Results 71 to 80 of about 17,756 (247)

CD123-directed allogeneic chimeric-antigen receptor T-cell therapy (CAR-T) in blastic plasmacytoid dendritic cell neoplasm (BPDCN): Clinicopathological insights.

Leukemia research : a Forum for Studies on Leukemia and Normal Hemopoiesis, 2022
PURPOSE Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a hematologic malignancy associated with overexpression of CD123. Allogeneic chimeric antigen receptor T cells (CAR-T) directed against CD123 in BPDCN have been studied in clinical trials ...
Naveen Pemmaraju, N. Wilson, J. Senapati, Minas P. Economides, M. Guzman, S. Neelapu, Rossana Kazemimood, R. Davis, N. Jain, J. Khoury, M. Sugita, Tian-Yu Cai, Julianne N. P. Smith, M. Frattini, A. Garton, G. Roboz, M. Konopleva   +16 more
semanticscholar   +1 more source

CD123 immunoexpression in cutaneous lupus erythematosus, polymorphous light eruption, pityriasis rosea, and mycosis fungoides

, 2021
Introduction: CD123-positive plasmacytoid dendrocytes are prominent in the infiltrate of cutaneous lupus erythematous. Aim: To determine the significance of the CD123 immunostain, which labels plasmacytoid dendritic cells (PDC), in cutaneous lupus ...
Büyücek, Şeyma, Coşkun, Sinem, Gamsızkan, Mehmet, Karagün, Ebru   +3 more
core   +1 more source

Lupus Panniculitis Immunoprofiling Reveals a Cytotoxic, Type 1‐Skewed T‐Cell Response With Signs of Metabolic Alteration

Allergy, EarlyView.
Imaging mass cytometry shows lupus panniculitis lesions are dominated by cytotoxic and skin‐homing T cells with abundant macrophages and B‐cell aggregates. Spatial neighborhood analysis reveals organized leukocyte architecture, including B‐cell proximity to naïve T cells and M1 macrophages to cytotoxic T cells.
Milad Ameri, Reihane Ziadlou, Stephan Traidl, Milena Sokolowska, Emmanuel Contassot, Nick Li, Maija Kiuru, Isabel Kolm, Werner Kempf, Emanual Maverakis, Cezmi Akdis, Marie‐Charlotte Brüggen   +11 more
wiley   +1 more source

Interleukin-3 receptor alpha chain (CD123) is widely expressed in hematologic malignancies

Haematologica, 2001
BACKGROUND AND OBJECTIVES: The hematopoietic system is controlled by growth factors (cytokines) which can influence cell survival, proliferation, differentiation and functional activation. The study of cytokine receptor expression by flow cytometry could
L Munoz, JF Nomdedeu, O Lopez, MJ Carnicer, M Bellido, A Aventin, S Brunet, J Sierra   +7 more
doaj  

Loop33 × 123 CAR-T targeting CD33 and CD123 against immune escape in acute myeloid leukemia

Cancer Immunology and Immunotherapy
Immunotherapy, such as chimeric antigen receptor T (CAR-T) cells targeting CD33 or CD123, has been well developed over the past decade for the treatment of acute myeloid leukemia (AML).
Haotian Ma, Zhifeng Yan, Run-Xia Gu, Yingxi Xu, S. Qiu, H. Xing, K. Tang, Zheng Tian, Q. Rao, Min Wang, Jian-Xiang Wang   +10 more
semanticscholar   +1 more source

CD123 Expression Is Associated With High-Risk Disease Characteristics in Childhood Acute Myeloid Leukemia: A Report From the Children's Oncology Group

Journal of Clinical Oncology, 2021
PURPOSE Increased CD123 surface expression has been associated with high-risk disease characteristics in adult acute myeloid leukemia (AML), but has not been well-characterized in childhood AML.
A. Lamble, Lisa Eidenschink Brodersen, T. Alonzo, Jim Wang, L. Pardo, L. Sung, T. Cooper, E. Kolb, R. Aplenc, Sarah K. Tasian, M. Loken, S. Meshinchi   +11 more
semanticscholar   +1 more source

Basophils in Immunity: Activation Pathways, Roles in Allergy and AllergoOncology and Application of the Basophil Activation Test

Allergy, EarlyView.
ABSTRACT Basophils, the least abundant leukocytes, are increasingly recognised as potent immunomodulators. Upon activation, they rapidly release preformed granule‐associated mediators including histamine and lipid mediators such as LTC4, while cytokine production occurs over a longer timescale, contributing to downstream immune responses.
Jitesh Chauhan, Sofia Vlasova, Alicia Chenoweth, Debra H. Josephs, Heather J. Bax, Sophia N. Karagiannis   +5 more
wiley   +1 more source

CD123 target validation and preclinical evaluation of ADCC activity of anti-CD123 antibody CSL362 in combination with NKs from AML patients in remission

, 2017
Despite the heterogeneity of acute myeloid leukemia (AML), overexpression of the interleukin-3 receptor-α (CD123) on both the more differentiated leukemic blast and leukemic stem cells (LSCs) provides a therapeutic target for antibody treatment.
L H Xie, M D Minden, S J Busfield, M Biondo, A Arruda, G Vairo, X Yang   +6 more
core   +2 more sources

Polyherbal EMSA ERITIN Promotes Erythroid Lineages and Lymphocyte Migration in Irradiated Mice

Open Life Sciences, 2016
Radiotherapy is commonly used to kill malignant cells, but it can significantly deplete hematopoietic and splenic erythroblasts. Radioprotective agents are therefore very important in clinical radiotherapy.
Ibrahim Mansur, Christina Yuyun Ika, Rifa’i Muhaimin   +2 more
doaj   +1 more source

Breakthrough in Blastic Plasmacytoid Dendritic Cell Neoplasm Cancer Therapy Owing to Precision Targeting of CD123

International Journal of Molecular Sciences
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive hematologic cancer originating from the malignant transformation of plasmacytoid dendritic cell precursors.
S. Zanotta, D. Galati, R. De Filippi, A. Pinto   +3 more
semanticscholar   +1 more source