Results 61 to 70 of about 14,385 (213)

Antileukemia Efficacy and Mechanisms of Action of SL-101, a Novel Anti-CD123 Antibody Conjugate, in Acute Myeloid Leukemia. [PDF]

, 2017
Purpose: The persistence of leukemia stem cells (LSC)-containing cells after induction therapy may contribute to minimal residual disease (MRD) and relapse in acute myeloid leukemia (AML).
Kantarjian, Hagop, Zhang, Qi, DiPersio, John, Han, Lina, Nogueras González, Graciela, Pan, Rongqing, Huang, Xuelin, Ravandi, Farhad, Konopleva, Marina, Cavazos, Antonio, Ciurea, Stefan, Cortes, Jorge, Jorgensen, Jeffrey, Ai-Atrash, Gheath, Mu, Hong, Wang, Sa, Shi, Ce, Andreeff, Michael, Zhou, Jin, Rettig, Mike, Brooks, Chris   +20 more
core   +1 more source

Expression of CD123 in B-Acute Lymphoblastic Leukemia as a Predictor of BCR/ABL rearrangement and Disease Relapse

Basic & Clinical Cancer Research
Introduction: CD123 is the alpha chain of the interleukin 3 receptor (IL-3R) and normally expressed on hematopoietic progenitor cells, monocytes, B lymphocytes and endothelial cells.
Birva Nimit Raiya
doaj   +1 more source

A 3D Bioprinted Platform That Maintains the Functional Integrity of Primary AML Cells

Cell Proliferation, EarlyView.
This study presents a 3D bioprinted platform using gelatin‐hyaluronic acid hydrogels to enhance primary AML cell survival and proliferation while preserving stem‐like properties in vitro. By recapitulating in vivo‐like metabolic activity and drug resistance, this system offers a robust tool for preclinical drug screening and personalised therapy ...
Wanling Huang, Bo Deng, Nini Guo, Yiyi Ding, Zhangjingwen Xu, Yiwen Lu, Yue Ma, Qian Ren, Nan Wang, Pengyu Huang, Xiaotong Ma   +10 more
wiley   +1 more source

Human Bronchial Epithelial Cells Induce CD141/CD123/DC-SIGN/FLT3 Monocytes That Promote Allogeneic Th17 Differentiation [PDF]

, 2017
Little is known about monocyte differentiation in the lung mucosal environment and about how the epithelium shapes monocyte function. We studied the role of the soluble component of bronchial epithelial cells (BECs) obtained under basal culture ...
Anne Wilson, Katrin Hostettler, Cesson, Valerie, Valerie Cesson, Aubert, John David, Carolina Obregon, Laurent P. Nicod, Lazor, Romain, Blank, Fabian, Gazdhar, Amiq, John David Aubert, Amiq Gazdhar, Obregon, Carolina, Nicod, Laurent P, Romain Lazor, Spertini, Francois, Fabian Blank, Hostettler, Katrin, Alban Lovis, Wilson, Anne, Lovis, Alban, Francois Spertini, Nicod LP, Gazdhar A, Gazdhar, A., Aubert, J.D., Spertini F, Lovis A, Lazor R, Obregon C, Cesson, V., Spertini, F., Lazor, R., Hostettler K, Blank, F., Nicod, L.P., Aubert JD, Wilson, A., Hostettler, K., Blank F, Obregon, C., Wilson A, Lovis, A., Cesson V   +43 more
core   +2 more sources

Novel CD123 polyaptamer hydrogel edited by Cas9/sgRNA for AML-targeted therapy

Drug Delivery, 2021
CD123 targeting molecules have been widely applied in acute myelocytic leukemia (AML) therapeutics. Although antibodies have been more widely used as targeting molecules, aptamer have unique advantages for CD123 targeting therapy.
Haibin Wu, Liyu Zhang, Zeen Zhu, Chenxi Ding, Shengquan Chen, Ruiping Liu, Huafeng Fan, Yang Chen, Hui Li   +8 more
doaj   +1 more source

Targeting Leukemias by CD123 Specific Chimeric Antigen Receptor [PDF]

Blood, 2011
Abstract Abstract 1908 Chimeric antigen receptors (CARs) are employed to genetically modify T cells to redirect their specificity to target antigens on tumor cells. Typically a second generation CAR is derived by fusing an extracellular domain derived from the scFv of monoclonal antibody (CAR) specific to targeted antigen ...
Thokala, R., Olivares, S., Singh, H., Champlin, R.E., Cooper, L.J.N.   +4 more
openaire   +1 more source

Elevated IL‐4 and IL‐13 Expression in Hailey‐Hailey Disease: Evidence for Th2‐Mediated Pathogenesis and Targeted Treatment

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT Background Hailey‐Hailey disease (HHD) is a rare autosomal dominant blistering disorder caused by mutations in the ATP2C1 gene, which impair keratinocyte adhesion through disrupted calcium signaling. While traditionally considered a structural defect, recent studies suggest that Th2‐mediated inflammation may exacerbate disease pathology ...
Simonetta I. Gaumond, Victoria Soto, Beatriz Abdo Abujamra, Franco Rongioletti, John A. McGrath, Ivan Jozic, Paolo Romanelli   +6 more
wiley   +1 more source

Utility of IL‐18 Immunohistochemistry in Distinguishing Dermatomyositis and Lupus Erythematosus in Skin Biopsies

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT Background Distinction of dermatomyositis (DM) and cutaneous lupus erythematosus (LE) in skin biopsies is often difficult due to significant histopathologic overlap. Prior transcriptional analysis has identified upregulation of IL‐18 in DM compared with LE.
Steven M. Hrycaj, Joseph S. Durgin, Johann E. Gudjonsson, J. Michelle Kahlenberg, Gaidaa R. Majari, Carole Bitar, Catherine G. Chung, Rosalynn M. Nazarian, May P. Chan   +8 more
wiley   +1 more source

Chimeric antigen receptors against CD33/CD123 antigens efficiently target primary acute myeloid leukemia cells in vivo

, 2014
As significant numbers of acute myeloid leukemia (AML) patients are still refractory to conventional therapies or experience relapse, immunotherapy using T cells expressing chimeric antigen receptors (CARs) might represent a valid treatment option.
K Rouault-Pierre, Bonnet, D., I Pizzitola, Anjos-Afonso, Fernando, Biagi, E., A Biondi, Pizzitola, I., O Spinelli, F Lassailly, F Anjos-Afonso, Tettamanti, S., Spinelli, O., S Tettamanti, Rouault-Pierre, K., Lassailly, F., E Biagi, Biondi, A., D Bonnet   +17 more
core   +1 more source

Cutaneous involvement by myeloid leukaemias: challenging cases with important implications

Histopathology, EarlyView.
Myeloid leukaemias and precursors involving the skin are often challenging to diagnose with varied and overlapping clinical and histopathologic features. Nonetheless, they are critical for pathologists to recognize and accurately classify. This review discusses the clinical, histopathological and genetic features of myelodysplasia cutis (A) and ...
Alexandra C. Hristov
wiley   +1 more source