Results 91 to 100 of about 188,530 (334)

Research note: Turkey (Meleagris gallopavo) semen CD14+ macrophages – management, key features, and classification – a pilot study with optimized protocols

Poultry Science
Semen macrophages (Mф) play a role in mediating innate immune responses and supporting adaptive immunity within the male reproductive tract. Knowledge about the semen Mф in avian species remains limited.
Ewa M. Drzewiecka, Anna Szóstek-Mioduchowska, Joanna Wiśniewska, Ewa Liszewska, Mariola Słowińska   +4 more
doaj   +1 more source

CD14+CD16− monocytes are the main precursors of osteoclasts in rheumatoid arthritis via expressing Tyro3TK

Arthritis Research & Therapy, 2020
Background Monocytes as precursors of osteoclasts in rheumatoid arthritis (RA) are well demonstrated, while monocyte subsets in osteoclast formation are still controversial.
Jimeng Xue, Liling Xu, Huaqun Zhu, Mingxin Bai, Xin Li, Zhen Zhao, Hua Zhong, Gong Cheng, Xue Li, Fanlei Hu, Yin Su   +10 more
doaj   +1 more source

Expression analysis of HLA-E and NKG2A and NKG2C receptors points at a role for natural killer function in ankylosing spondylitis [PDF]

, 2018
Background. Ankylosing Spondylitis (AS) is a complex chronic inflammatory disease strongly associated with the majority of HLA-B27 alleles. HLA-E are non-classical MHC class I molecules that specifically interact with the natural killer receptors NKG2A ...
Angioni, Mm, Cauli, A, Congia, M, Dessole, G, Fiorillo, Mt, Floris, A, Mascia, E, Mathieu, A., Paladini, F, Piga, M, Pinna, S, Sorrentino, R, Tedeschi, V   +12 more
core   +1 more source

Immune Predictors of Radiotherapy Outcomes in Cervical Cancer

Advanced Science, EarlyView.
This study reveals dynamic immune remodeling in cervical cancer following radiotherapy. Single‐cell analysis identifies the C3/C3AR1 axis as a central mediator of epithelial–myeloid crosstalk, whose inhibition reduces treatment efficacy in mice. Guided by these insights, the eight‐feature machine‐learning model: Cervical Cancer Radiotherapy Immune ...
Linghao Wang, Jie Zhu, Zequn Ding, Zhiyuan Xie, Xingchen Liu, Feihong Zhang, Xiaojun Liu, Yan Zhang, Haiyan Chen   +8 more
wiley   +1 more source

The CD14 (−159 C/T) SNP is associated with sCD14 levels and allergic asthma, but not with CD14 expression on monocytes

Scientific Reports, 2018
LPS-ligation to CD14/TLR-4 on monocytes/macrophages triggers the production of IL-12-family cytokines. IL12/18 promote TH1-differentiation, counteracting the TH2-driven asthma.
J. J. Nieto-Fontarigo, F. J. Salgado, M. E. San-José, M. J. Cruz, A. Casas-Fernández, M. J. Gómez-Conde, L. Valdés-Cuadrado, M. Á. García-González, P. Arias, M. Nogueira, F. J. González-Barcala   +10 more
doaj   +1 more source

Exosomal αvβ6 integrin is required for monocyte M2 polarization in prostate cancer [PDF]

, 2018
Therapeutic approaches aimed at curing prostate cancer are only partially successful given the occurrence of highly metastatic resistant phenotypes that frequently develop in response to therapies.
Altieri, Dario C., Bowler, Nicholas, Craig Hooper, D., Dutta, Anindita, Ertel, Adam, Fedele, Carmine, Forsberg, Flemming, Fortina, Paolo, Gabrilovich, Dmitry I., Harshyne, Larry A., Kean, Rhonda B., Kelly, William K., Kossenkov, Andrew V., Krishn, Shiv Ram, Kurtoglu, Senem, Languino, Lucia R., Liu, Qin, Lu, Huimin, Speicher, David W., Stanczak, Maria, Tang, Hsin-Yao, Wang, Kerith, Weinreb, Paul H., Yu, Lei   +23 more
core   +1 more source

Human Atlas of Tooth Decay Progression: Identification of Cellular Mechanisms Driving the Switch from Dental Pulp Repair Toward Irreversible Pulpitis

Advanced Science, EarlyView.
Tooth decay progression transforms the dental pulp response from repair to fibrosis. At early stages, stromal cells reprogram to repair the extra cellular matrix (ECM), blood vessels, and nerves, remodel and grow, keeping repair possible. In advanced decay, hypoxia, and vessel regression, in complement with an immune switch, fuel nerve degeneration and
Hoang Thai Ha, Sofya Kosmynina, Amandine Verocq, Keremsah Ozen, Ines Tekia, Hugo Bussy, Marie Ramirez, Dima Sabbah, Chloe Goemans, Valerie Vandenbempt, Esteban N. Gurzov, Sumeet Pal Singh, Nicolas Baeyens   +12 more
wiley   +1 more source

Toll-like receptor-mediated signaling cascade as a regulator of the inflammation network during alcoholic liver disease [PDF]

, 2014
Chronic abuse of alcohol leads to various histological abnormalities in the liver. These are conditions collectively known as alcoholic liver disease (ALD). Currently, ALD is considered to be one of the major causes of death worldwide.
Alisi, A., Ceccarelli, S, Nobili, V
core   +1 more source

Targeting Itga8 Mitigates Neurogenic Bladder Fibrosis Driven by Trem2⁺ Macrophage‐Derived Fn1 via FAK/RhoA/ROCK Signaling

Advanced Science, EarlyView.
Normal bladders exhibit quiescent fibroblasts/macrophages, whereas neurogenic bladders show acute‐phase Itga8⁺ fibroblast expansion driven by Trem2⁺ macrophage‐secreted Fn1, which activates FAK/RhoA/ROCK signaling, promotes cytoskeletal remodeling, and upregulates pro‐fibrotic genes.
Jiaxin Wang, Siyuan Wang, Lida Ren, Xinqi Liu, Lei Zhang, Peng Hu, Wenchao Xu, Shuaixiang Zheng, Jihong Liu, Qing Ling   +9 more
wiley   +1 more source

Macrophage‐derived MLKL in alcohol‐associated liver disease: Regulation of phagocytosis

Hepatology, EarlyView., 2022
EtOH causes leaky gut allowing bacteria and PAMPs into the liver, resulting in hepatic inflammation and injury. We demonstrate that LPS induces STAT1‐mediated expression and phosphorylation of MLKL in macrophages and identify a novel function that myeloid MLKL translocates to phagosomes and lysosomes and regulates phagocytosis, which contributes to the
Xiaoqin Wu, Xiude Fan, Megan R. McMullen, Tatsunori Miyata, Adam Kim, Vai Pathak, Jianguo Wu, Le Z. Day, Josiah E. Hardesty, Nicole Welch, Jaividhya Dasarathy, Daniela S. Allende, Arthur J. McCullough, Jon M. Jacobs, Daniel M. Rotroff, Srinivasan Dasarathy, Laura E. Nagy   +16 more
wiley   +1 more source