Results 91 to 100 of about 17,756 (247)

Human Bronchial Epithelial Cells Induce CD141/CD123/DC-SIGN/FLT3 Monocytes That Promote Allogeneic Th17 Differentiation [PDF]

, 2017
Little is known about monocyte differentiation in the lung mucosal environment and about how the epithelium shapes monocyte function. We studied the role of the soluble component of bronchial epithelial cells (BECs) obtained under basal culture ...
Anne Wilson, Katrin Hostettler, Cesson, Valerie, Valerie Cesson, Aubert, John David, Carolina Obregon, Laurent P. Nicod, Lazor, Romain, Blank, Fabian, Gazdhar, Amiq, John David Aubert, Amiq Gazdhar, Obregon, Carolina, Nicod, Laurent P, Romain Lazor, Spertini, Francois, Fabian Blank, Hostettler, Katrin, Alban Lovis, Wilson, Anne, Lovis, Alban, Francois Spertini   +21 more
core   +2 more sources

Augmented Expression of the IL3RA/CD123 Gene in MLL/KMT2A-Rearranged Pediatric AML and Infant ALL

, 2022
Here, we evaluated transcript-level IL3RA/CD123 expression in mixed lineage leukemia 1 (MLL) gene/KMT2A-rearranged (MLL-R+) vs. MLL-R− pediatric AML as well as infant ALL by comparing the archived datasets of the transcriptomes of primary leukemic ...
Sanjive Qazi, Fatih M. Uckun
core   +1 more source

High CD123 levels enhance proliferation in response to IL-3, but reduce chemotaxis by downregulating CXCR4 expression

Blood Advances, 2017
: High expression of the α chain of the interleukin-3 receptor (IL-3Rα; CD123) is a hallmark of acute myeloid leukemia (AML) leukemic stem cells (LSCs). Elevated CD123 expression is part of the diagnostic immunophenotyping of myeloid leukemia, and higher
Nicole L. Wittwer, Gabriela Brumatti, Ceilidh Marchant, Jarrod J. Sandow, Melanie K. Pudney, Mara Dottore, Richard J. D'Andrea, Angel F. Lopez, Paul G. Ekert, Hayley S. Ramshaw   +9 more
doaj   +1 more source

Cutaneous involvement by myeloid leukaemias: challenging cases with important implications

Histopathology, EarlyView.
Myeloid leukaemias and precursors involving the skin are often challenging to diagnose with varied and overlapping clinical and histopathologic features. Nonetheless, they are critical for pathologists to recognize and accurately classify. This review discusses the clinical, histopathological and genetic features of myelodysplasia cutis (A) and ...
Alexandra C. Hristov
wiley   +1 more source

ICSH Guidance on Bone Marrow Examination and Reporting

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Examination of the bone marrow (BM) remains fundamental to the diagnosis, classification, prognostication, and monitoring of hematolymphoid and other disorders affecting blood cell production. Since publication of the International Council for Standardization in Haematology (ICSH) guideline in 2008, advances in diagnostic technologies, disease
Wendy N. Erber, Alexandar Tzankov, Olga Pozdnyakova, Hiromichi Matsushita, Gina Zini, Leonie Saft, on behalf of the International Council for Standardization in Haematology   +6 more
wiley   +1 more source

Redirecting T Cells With Chimeric Antigen Receptors to Target Cd123+ Leukemia [PDF]

, 2015
ABSTRAC REDIRECTING T CELLS WITH CHIMERIC ANTIGEN RECEPTORS TO TARGET CD123+ LEUKEMIA Radhika Thokala, Ph.D* Advisory Professor: Dean Anthony Lee, M.D, Ph.D CD123 or interleukin receptor alpha (IL-3Rα) is expressed on hematological malignancies such as ...
Thokala, Radhika
core   +1 more source

Investigation of IgM Monoclonal Paraprotein in Bone Marrow Aspiration: The Role of Immunophenotyping by Flow Cytometry in Selecting Cases for Molecular Testing for the p.MYD88 L265P Point Mutation

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Background Flow cytometry and real‐time quantitative polymerase chain reaction (qRT‐PCR) for MYD88 mutations (MYD88mt) are routinely performed on bone marrow aspirates during the diagnostic evaluation of IgM monoclonal paraproteinemia. The potential predictive value of immunophenotypic findings for molecular results, however, remains to be ...
Georgios Boutsikas, Konstantinos Agiannitopoulos, Elisavet Kouvidi, Myrto Katraki, Athanasios Papatheodorou, Anna Roussou, Nikolaos Paschalidis, Theodoros P. Vassilakopoulos, Ioannis Anagnostopoulos, Dimitra Sasaroli, Aglaia Dimitrakopoulou   +10 more
wiley   +1 more source

The expression of CD123 can decrease with basophil activation: implications for the gating strategy of the basophil activation test [PDF]

, 2016
Background: Basophil activation test (BAT) reproduces IgE-mediated allergic reactions in vitro and has been used as a diagnostic test. Different markers can be used to identify basophils in whole blood and have implications for the outcome of the test ...
Gideon Lack, Santos, Alexandra F., Stephens, Alick, Alick Stephens, Turcanu, Victor, Bécares, Natalia, Natalia Bécares, Alexandra F. Santos, Victor Turcanu, Lack, Gideon   +9 more
core   +1 more source

Morphological and immunohistochemical (CD4/CD8 T cell and CD123(+) plasmacytoid dendritic cell ratios) comparative analysis of rosacea, discoid lupus erythematosus, and polymorphous light eruption lesions

Indian Journal of Pathology and Microbiology
Background: Rosacea, discoid lupus erythematosus (DLE), and polymorphous light eruption (PLE) can present with overlapping clinical and histopathological features.
Ozge Aydin, Fahriye Kilinc
doaj   +1 more source

Blastic plasmacytoid dendritic cell neoplasia - a rare type of acute leukemia

Romanian Journal of Laboratory Medicine, 2014
Neoplasmul cu celule dendritice plasmocitoide blastice (NCDPB), clasificat recent în grupul leucemiilor acute mieloide este o boală hematologică malignă rară cu evoluţie clinică extrem de agresivă.
Köpeczi Judit Beáta, Benedek Erzsébet, Kakucs Enikő, Tunyogi Aliz, Istrati Monica, Benedek Istvan   +5 more
doaj   +1 more source