Results 51 to 60 of about 57,461 (287)

Prognostic Implications of Tumor-Associated Macrophages in Oral Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis

Journal of Orofacial Sciences
Introduction: Tumor-associated macrophages (TAMs) are the major cellular component in the tumor microenvironment of oral squamous cell carcinoma (OSCC). Several studies have been put forward to assess the role of TAMs in the prognostication of OSCC.
Surya Surendran L, Anna Palliath Joseph, Varun B Raghavan Pillai, Vinej Somaraj, Sunjith Sudhakar, Amitha Mohan   +5 more
doaj   +1 more source

Alterations in oxidative, inflammatory and apoptotic events in short-lived and long-lived mice testes [PDF]

, 2016
Aged testes undergo profound histological and morphological alterations leading to a reduced functionality. Here, we investigated whether variations in longevity affect the development of local inflammatory processes, the oxidative state and the ...
Bartke, Andrzej, Calandra, Ricardo Saul, Fang, Yimin, Frungieri, Monica Beatriz, Hill, Cristal Monique, Matzkin, Maria Eugenia, Miquet, Johanna Gabriela, Turyn, Daniel   +7 more
core   +2 more sources

HIV infection is associated with elevated biomarkers of immune activation in Ugandan adults with pneumonia. [PDF]

, 2019
IntroductionPneumonia is an important cause of morbidity and mortality in persons living with human immunodeficiency virus (HIV) infection. How immune activation differs among HIV-infected and HIV-uninfected adults with pneumonia is unknown.MethodsThe ...
Byanyima, Patrick, Chang, Emily G, Crothers, Kristina, Davis, J Lucian, Huang, Laurence, Hunt, Peter W, Kaswabuli, Sylvia, Lalitha, Rejani, Lederman, Michael M, Lin, Jue, Moisi, Daniela, Moore, Julia, Musisi, Emmanuel, Sanyu, Ingvar, Sessolo, Abdulwahab, Wang, Richard J, Worodria, William   +16 more
core   +2 more sources

The impact of prolonged blockade of the releasing hormone on alterations in cardiac macrophage polarisation subsequent to quercetin administration in rats

Mìžnarodnij Endokrinologìčnij Žurnal
Background. Cardiomyocytes represent the contractile units of the myocardium, while the maintenance and renewal of the extracellular matrix is a function of fibroblasts.
T.A. Voroshylova, V.I. Shepitko, Ye.V. Stetsuk, N.V. Boruta, O.V. Vilkhova, M.V. Rud, G.S. Puzyryov, O.V. Sych, А.A. Miahkokhlib   +8 more
doaj   +1 more source

Haptoglobin Polymorphism: A Novel Genetic Risk Factor for Celiac Disease Development and Its Clinical Manifestations [PDF]

, 2008
Background: Haptoglobin (Hp) α-chain alleles 1 and 2 account for 3 phenotypes that may influence the course of inflammatory diseases via biologically important differences in their antioxidant, scavenging, and immunomodulatory properties.
Altorjay, István, Barta, Zsolt, Dinya, T., Földi, I., Gyetvai, A., Hársfalvi, Jolán, Kapitany, A., Korponay-Szabó, Ilma Rita, Lakatos, Péter László, Mate, I., Nemes, E., Papp, Mária, Szathmari, E., Toth, L., Tumpek, J., Udvardy, M., Varvolgyi, C., Veres, Gábor   +17 more
core   +1 more source

Alterations in the polarization of liver M1/M2 macrophages upon long-term administration of triptorelin in rats

Mìžnarodnij Endokrinologìčnij Žurnal
Background. Liver macrophages play a pivotal role in maintaining the homeostasis of the liver and the entire body, they may be classified into three categories based on their origin.
M.V. Rud, Y.V. Stetsuk, V.I. Shepitko, O.V. Vilkhova, L.B. Pelypenko, O.V. Voloshyna, A.G. Sydorenko, H.P. Pavlenko, N.M. Sharlai, O.V. Sych   +9 more
doaj   +1 more source

CD163-positive tumor-associated macrophages and CD8-positive cytotoxic lymphocytes are powerful diagnostic markers for the therapeutic stratification of osteosarcoma patients: An immunohistochemical analysis of the biopsies fromthe French OS2006 phase 3 trial

OncoImmunology, 2017
The French phase 3 trial (OS 2006) testing zoledronic acid, an osteoclast inhibitor, with chemotherapy and surgery did not improve the outcome of patients with osteosarcoma (OS).
Anne Gomez-Brouchet, Claire Illac, Julia Gilhodes, Corinne Bouvier, Sébastien Aubert, Jean-Marc Guinebretiere, Béatrice Marie, Frédérique Larousserie, Natacha Entz-Werlé, Gonzague de Pinieux, Thomas Filleron, Véronique Minard, Vincent Minville, Eric Mascard, François Gouin, Marta Jimenez, Marie-Cécile Ledeley, Sophie Piperno-Neumann, Laurence Brugieres, Françoise Rédini   +19 more
doaj   +1 more source

Clinicopathological correlation of tumor-associated macrophages in Ewing sarcoma

Biomedical Papers, 2018
Aims: Tumor-associated macrophages (TAMs) are known markers playing complex roles in tumorigenesis. However, the function of TAMs in a variety of malignancies is not yet fully understood. The aim of this pilot study was to quantify the density of TAMs in
Marek Handl, Marketa Hermanova, Sylva Hotarkova, Jiri Jarkovsky, Peter Mudry, Tetiana Shatokhina, Marcela Vesela, Jaroslav Sterba, Iva Zambo   +8 more
doaj   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

Molecular and clinical characterization of CD163 expression via large-scale analysis in glioma

OncoImmunology, 2019
The expression and function of CD163 in glioma are not fully understood. In this report, we collected totally 1323 glioma samples from the Chinese Glioma Genome Atlas (CGGA) dataset, including 325 RNA-seq data and 301 mRNA microarray data, and 697 glioma
Shasha Liu, Chaoqi Zhang, Nomathamsanqa Resegofetse Maimela, Li Yang, Zhen Zhang, Yu Ping, Lan Huang, Yi Zhang   +7 more
doaj   +1 more source