Results 51 to 60 of about 49,899 (288)

Alterations in the polarization of liver M1/M2 macrophages upon long-term administration of triptorelin in rats

Mìžnarodnij Endokrinologìčnij Žurnal
Background. Liver macrophages play a pivotal role in maintaining the homeostasis of the liver and the entire body, they may be classified into three categories based on their origin.
M.V. Rud, Y.V. Stetsuk, V.I. Shepitko, O.V. Vilkhova, L.B. Pelypenko, O.V. Voloshyna, A.G. Sydorenko, H.P. Pavlenko, N.M. Sharlai, O.V. Sych   +9 more
doaj   +1 more source

Clinicopathological correlation of tumor-associated macrophages in Ewing sarcoma

Biomedical Papers, 2018
Aims: Tumor-associated macrophages (TAMs) are known markers playing complex roles in tumorigenesis. However, the function of TAMs in a variety of malignancies is not yet fully understood. The aim of this pilot study was to quantify the density of TAMs in
Marek Handl, Marketa Hermanova, Sylva Hotarkova, Jiri Jarkovsky, Peter Mudry, Tetiana Shatokhina, Marcela Vesela, Jaroslav Sterba, Iva Zambo   +8 more
doaj   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

CD163+ macrophages are associated with a vulnerable plaque phenotype in human carotid plaques [Elektronisk resurs]

, 2020
Macrophages are a functionally heterogeneous group of immune cells abundant in atherosclerotic plaques. Macrophages expressing CD163 are associated with intraplaque hemorrhage and have previously been considered atheroprotective.
Nilsson, Jan,, Hultman, Karin,, Edsfeldt, Andreas,, Nitulescu, Mihaela,, Björkbacka, Harry,, Bengtsson, Eva,, Persson, Ana,, Lund University., Gonçalves, Isabel,   +8 more
core   +2 more sources

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Cell surface expression of CD163 in THP-1 cells.

, 2014
(A) Representative histograms of CD14 and CD163 expression. (B) Quantification of mean fluorescence intensity of CD163 and CD14 expression. (C) Quantification of percentages of CD163+/CD14+ cells and CD163−/CD14+ cells.
Hiromichi Takahashi (663363), Yuichiro Hasegawa (663366), Hikaru Uchida (663367), Noriyoshi Iriyama (663365), Masaru Nakagawa (663368), Makoto Makishima (294803), Yoshihiro Hatta (663364), Masami Takei (200276), Jin Takeuchi (200338)   +8 more
core   +1 more source

Vascular normalization confers an endothelial immune suppressive gene expression profile

Molecular Oncology, EarlyView.
We compare the immunoregulatory gene expression profiles of healthy endothelial cells or endothelial cells from tumors having a normalized endothelium (low leakage) with that of wild‐type tumors (high leakage) and observe that the wild‐type tumor endothelium exhibits immunostimulatory properties.
Liqun He, Michael Welsh
wiley   +1 more source

Serum LPS and CD163 Biomarkers Confirming the Role of Gut Dysbiosis in Overweight Patients with NASH

Diabetes, Metabolic Syndrome and Obesity, 2020
Mona A Hegazy,1 Sherif M Mogawer,1 Alshaimaa Rezk L R Alnaggar,1 Olfat A Ghoniem,2 Rasha M Abdel Samie1 1Internal Medicine Department, Kasr Alainy Hospital, Faculty of Medicine, Cairo University, Cairo, Egypt; 2Internal Medicine, Ministry of Health ...
Hegazy MA, Mogawer SM, Alnaggar ARLR, Ghoniem OA, Abdel Samie RM   +4 more
doaj  

MOESM2 of Preferential use of Siglec-1 or Siglec-10 by type 1 and type 2 PRRSV strains to infect PK15S1–CD163 and PK15S10–CD163 cells

, 2018
Additional file 2. Kinetics of intracellular and extracellular virus titers for 10 strains propagated in PK-15S1–CD163 and PK15S10–CD163 cells. Ten genetically distant PRRSV strains were inoculated in two cell lines. Cells and supernatants were collected
Jiexiong Xie (572624), Ivan Trus (5534489), Ruifang Wei (4625599), Bert Devriendt (145612), Hans Nauwynck (533091), Isaura Christiaens (5534486), Bo Yang (104813), Tingting Cui (564531)   +7 more
core   +1 more source

TRAIP Mediates Alcohol‐Induced Liver Injury through Regulating β‐catenin Ubiquitin Degradation via Direct Interaction

Advanced Science, EarlyView.
This study reveals that NF‐κB1‐driven TRAIP upregulation in ALD correlates with disease severity. Mechanistically, TRAIP directly binds β‐catenin via its CC domain and promotes its K48‐linked ubiquitination and degradation, which is independent of the GSK3β/β‐TrCP pathway.
Zhan Wu, Mingjiang Liu, Lijuan Liao, Zhaohong Mo, Wenli Xu, Linfeng Mao, Yubing Chen, Qiuli Xie, Ming Yao, Shilian Chen, Stephen Tomlinson, Sebastian Mueller, Songqing He, Guandou Yuan   +13 more
wiley   +1 more source