Results 41 to 50 of about 49,329 (202)

Immuno-phenotyping of IDH-mutant grade 3 astrocytoma and IDH-wildtype glioblastoma reveals specific differences in cells of myeloid origin

OncoImmunology, 2021
Gliomas are heavily infiltrated with immune cells of myeloid origin. Past studies have shown that high-grade gliomas have a higher proportion of alternatively activated and suppressive myeloid cells when compared to low-grade gliomas, which correlate ...
Jayashree V. Raghavan, Raksha A. Ganesh, Pranali Sonpatki, Divya Naik, Arivusudar Everad John, Priyanka Arunachalam, Darshat Shah, Hari P. S., Akhila Lakshmikantha, Shibu Pillai, Komal Prasad Chandrachari, Kiran Mariswamappa, Sathyanarayana Lale, Nameeta Shah, Siddharth Jhunjhunwala   +14 more
doaj   +1 more source

CD163 [PDF]

American Journal of Clinical Pathology, 2004
Paraffin-section immunohistochemical analysis was performed using a monoclonal antibody against CD163 to evaluate the antibody's usefulness in identifying cells of monocyte/macrophage lineage in normal and neoplastic conditions. Normal human tissue samples and samples from 211 hematopoietic disorders and 115 nonhematopoietic neoplasms were examined ...
Sean K, Lau, Peiguo G, Chu, Lawrence M, Weiss   +2 more
openaire   +2 more sources

Prognostic Role of CD68+ and CD163+ Tumour-Associated Macrophages and PD-L1 Expression in Oral Squamous Cell Carcinoma: A Meta-Analysis

British Journal of Biomedical Science, 2023
Background: Oral squamous cell carcinoma (OSCC) is a common malignant cancer in humans. An abundance of tumour associated macrophages (TAMs) create an immunosuppressive tumour microenvironment (TME).
M. Chohan, Matthew Perry, P. Laurance-Young, Vehid M Salih, Andrew D. Foey   +4 more
semanticscholar   +1 more source

Recognition mechanisms of hemoglobin particles by monocytes – CD163 may just be one

Beilstein Journal of Nanotechnology, 2023
Hemoglobin-based oxygen carriers (HBOCs) as blood substitutes are one of the great hopes of modern transfusion and emergency medicine. After the major safety-relevant challenges of the last decades seem to be largely overcome, current developments have ...
Jonathan-Gabriel Nimz, Pichayut Rerkshanandana, Chiraphat Kloypan, Ulrich Kalus, Saranya Chaiwaree, Axel Pruß, Radostina Georgieva, Yu Xiong, Hans Bäumler   +8 more
doaj   +1 more source

Reduced Angiogenesis and Delayed Endochondral Ossification in CD163−/− Mice Highlights a Role of M2 Macrophages During Bone Fracture Repair

Journal of Orthopaedic Research, 2023
While recent studies showed that macrophages are critical for bone fracture healing, and lack of M2 macrophages have been implicated in models of delayed union, functional roles for specific M2 receptors have yet to be defined. Moreover, the M2 scavenger
Youliang Ren, Shiyang Zhang, Jason Weeks, J. Rangel-Moreno, Bin He, Thomas Xue, J. Rainbolt, Y. Morita, Ye Shu, Yuting Liu, S. Kates, E. Schwarz, C. Xie   +12 more
semanticscholar   +1 more source

Soluble ectodomain CD163 and extracellular vesicle-associated CD163 are two differently regulated forms of ‘soluble CD163’ in plasma

Scientific Reports, 2017
AbstractCD163 is the macrophage receptor for uptake of hemoglobin-haptoglobin complexes. The human receptor can be shed from the macrophage surface owing to a cleavage site for the inflammation-inducible TACE/ADAM17 enzyme. Accordingly, plasma ‘soluble CD163’ (sCD163) has become a biomarker for macrophage activity and inflammation.
Etzerodt, Anders, Berg, Ronan M. G., Plovsing, Ronni R., Andersen, Morten N., Bebien, Magali, Habbeddine, Mohamed, Lawrence, Toby, Moller, Holger J., Moestrup, Soren K.   +8 more
openaire   +3 more sources

Soluble CD163 predicts outcome in both chemoimmunotherapy and targeted therapy–treated mantle cell lymphoma

Blood Advances, 2023
Key Points • High level of the soluble macrophage marker CD163 is associated with shorter PFS and OS in MCL.• Soluble CD163 is prognostic in both rituximab-chemotherapy–treated and rituximab, ibrutinib and lenalidomide–treated MCL.
A. Nikkarinen, L. Lokhande, R. Amini, M. Jerkeman, A. Porwit, D. Molin, G. Enblad, A. Kolstad, R. Räty, M. Hutchings, C. Weibull, P. Hollander, S. Ek, I. Glimelius   +13 more
semanticscholar   +1 more source

Nanobodies against porcine CD163 as PRRSV broad inhibitor.

International Journal of Biological Macromolecules, 2023
PRRSV (Porcine Reproductive and Respiratory Syndrome Virus) is a major swine pathogen causing economic losses. To the date, effective broad PRRSV inhibitory strategies have not been available in practice yet.
Zhuofan Deng, Shengkun Zhang, Meiqi Sun, Haotian Yang, Ying Lu, Maopeng Wang, Weihuan Fang, Fushan Shi, Fang He   +8 more
semanticscholar   +1 more source

In vitro differentiation of porcine blood CD163− and CD163+ monocytes into functional dendritic cells

Immunobiology, 2004
Swine monocytes constitute a heterogeneous cell population containing subsets with distinct functional capacities or representing different maturational stages. Based on the expression of CD163, we have recently identified two monocyte subpopulations.
Chamorro, S., Revilla Calvo, Concepción, Gómez, Nuria, Álvarez, Belén, Alonso, Fernando, Ezquerra Martínez, Ángel, Domínguez, Javier   +6 more
openaire   +3 more sources

The Ratio of CD86+/CD163+ Macrophages Predicts Postoperative Recurrence in Stage II-III Colorectal Cancer

Frontiers in Immunology, 2021
Tumor-associated macrophages (TAMs) are pivotal for tumor progression and metastasis. We investigated the stromal CD86+TAM/CD163+TAM (CD86/CD163) ratio as a novel prognostic biomarker for stage II-III colorectal cancer (CRC).
Guozeng Xu, Lei Jiang, Cheng Ye, Guizhen Qin, Zhanxiong Luo, Yuzhen Mo, Jian Chen   +6 more
doaj   +1 more source