Results 21 to 30 of about 49,329 (202)

Targeting of CD163+ Macrophages in Inflammatory and Malignant Diseases [PDF]

International Journal of Molecular Sciences, 2020
The macrophage is a key cell in the pro- and anti-inflammatory response including that of the inflammatory microenvironment of malignant tumors. Much current drug development in chronic inflammatory diseases and cancer therefore focuses on the macrophage
M. Skytthe, J. Graversen, S. Moestrup
semanticscholar   +5 more sources

CD163 at the crossroads: a viral-exploited immunomodulator

Virology Journal
Porcine reproductive and respiratory syndrome virus (PRRSV) is a major pathogen in pigs and poses a significant economic threat to the pig industry. CD163 acts as a key cellular receptor for PRRSV infection, mediating viral entry into host cells.
Jiayong Tan, Jie Cheng, Xiaohui Yang, Jian Zhang, Huaqiang Yang   +4 more
doaj   +3 more sources

Highly Efficient Generation of Pigs Harboring a Partial Deletion of the CD163 SRCR5 Domain, Which Are Fully Resistant to Porcine Reproductive and Respiratory Syndrome Virus 2 Infection

Frontiers in Immunology, 2019
Porcine reproductive and respiratory syndrome virus (PRRSV) 1 and 2 differ in their recognition of CD163. Substitution of porcine CD163 SRCR5 domain with a human CD163-like SRCR8 confers resistance to PRRSV 1 but not PRRSV 2.
Xiaohong Liu, Yongchang Cao, Yaosheng Chen   +2 more
exaly   +3 more sources

Impact of Cox2, CD163, and Microvessel Density Expression on the Prediction of Relapse and Patients’ Outcome in Classical Hodgkin Lymphoma [PDF]

Middle East Journal of Cancer, 2022
Background: Tumor microenvironment, specifically tumor-associated macrophages, plays an important role in tumor initiation and progression. CD163 has been recognized as a valuable specific macrophage marker.
Rania Makboul, Abeer Refaiy, Rabab Mohamed, Alia Attia, Dalia Osama, Amany El Emary, Abeer Ibrahim   +6 more
doaj   +1 more source

Immunohistochemical expression of CD163 in colorectal carcinoma and its prognostic value

Journal of the Arab Society for Medical Research, 2023
Background/aim Colorectal cancer (CRC) is one of the most frequent cancers worldwide with one of the highest mortality rate. CD163 is a 130-KDa transmembrane protein, known to be involved in hemoglobin clearance by functioning as a receptor for ...
Noha N Yassen, Marwa E Shabana, Maha K Desouky, Manal A Badawi, Dalia M Abouelfadl   +4 more
doaj   +1 more source

Expression of scavenger receptors CD163, CD204, and CD206 on macrophages in patients with pulmonary tuberculosis

Бюллетень сибирской медицины, 2023
The aim of the study was to evaluate the expression of scavenger receptors (CD163, CD204, CD206) on macrophages in patients with pulmonary tuberculosis, depending on the clinical form of the disease and sensitivity of the pathogen to anti-tuberculosis ...
E. G. Churina, A. V. Popova, O. I. Urazova, M. R. Patysheva, Ju. V. Kolobovnikova, S. P. Chumakova   +5 more
doaj   +1 more source

Relationship of Tumor-Associated Macrophage Population Detected by CD68 PG-M1, CD68 KP1, and CD163 with Latent EBV Infection and Prognosis in Classical Hodgkin Lymphoma

Türk Patoloji Dergisi, 2021
Objective: To evaluate the quantity of tumor-associated macrophages (TAMs) in cases of Hodgkin Lymphoma of classical type (cHL), and to reveal possible associations between TAM intensity and latent Epstein-Barr virus (EBV) infection, overall survival ...
Hanife Seda MAVILI, Aydın ISISAG, Ayca TAN, Mine MISKIOGLU, Lale SAKA BARAZ, Nalan NESE   +5 more
doaj   +1 more source

CD163 expression in leukemia cutis [PDF]

Journal of Cutaneous Pathology, 2010
Background: Proper diagnosis of myeloid leukemia cutis (LC) is of great clinical importance but can be difficult because no single immunohistochemical marker is adequately sensitive or specific for definitive diagnosis. Thus, a broader panel of markers is often desirable.
Harms, Paul W., Bandarchi, Bizhan, Ma, Linglei   +2 more
openaire   +3 more sources

CD163+ macrophages monitor enhanced permeability at the blood–dorsal root ganglion barrier

Journal of Experimental Medicine, 2023
The blood–DRG barrier is composed of endothelial cells with high permeability and is monitored by a subset of CD163+ perivascular macrophages, a process that is arteriovenously zonated.
Harald Lund, Matthew A. Hunt, Zerina Kurtović, Katalin Sandor, Paul B Kägy, Noah Fereydouni, Anais Julien, C. Göritz, E. Vázquez-Liébanas, Maarja Andaloussi Mäe, A. Jurczak, Jinming Han, Keying Zhu, Robert A Harris, J. Lampa, J. Graversen, A. Etzerodt, L. Haglund, Tony L. Yaksh, Camilla I. Svensson   +19 more
semanticscholar   +1 more source

PD-L1 blockade restores CAR T cell activity through IFN-γ-regulation of CD163+ M2 macrophages

Journal for ImmunoTherapy of Cancer, 2022
Background The immune suppressive tumor microenvironment (TME) that inhibits T cell infiltration, survival, and antitumor activity has posed a major challenge for developing effective immunotherapies for solid tumors.
Y. Yamaguchi, J. Gibson, Kevin Ou, L. Lopez, Rachel H. Ng, Neena Leggett, Vanessa D. Jonsson, Jelani C. Zarif, Peter P. Lee, Xiuli Wang, Catalina Martinez, T. Dorff, S. Forman, S. Priceman   +13 more
semanticscholar   +1 more source