Results 51 to 60 of about 4,963 (151)

Identification of a Novel De Novo Heterozygous SEC61A1 Variant in a Patient With Severe Congenital Neutropenia

Molecular Genetics &Genomic Medicine, Volume 14, Issue 5, May 2026.
Severe congenital neutropenia can be caused by rare SEC61A1 variants. We report a child with SCN showing granulocytic maturation arrest and abnormal immunophenotype, carrying a novel de novo SEC61A1 p.Trp379Arg variant, expanding the phenotypic and genetic spectrum of SEC61A1‐associated SCN.
Zixuan Wang, Hui Jing, Yuhan Chen, Ling Zhong, Jiyun Yang   +4 more
wiley   +1 more source

Brain Pericytes and Wnt/β‐Catenin Signaling Induce Functional Blood–Brain Barrier Phenotype in Human iPSC‐Derived Model

Small Methods, Volume 10, Issue 10, 22 May 2026.
This study shows that human iPSC‐derived endothelial cells acquire a functional blood–brain barrier phenotype when co‐cultured with brain pericytes and stimulated with CHIR‐99021, a Wnt/β‐catenin activator. This model recapitulates key barrier properties, inflammatory responses, and transcriptomic features of the native human BBB, offering new ...
Henrique Nogueira Pinto, Nine R. Kok, Philipp C. Hauger, Manon Karsten‐van Diepen, Michael de Kok, Nanne J. Paauw, Susanne M. A. van der Pol, Joline P. Nugteren‐Boogaard, Peter L. Hordijk, Stephanie D. Beekhuis‐Hoekstra, Susan Gibbs, Nienke M. de Wit, Helga E. de Vries   +12 more
wiley   +1 more source

Immunophenotypic study of acute leukemia by flow cytometry at BPKMCH.

Journal of Pathology of Nepal, 2013
Background: Immunophenotyping of acute leukemia is one of the most important clinical applications of fl ow cytometry. The aim of this study was to determine the immunophenotyping profi le of acute leukemia, by means of a fl ow cytometric method, using ...
S Shrestha, J Shrestha, CB Pun, T Pathak, S Bastola, R Bhatta   +5 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, Volume 20, Issue 4, Page 947-961, April 2026.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

High-throughput immunophenotypic characterization of bone marrow- and cord blood-derived mesenchymal stromal cells reveals common and differentially expressed markers: identification of angiotensin-converting enzyme (CD143) as a marker differentially expressed between adult and perinatal tissue sources

Stem Cell Research & Therapy, 2018
Background Mesenchymal stromal cells (MSC) are a heterogeneous population of multipotent progenitors used in the clinic because of their immunomodulatory properties and their ability to differentiate into multiple mesodermal lineages.
Eliana Amati, Omar Perbellini, Gianluca Rotta, Martina Bernardi, Katia Chieregato, Sabrina Sella, Francesco Rodeghiero, Marco Ruggeri, Giuseppe Astori   +8 more
doaj   +1 more source

DSG2+ Cancer Stem Cells Co‐Located With FAP+ Myofibroblasts in the Tumor Boundary That Determines the Efficacy of Immunotherapy in Non‐Small Cell Lung Cancer

Advanced Science, Volume 13, Issue 23, 23 April 2026.
Cancer stem cells (CSCs) in non‐small cell lung cancer display pronounced plasticity and spatial heterogeneity. By integrating single‐cell and spatial transcriptomics, this study defines a DSG2‐associated CSC program and reveals a tumor‐margin niche formed with FAP+ myofibroblasts.
Guangyu Fan, Le Tang, Tongji Xie, Mengwei Yang, Lin Li, Sheng Yang, Puyuan Xing, Xiaohong Han, Yuankai Shi   +8 more
wiley   +1 more source

Is Flow Cytometric Immunophenotyping Useful for Predicting Acute Myeloid Leukemia Prognosis?

İstanbul Medical Journal, 2017
Introduction: Acute myeloid leukemia (AML) is an aggressive clonal myeloid neoplasm that causes the accumulation of myeloblasts in blood and bone marrow.
Hava Üsküdar Teke, Nur Oğuz Davutoğlu, Eren Gündüz, Neslihan Andıç, Cengiz Bal, Beyhan Durak Aras   +5 more
doaj   +1 more source

Aislamiento y caracterización de células “stem” mesenquimales de médula ósea humana según criterios de la Sociedad Internacional de Terapia Celular

Universitas Scientiarum, 2010
Isolation and characterization of mesenchymal stem cells from human bone marrow according to the criteria of the InternationalSociety for Cellular Therapy.
Jose Alejandro Aristizabal-Castellanos, María Fernanda Fuentes-Lacouture, Vivian Marcela Rodríguez-Pardo   +2 more
doaj  

SET-NUP214 Fusion Gene Involved Early T-Cell Precursor Acute Lymphoblastic Leukemia in Adult with B Marker Expression

International Journal of General Medicine, 2021
Xiaoying Xu,1 Qiongli Zhai,1 Hao Jin,2 Yong Yu,3 Dongmei Han,2 Huilai Zhang,4 Kai Fu,5 Bin Meng1 1Department of Pathology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer ...
Xu X, Zhai Q, Jin H, Yu Y, Han D, Zhang H, Fu K, Meng B   +7 more
doaj  

Validación del ultramicrométodo inmunocitoquímico (UMICIQ) para el inmunofenotipaje de la leucemia linfoide aguda pediátrica Validation of immunocytochemical ultramicromethod (UMICIQ) for immunophenotyping of pediatric acute lymphoid leukemia

Revista Cubana de Hematología, Inmunología y Hemoterapia, 2012
El objetivo de este trabajo fue comparar el ultramicrométodo inmunocitoquímico (UMICIQ) con la citometría de flujo (CMF), para el diagnóstico inmunológico de la leucemia linfoide aguda (LLA) pediátrica. Se procesó la médula ósea de 30 pacientes con LLA y
Vianed Marsán-Suárez, Lázaro del Valle-Pérez, Berta B Socarrás-Ferrer, Miriam Sánchez-Segura, Consuelo Macías-Abraham, Zaima Mazorra-Hererra, Rosa M Lam-Díaz   +6 more
doaj