Results 71 to 80 of about 14,385 (213)

Production and testing of CD123 specific CAR⁺ T cells with CD28 vs. CD137 costimulatory domains.

, 2016
(A) CAR expression in CD123-CD28 (middle) and CD123-CD137 (right) CAR+ and CARneg T cells (left) on day 1and day 35 after electroporation and co-culture on AaPC, Clone 1-CD123.
Tiejuan Mi (332266), Sourindra Maiti (384485), Tamara Laskowski (3070806), Laurence J. N. Cooper (187481), Helen Huls (384486), Richard E. Champlin (187480), Simon Olivares (417497), Harjeet Singh (187475), Drew Deniger (3070812), George McNamara (3070809), Hiroki Torikai (127874), Radhika Thokala (747629)   +11 more
core   +1 more source

Improved Activity against Acute Myeloid Leukemia with Chimeric Antigen Receptor (CAR)-NK-92 Cells Designed to Target CD123

, 2021
Anti-cancer activity can be improved by engineering immune cells to express chimeric antigen receptors (CARs) that recognize tumor-associated antigens. Retroviral vector gene transfer strategies allow stable and durable transgene expression.
Nadine Kattre, Julia Dahlke, Arnold Kloos, Michael A. Morgan, Katharina Zimmermann, Juliette Nowak, Michael Heuser, Maximilian Keisker, Axel Schambach, Marco Bentele, Daniela Lenz, Martin Sauer, Kattre, Nadine, Dahlke, Julia, Morgan, Michael, Kloos, Arnold, Heuser, Michael, Keisker, Maximilian, Schambach, Axel, Zimmermann, Katharina, Nowak, Juliette, Sauer, Martin, Bentele, Marco, Lenz, Daniela   +23 more
core   +1 more source

High CD123 levels enhance proliferation in response to IL-3, but reduce chemotaxis by downregulating CXCR4 expression

Blood Advances, 2017
: High expression of the α chain of the interleukin-3 receptor (IL-3Rα; CD123) is a hallmark of acute myeloid leukemia (AML) leukemic stem cells (LSCs). Elevated CD123 expression is part of the diagnostic immunophenotyping of myeloid leukemia, and higher
Nicole L. Wittwer, Gabriela Brumatti, Ceilidh Marchant, Jarrod J. Sandow, Melanie K. Pudney, Mara Dottore, Richard J. D'Andrea, Angel F. Lopez, Paul G. Ekert, Hayley S. Ramshaw   +9 more
doaj   +1 more source

ICSH Guidance on Bone Marrow Examination and Reporting

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Examination of the bone marrow (BM) remains fundamental to the diagnosis, classification, prognostication, and monitoring of hematolymphoid and other disorders affecting blood cell production. Since publication of the International Council for Standardization in Haematology (ICSH) guideline in 2008, advances in diagnostic technologies, disease
Wendy N. Erber, Alexandar Tzankov, Olga Pozdnyakova, Hiromichi Matsushita, Gina Zini, Leonie Saft, on behalf of the International Council for Standardization in Haematology   +6 more
wiley   +1 more source

Morphological and immunohistochemical (CD4/CD8 T cell and CD123(+) plasmacytoid dendritic cell ratios) comparative analysis of rosacea, discoid lupus erythematosus, and polymorphous light eruption lesions

Indian Journal of Pathology and Microbiology
Background: Rosacea, discoid lupus erythematosus (DLE), and polymorphous light eruption (PLE) can present with overlapping clinical and histopathological features.
Ozge Aydin, Fahriye Kilinc
doaj   +1 more source

Investigation of IgM Monoclonal Paraprotein in Bone Marrow Aspiration: The Role of Immunophenotyping by Flow Cytometry in Selecting Cases for Molecular Testing for the p.MYD88 L265P Point Mutation

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Background Flow cytometry and real‐time quantitative polymerase chain reaction (qRT‐PCR) for MYD88 mutations (MYD88mt) are routinely performed on bone marrow aspirates during the diagnostic evaluation of IgM monoclonal paraproteinemia. The potential predictive value of immunophenotypic findings for molecular results, however, remains to be ...
Georgios Boutsikas, Konstantinos Agiannitopoulos, Elisavet Kouvidi, Myrto Katraki, Athanasios Papatheodorou, Anna Roussou, Nikolaos Paschalidis, Theodoros P. Vassilakopoulos, Ioannis Anagnostopoulos, Dimitra Sasaroli, Aglaia Dimitrakopoulou   +10 more
wiley   +1 more source

Irradiation‐Induced CD62L Shedding in Human Plasmacytoid Dendritic Cells Depends on ADAM17 and p38 MAPK

Immunology, EarlyView.
Human plasmacytoid dendritic cell‐based vaccines efficiently migrate from blood to lymph nodes and prime naive T cells in humanised mice. Irradiation‐induced CD62L shedding, mediated by p38 MAP kinase and ADAM17, is involved in the regulation of PDC migration to secondary lymphoid organs in this model.
Estelle Leplus, Jamila Kacher, Dalil Hannani, Guillaume Vayssiere, Jean‐Paul Molens, Karine Laulanier, Dan Georgess, Véronique Josserand, Philippe Saas, Séverine Planel, Laurence Chaperot, Joel Plumas   +11 more
wiley   +1 more source

Blastic plasmacytoid dendritic cell neoplasia - a rare type of acute leukemia

Romanian Journal of Laboratory Medicine, 2014
Neoplasmul cu celule dendritice plasmocitoide blastice (NCDPB), clasificat recent în grupul leucemiilor acute mieloide este o boală hematologică malignă rară cu evoluţie clinică extrem de agresivă.
Köpeczi Judit Beáta, Benedek Erzsébet, Kakucs Enikő, Tunyogi Aliz, Istrati Monica, Benedek Istvan   +5 more
doaj   +1 more source

Histiocytes: Multifaceted Regulators of Health and Disease

Veterinary Clinical Pathology, EarlyView.
ABSTRACT The mononuclear phagocyte system encompasses macrophages, dendritic cells (DCs), and monocytes. Tissue‐resident macrophages and dendritic cells arise during embryogenesis and are replenished either through self‐renewal or by monocytes during inflammation.
Erika J. Gruber
wiley   +1 more source

Abstract 3818: CD11c+CD123+ human myeloid dendritic cells generated using IL4, IL13 and IL3 show characteristics of myeloid derived suppressor cells

, 2010
Dendritic cells (DCs) are critical for initiation of adaptive immune responses, but they also play important roles in self-tolerance, and in tumor bearing hosts, some DC subsets may contribute to immune evasion.
Hua Zhang, Jeremy V. Edwards, Crystal L. Mackall   +2 more
core   +1 more source