Results 31 to 40 of about 188,070 (188)

Ezetimib influences the expression of raft-associated antigens in human monocytes

, 2006
Aminopeptidase N (CD13) was recently identified as a molecular target of the cholesterol absorption inhibitor Ezetimib. Regarding that CD13 is expressed in lipid rafts of monocytic cells, we have investigated whether Ezetimib influences raft function in ...
Orsó, Evelyn, Bandulik, Sascha, Kramer, Werner, Wolf, Zsuzsanna, Schmitz, Gerd, Werner, Tobias   +5 more
core   +1 more source

CD13 Inhibition Enhances Cytotoxic Effect of Chemotherapy Agents [PDF]

, 2018
Multidrug resistance (MDR) of hepatocellular carcinoma is a serious problem. Although CD13 is a biomarker in human liver cancer stem cells, the relationship between CD13 and MDR remains uncertain. This study uses liver cancer cell model to understand the
Zhaolin Zhang, Shujuan Liang, Hui Ma, Weiguo Song, Yongxue Huang, Lihong Shi, Meihua Qu, Xuejuan Wang, Chunyan Fang, Hongan Zhang, Xuejian Wang, Jian Zhang, Zhiqin Gao, Huina Wu   +13 more
core   +1 more source

ACUTE LEUKEMIA OF MIXED B, T AND MYELOID PHENOTYPE WITH COMPLEX KARYOTYPE: TREATABLE DISEASE OR DEATH SENTENCE?

Hematology, Transfusion and Cell Therapy, 2023
The case was attended by our team at Santa Casa de São José dos Campos, a teaching hospital with Accreditation Level 3 from National Accreditation Organization, classified as structuring hospital by the government of the State of São Paulo, which serves ...
DTK Obikawa, LA Vianna, AAM Zung, ES Rosa, F Callera   +4 more
doaj   +1 more source

Absence of prognostic impact of CD13 and/or CD33 antigen expression in adult acute lymphoblastic leukemia. Results of the GIMEMA ALL 0496 trial

Haematologica, 2007
The prognostic value of myeloid antigen (MyAg) expression in adult acute lymphoblastic leukemia (ALL) is still controversial. The aim of this study was to correlate the expression of MyAg with clinical, hematologic and biological parameters, and to analyze the impact on response to treatment and prognosis in a large series of adult ALL uniformly ...
A. Vitale, GUARINI, Anna, C. Ariola, MELONI, Giovanna, O. Perbellini, M. Pizzuti, C. D. Gregoris, V. Mettivier, A. Pastorini, G. Pizzolo, VIGNETTI, Marco, MANDELLI, Franco, FOA, Roberto   +12 more
openaire   +5 more sources

Neutralization of human cytomegalovirus by human CD13-specific antibodies

, 1996
The mechanisms of inhibition of cytomegalovirus (CMV) infection by human CD13 (aminopepti-dase N)-specific antibodies were studied. These antibodies protect CD13-negative and-positive cells from CMV infection only if incubated with the virus inoculum ...
Erna Moller, K.-O. Hedlund, E. Moller, Moller, E, Terrence D. Giugni, Robert M. Bautista, D. J. Ham, Soderberg, C, Bautista, RM, R. M. Bautista, C. Soderberg, Debby J. Ham, Hedlund, KO, Zaia, JA, Cecilia Soderberg, Ham, DJ, Kjell-olof Hedlund, John A. Zaia, J. A. Zaia, T. D. Giugni, Giugni, TD   +20 more
core   +1 more source

A Retinal Matrix Stiffening Model Reveals FAK‐Dependent Mechanotransduction in Pericytes Underlies Vascular Destabilization

Advanced Materials, EarlyView.
In this study, we show that retinal matrix stiffness is increased in diabetic mice. Using engineered human vascular models with controlled matrix stiffness, we demonstrate that stiffening activates focal adhesion kinase (FAK) signaling in pericytes, suppresses Notch signaling, and disrupts vascular morphology.
Emily Warren, Alex Wu, Lucas Ramirez, Yaqing Huang, Connor Amelung, Sophia Saxonhouse, Sharon Gerecht   +6 more
wiley   +1 more source

Cannabidiol modulates the immunophenotype and inhibits the activation of the inflammasome in human gingival mesenchymal stem cells

Frontiers in Physiology, 2016
Human Gingival Mesenchymal Stem Cells (hGMSC) are multipotential cells that can expand and differentiate in culture under specific and standardized conditions.
Rosaliana Libro, Domenico Scionti, Francesca Diomede, Marco Marchisio, Gianpaolo Grassi, Federica Pollastro, Adriano Piattelli, Placido Bramanti, EMANUELA MAZZON, Oriana Trubiani   +9 more
doaj   +1 more source

Acute leukemia of childhood: A single institution's experience [PDF]

Archives of Biological Sciences, 2005
The aim of this study was to investigate distribution of immunophenotypic and cytogenetic features of childhood acute leukemia (AL) in the cohort of 239 newly diagnosed patients registered at the leading pediatric oncohematology center in the country ...
Slavković Bojana, Guć-Šćekić Marija, Bunjevački Gordana, Đuričić S., Krstić Aleksandra, Mićić D., Vujić Dragana, Kuzmanović M., Rašović-Gvozdenović Nada   +8 more
doaj   +1 more source

A practical difference from the normal approach to evaluate natural killer (NK) cells and NK cell neoplasms by flow cytometry

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Natural killer (NK) cell neoplasms span indolent to highly aggressive entities, and flow cytometric immunophenotyping is central to their detection and classification. However, distinguishing reactive from neoplastic NK cell expansions can be challenging because NK cells lack somatically recombined antigen receptors, and reactive states may ...
Aaron J. Wilk, Afshin Shameli, Erik Ames, Jonathan R. Fromm, Bartosz Grzywacz, Min Shi, Sindhu Cherian, Jean Oak   +7 more
wiley   +1 more source

CD13 is a novel mediator of monocytic/endothelial cell adhesion

, 2008
Udgivelsesdato: 2008-AugDuring inflammation, cell surface adhesion molecules guide the adhesion and migration of circulating leukocytes across the endothelial cells lining the blood vessels to access the site of injury. The transmembrane molecule CD13 is
Catherine O’Conor, Holmes, Kathryn V, Kathryn V Holmes, Rodriguez-Pinto, Daniel, Shapiro, Linda H, Grant, Christina L, Paola Mina-Osorio, Christina L Grant, Daniel Rodriguez-Pinto, Vogel, Lotte K., Beata Winnicka, Enrique Ortega, O'Conor, Catherine, Ortega, Enrique, Linda H Shapiro, Lotte K Vogel, Winnicka, Beata, Mina-Osorio, Paola   +17 more
core   +1 more source