drives immune evasion in TNBC by suppressing MHC‐I expression and reprogramming T/NK‐cell states, establishing an immune‐excluded tumor phenotype. Targeting this epithelial‐intrinsic IL27RA–PI3K/AKT axis offers a promising strategy to overcome immunotherapy resistance.
Jiachi Xu, Qian Long, Meirong Zhou, Qitong Chen, Jing Peng, Qingchun Liang, Danhua Zhang, Hui Zhou, Wenjun Yi   +8 more
wiley   +1 more source

Genome editing technologies to fight infectious diseases [PDF]

, 2017
Genome editing by programmable nucleases represents a promising tool that could be exploited to develop new therapeutic strategies to fight infectious diseases.
Barzon, Luisa, Pal\ue3\ub9, Giorgio, Trevisan, Marta   +2 more
core   +1 more source