Results 21 to 30 of about 188,070 (188)

Efficient targeting of CD13 on cancer cells by the immunotoxin scFv13-ETA ' and the bispecific scFv [13xds16]

, 2022
S.2159-2170Treatment of cancer using standard chemotherapy still offers a poor prognosis combined with severe side effects. Novel antibody-based therapies have been shown to overcome low efficiency and lack of selectivity by targeting cancer-associated ...
Gresch, G., Fischer, R., Stein, C., Woitok, M., Fendel, R., Grieger, E., Niesen, J., Barth, S.   +7 more
core   +1 more source

Characteristics of myeloid differentiation and maturation pathway derived from human hematopoietic stem cells exposed to different linear energy transfer radiation types. [PDF]

PLoS ONE, 2013
Exposure of hematopoietic stem/progenitor cells (HSPCs) to ionizing radiation causes a marked suppression of mature functional blood cell production in a linear energy transfer (LET)- and/or dose-dependent manner.
Satoru Monzen, Hironori Yoshino, Kiyomi Kasai-Eguchi, Ikuo Kashiwakura   +3 more
doaj   +1 more source

MULTIPARAMETRIC FLOW CYTOMETRY REFINES RISK STRATIFICATION IN NEWLY DIAGNOSED MULTIPLE MYELOMA PATIENTS

Mediterranean Journal of Hematology and Infectious Diseases, 2023
Multiple myeloma (MM) is a heterogeneous malignancy characterized by the proliferation of abnormal plasma cells in the bone marrow. Multiparametric flow cytometry (MFC) plays a role in the work-up of the disease in view of the aberrant expression of ...
Francesca Fazio, Gianfranco Lapietra, Maria Zaira Limongi, Stefania Intoppa, Maria Laura Milani, Alfonso Piciocchi, Maurizio Martelli, Anna Guarini, Robin Foà, Maria Stefania De Propris, Maria Teresa Petrucci   +10 more
doaj   +1 more source

Identification of APN/CD13 as the target antigen of FU3, a human monoclonal antibody that recognizes malignant fibrous histiocytoma

International Journal of Oncology, 2013
Malignant fibrous histiocytoma (MFH), a high-grade, undifferentiated sarcoma, is highly aggressive, resistant to radiochemotherapy and associated with poor prognosis. There are no specific immunohistochemical markers for its diagnosis. The MFH cell line SFT7913 served as and immunogen for the generation of the FU3 monoclonal antibody in our laboratory.
Mikiko, Aoki, Kazuki, Nabeshima, Hiroyuki, Hayashi, Makoto, Hamasaki, Hiroshi, Iwasaki   +4 more
openaire   +3 more sources

The immunoregulatory abilities of polymorphonuclear neutrophils in the course of multiple sclerosis

Mediators of Inflammation, 1998
The polymorphonuclear neutrophils (PMN) possess sufficient potential to affect both immune response and inflammation, however it has not been yet described in the course of multiple sclerosis (MS).
J. Ziaber, J. PaSnik, Z. Baj, L. Pokoca, H. Chmielewski, H. Tchórzewski   +5 more
doaj   +1 more source

1,25-Dihydroxyvitamin D3 Stimulates Phagocytosis but Suppresses HLA-DR and CD13 Antigen Expression in Human Mononuclear Phagocytes

Experimental Biology and Medicine, 1996
This study investigated the regulatory activity of 1,25-dihydroxyvitamin D3 (1,25-[OH]2D3) on phagocytic cells obtained from normal human peripheral blood. Flow cytometric analysis enabled identification of two discrete populations of cells, one predominantly monocytes ("monocyte" gate) and one containing primarily lymphoid and other cell types ...
N, Tokuda, R B, Levy
openaire   +2 more sources

CD13 facilitates immune cell migration and aggravates acute injury but promotes chronic post-stroke recovery [PDF]

, 2023
Introduction Acute stroke leads to the activation of myeloid cells. These cells express adhesion molecules and transmigrate to the brain, thereby aggravating injury.
Pandya, Gargee, Justin N. Nguyen, Marrelli, Sean P, Linda Shapiro, Ali, Uzma, Chunfeng Tan, Sean P. Marrelli, Eric C. Mohan, Anjali Chauhan, Tan, Chunfeng, Shapiro, Linda, Mohan, Eric C, Uzma Ali, Gargee Pandya, Nguyen, Justin N, Chauhan, Anjali, Julia K. Kofler, Kofler, Julia K   +17 more
core   +1 more source

Diagnostic Utility of Immunophenotyping by Flow Cytometry for Diagnosis and Classification of Acute Leukemias in Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia

Indonesian Journal of Cancer, 2021
Background: Immunophenotypic characterization of acute leukemia is an important clinical application of flow cytometry and has become a powerful tool contributing to proper diagnosis and classification.
Metasebia Tegegen, Fatuma Hassen, Abdulaziz Abubeker, Fissehatsion Tadesse, Daniel Hailu, Ashenafi Alemu, Aster Tsageye, Rawleigh Howe, Amha Gebremedhin   +8 more
doaj   +1 more source

Myeloid antigens in childhood lymphoblastic leukemia:clinical data point to regulation of CD66c distinct from other myeloid antigens

BMC Cancer, 2005
Background Aberrant expression of myeloid antigens (MyAgs) on acute lymphoblastic leukemia (ALL) cells is a well-documented phenomenon, although its regulating mechanisms are unclear. MyAgs in ALL are interpreted e.g.
Madzo Jozef, Mejstrikova Ester, Vaskova Martina, Kalina Tomas, Trka Jan, Stary Jan, Hrusak Ondrej   +6 more
doaj   +1 more source

Expression of CD13 and CD26 on extracellular vesicles in canine seminal plasma: preliminary results [PDF]

Canine seminal plasma is a complex fluid containing proteins, peptides, enzymes, hormones as well as extracellular vesicles that are involved in many physiological and pathological processes including reproduction.
Talesa, Vincenzo Nicola, Troisi, Alessandro, Fallarino, Francesca, Martìnez Barbitta, Marcelo, Pieramati, Camillo, Di Michele, Alessandro, Orlandi, Riccardo, Schrank, Magdalena, Verstegen, John P., Pastore, Sara, Polisca, Angela, Bellezza, Ilaria, Verstegen, John P   +12 more
core   +1 more source