Results 91 to 100 of about 14,385 (213)

Generating and Expanding Conventional Type 1 Dendritic Cells

European Journal of Immunology, Volume 56, Issue 10, October 2026.
Conventional type 1 dendritic cells (cDC1s) are difficult to obtain in sufficient numbers. This Review compares strategies based on progenitor differentiation, cell programming, or expansion in tissues, and shows how differences in cell identity, population composition, function, and yield should guide platform selection.
Sukriti Sharma, Shandré Pillay, Christian T. Mayer   +2 more
wiley   +1 more source

Daunorubicin-Loaded CdTe QDs Conjugated with Anti-CD123 mAbs: A Novel Delivery System for Myelodysplastic Syndromes Treatment

International Journal of Nanomedicine, 2020
Dan Guo,1,2 Peipei Xu,1 Dangui Chen,1 Lili Wang,1 Yudi Zhu,1 Yifan Zuo,1 Bing Chen1 1Department of Hematology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu 210093, People’s Republic of ...
Guo D, Xu P, Chen D, Wang L, Zhu Y, Zuo Y, Chen B   +6 more
doaj  

A platform of serially transplantable AML PDX models covering subgroups for which no cell lines exist

HemaSphere, Volume 10, Issue 10, October 2026.
Abstract Acute myeloid leukemia (AML) is a highly aggressive malignancy with poor prognosis, underlining the need for suitable model systems to develop novel treatments. To complement the few existing AML cell lines and restricted primografts, we transplanted more than 100 primary AML samples into immunocompromised mice and generated 23 exceptionally ...
Binje Vick, Vindi Jurinovic, Kristina Kuhbandner, Lena Lagally, Lisa Latzko, Chiara Arnreich, Gerulf Hänel, Amelie Muth, Maximilian Schönung, Arnold Kloos, Maja Rothenberg‐Thurley, Annika M. Dufour, Stephanie Schneider, Lesca M. Holdt, Liliana Mura, Fabian Klein, Annette Frank, Dhruv Mehra, Annika Fröhlich, Johannes W. Bagnoli, Maya C. André, Claudia D. Baldus, Martin Carroll, Christine Dierks, Martin Ebinger, Katharina S. Götze, Pablo Menéndez, Christian Récher, Ambrine Sahal, Jean‐Emmanuel Sarry, Christian Thiede, Talía Velasco‐Hernández, Xiaoyan Wei, Jan H. Klusmann, Wolfgang Enard, Michael von Bergwelt‐Baildon, Wolfgang Hiddemann, Klaus H. Metzeler, Philipp A. Greif, Michael Heuser, Daniel B. Lipka, Marion Subklewe, Sebastian Vosberg, Tobias Herold, Karsten Spiekermann, Irmela Jeremias   +45 more
wiley   +1 more source

Redirecting T Cells With Chimeric Antigen Receptors to Target Cd123+ Leukemia [PDF]

, 2015
ABSTRAC REDIRECTING T CELLS WITH CHIMERIC ANTIGEN RECEPTORS TO TARGET CD123+ LEUKEMIA Radhika Thokala, Ph.D* Advisory Professor: Dean Anthony Lee, M.D, Ph.D CD123 or interleukin receptor alpha (IL-3Rα) is expressed on hematological malignancies such as ...
Thokala, Radhika
core   +1 more source

RELATIONSHIP BETWEEN THE EXPRESSION OF CD34, CD123 AND MYELOPEROXIDASE MARKERS BY FLOW CYTOMETRY AND RESPONSE TO INDUCTION THERAPY IN ACUTE MYELOID LEUKEMIA

The Iraqi Journal of Medical Sciences, 2016
Background:Different immunophenotypic markers were found to be related to the prognosis of acute myeloid leukemia. Among them are CD34, CD123 and myeloperoxidase.
Faez Sh. Almohsen, Subh S. Al-Mudallal
doaj   +4 more sources

Molecular, Cytogenetic, and Immunophenotypic Biomarkers in Acute Myeloid Leukemia: Current Evidence and Future Directions—A Narrative Review

Health Science Reports, Volume 9, Issue 10, October 2026.
ABSTRACT Background Acute myeloid leukemia (AML) is a highly heterogeneous hematologic malignancy with variable clinical behavior and outcomes. Conventional morphology‐based classification is insufficient to capture this complexity, necessitating the use of molecular, cytogenetic, and immunophenotypic biomarkers for accurate diagnosis, risk ...
Emmanuel Ifeanyi Obeagu
wiley   +1 more source

Advances in γδ T Cells: Cutaneous Biology and Therapeutic Potential for Skin Neoplasms

The Journal of Dermatology, Volume 53, Issue 10, Page 1415-1428, October 2026.
ABSTRACT γδ T cells represent an increasingly important subset of T lymphocytes in the immune response to cancer and as a platform for novel immunotherapies. The aim of this review is to synthesize recent insights into the biology and advances in therapeutic applications of γδ T cells in cutaneous malignancies, especially melanoma, within a framework ...
Simo Du, Anika Jallorina, Toru Yoshino, Lingyu Bao, Han Bao, Victor Chang, Henry K. Wong, Derek V. Chan, Stephen K. Richardson, Mary F. Lee‐Wong   +9 more
wiley   +1 more source

Allogeneic hematopoietic cell transplantation as the standard of care for blastic plasmacytoid dendritic cell neoplasm in first complete remission

Hematology/Oncology and Stem Cell Therapy
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematologic disorder derived from precursors of plasmacytoid dendritic cells, with a generally aggressive clinical course.
Mohamed A. Kharfan-Dabaja
doaj   +1 more source

Recent developments in the treatment of blastic plasmacytoid dendritic cell neoplasm

Therapeutic Advances in Hematology, 2019
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a clinically aggressive hematologic malignancy derived from precursors of dendritic cells and involves most frequently the skin, bone marrow and lymph nodes. Diagnosis depends upon identification of
Minas P. Economides, Marina Konopleva, Naveen Pemmaraju   +2 more
doaj   +1 more source

β‐Catenin‐Deficient Intervertebral Disc Cells Reduce Chemotactic Transcription and Myeloid Cell Recruitment to Injured Discs of Mice

Aging Cell, Volume 25, Issue 10, October 2026.
(Left) In young discs, Wnt signaling‐replete nucleus pulposus cells secrete ECM components and, upon disc injury, cytokines to recruit myeloid cells. (Right) Whereas, β‐catenin‐deficient disc cells, modeling age‐related absence of Wnt signaling, exhibit reduced anabolic activity and, upon disc injury, secrete fewer pro‐inflammatory cytokines and ...
Tori M. Kroon, Jazz Munitz, Anna Ranzenigo, Martin Umali, William Wang, Jonathan J. Huang, Abraham J. P. Teunissen, Nilsson Holguin   +7 more
wiley   +1 more source