Results 81 to 90 of about 7,732 (197)

Costimulatory Molecule DNAM-1 Is Essential for Optimal Differentiation of Memory Natural Killer Cells during Mouse Cytomegalovirus Infection [PDF]

, 2014
Recent studies demonstrate that natural killer (NK) cells have adaptive immune features. Here, we investigated the role of the costimulatory molecule DNAM-1 in the differentiation of NK cells in a mouse model of cytomegalovirus (MCMV) infection. Antibody
Fu Guo, Gascoigne Nicholas R.J., Kanaya Minoru, Lanier Lewis L., Nabekura Tsukasa, Shibuya Akira, 渋谷 彰   +6 more
core   +1 more source

Ligand‐specific tuning of CLEC10A signalling strength and dendritic cell responses through engagement of different GalNAc‐containing glycan structures

The FEBS Journal, EarlyView.
The authors investigated the effects of various glycan ligands for CLEC10A, a lectin receptor expressed on dendritic cells (DCs). Monocyte‐derived DCs were stimulated with glycan‐conjugated dendrimers in combination with the TLR1/2 ligand Pam3CysK4, and responses were investigated at the mRNA and protein level.
Nadia L. van der Meijs, Remi Hatinguais, Mike de Kok, R. J. Eveline Li, Tesfay M. Godefa, Victor L. J. L. Thijssen, Yvette van Kooyk, Sandra J. van Vliet   +7 more
wiley   +1 more source

CD155/PVR plays a key role in cell motility during tumor cell invasion and migration

BMC Cancer, 2004
Background Invasion is an important early step of cancer metastasis that is not well understood. Developing therapeutics to limit metastasis requires the identification and validation of candidate proteins necessary for invasion and migration. Methods We
Roy Jennifer E, Simeone Marina, Torella Claudia, Zehetmeier Carol, Stewart Jean K, Eustace Brenda K, Sloan Kevin E, Unger Christine, Louis David N, Ilag Leodevico L, Jay Daniel G   +10 more
doaj   +1 more source

Comparative Study of Immune Regulatory Properties of Stem Cells Derived from Different Tissues. [PDF]

, 2013
International audience: Allogeneic stem cell (SC)-based therapy is a promising tool for the treatment of a range of human degenerative and inflammatory diseases.
Anversa, Piero, Bassi, Giulio, Bifari, Francesco, De Coppi, Paolo, Decimo, Ilaria, Di Trapani, Mariano, Fontana, Emanuela, Fumagalli, Guido, Féron, Francois, Giacomello, Luca, Krampera, Mauro, Menard, Cedric, Pacelli, Luciano, Pozzobon, Michela, Ricciardi, Mario, Tarte, Karin   +15 more
core   +4 more sources

scRNA‐Seq reveals anti‐lymphoma immune responses in mogamulizumab‐associated skin eruptions

Journal of the European Academy of Dermatology and Venereology, EarlyView.
CCR4 was expressed in malignant clones and regulatory T cells in untreated CTCL, that were decreased in MAR. Malignant clones in MAR showed a silenced phenotype with decreases in central memory markers SELL and CCR7, and GTP‐binding member GIMAP7 and upregulation of MMP2 inhibitor TIMP2 and tumour suppressor gene RUNX3.
Shannon Meledathu, Agata Kurowski, Malini P. Naidu, Jonas Adalsteinsson, Shane A. Meehan, Natalia Alkon, Lauren R. Port, Sumanth Chennareddy, Emry R. Cohenour, Grace Christensen, Jonah Shulman, Nicholas Gulati, Constanze Jonak, Patrick M. Brunner   +13 more
wiley   +1 more source

Prognostic significance of CD155 mRNA expression in soft tissue sarcomas

Oncology Letters, 2013
CD155 was initially identified as a receptor for poliovirus. Several studies have demonstrated that CD155 overexpression in cancer cells is significant in their migration, invasion, proliferation and metastasis. The objective of the present study was to investigate the correlation between CD155 expression and the clinical aggressiveness of soft tissue ...
ATSUMI, SATORU, MATSUMINE, AKIHIKO, TOYODA, HIDEMI, NIIMI, RUI, IINO, TAKAHIRO, SUDO, AKIHIRO   +5 more
openaire   +3 more sources

Impact of immune checkpoint gene CD155 Ala67Thr and CD226 Gly307Ser polymorphisms on small cell lung cancer clinical outcome

Scientific Reports, 2021
This study was conducted to investigate the impact of genetic variants of immune checkpoint genes on the treatment outcome in small cell lung cancer (SCLC). In the present study, 261 platinum doublet-treated SCLC patients were enrolled.
Jang Hyuck Lee, Seung Soo Yoo, Mi Jeong Hong, Jin Eun Choi, Soyoun Kim, Hyo-Gyoung Kang, Sook Kyung Do, Ji Hyun Kim, Sun Ah Baek, Won Kee Lee, Jae Do Yoo, Sun Ha Choi, Yong Hoon Lee, Hyewon Seo, Jaehee Lee, Shin Yup Lee, Seung Ick Cha, Chang Ho Kim, Jae Yong Park   +18 more
doaj   +1 more source

Immune activation by combination human lymphokine-activated killer and dendritic cell therapy. [PDF]

, 2011
BACKGROUND: Optimal cellular immunotherapy for cancer should ideally harness both the innate and adaptive arms of the immune response. Lymphokine-activated killer cells (LAKs) can trigger early innate killing of tumour targets, whereas long-term adaptive-
Jennings, VA, Melcher, AA, Scott, KJ, West, EJ   +3 more
core   +1 more source

T‐cell exhaustion from a multiomics perspective: Differentiation mechanisms and regulatory networks in the journey from progenitor‐Exhausted T cells to terminally exhausted T cells

Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.
(1) Core Process: Persistent antigen, from TDLNs to TME, drives Tpex → Tex‐int → Tex‐term differentiation. (2) Multiomics Regulation: This fate transition is orchestrated by a co‐ordinated, multi‐layered molecular network. (3) Functional Outcome: Dysregulated signalling and surging co‐inhibitory receptors lock in proliferative arrest and functional ...
Tong Zhu, Xiaoyu Teng, Qinlian Jiao, Yidan Ren, Yunshan Wang, Maoxiao Feng   +5 more
wiley   +1 more source

MicroRNA-326 Negatively Regulates CD155 Expression in Lung Adenocarcinoma

, 2022
Abstract Treatment with immune checkpoint inhibitors induces a durable response in some patients with non–small cell lung cancer, but eventually gives rise to drug resistance. Upregulation of CD155 expression is implicated as one mechanism of resistance to PD-1/PD-L1 inhibitors, and it is therefore important to characterize the mechanisms ...
Takayuki Nakanishi, Yasuto Yoneshima, Koji Okamura, Mikiko Hashisako, Naoki Haratake, Keiichi Ota, Eiji Iwama, Tomoyoshi Takenaka, Kentaro Tanaka, Tomoharu Yoshizumi, Yoshinao Oda, Isamu Okamoto   +11 more
openaire   +1 more source