Results 11 to 20 of about 49,329 (202)

Prognostic and Predictive Value of CD163+ Macrophages for Neoadjuvant Chemotherapy in Osteosarcoma [PDF]

Biomedicines
Background: The CD163+ macrophage is considered a key component of the tumor immune microenvironment (TIME) in osteosarcoma (OS) in relation to tumor progression and chemotherapy resistance.
Yuejun Luo, Bo Wang, Wanjiang Feng, Zibo Xu, Hongyu Wu, Ziming Yan, Haoyu Guo, Weifeng Liu   +7 more
doaj   +2 more sources

Role of CD163 in PRRSV infection.

Virology
Porcine reproductive and respiratory syndrome virus (PRRSV) is a highly infectious agent that poses a significant economic threat to the global swine industry.
R. Rowland, A. Brandariz-Nuñez
semanticscholar   +3 more sources

Macrophage Cluster of Differentiation 163 promotes post‐infarction cardiac repair and preserves left ventricular function via osteopontin [PDF]

Clinical and Translational Medicine
Background Cardiac macrophages (cMacs) have been implicated in myocardial repair following myocardial infarction (MI), yet their therapeutic potential in ischaemic cardiomyopathy (ICM) remains limited by an incomplete understanding of their molecular ...
Jingyu Chen, Linjian Chen, Wei Huang, Gang Wang, Lin Wang, Wanchun Mei, Wei Ni, Yang Liu, Licheng Ding, Xiaofeng Ge, Zhaokai Li, Jing Yu, Shufen Huang, Jiayi Lin, Yifan Chen, Binni Cai, Peng Zhang, Cuilian Dai, Binbin Liu   +18 more
doaj   +2 more sources

The Cryo-EM structure of human CD163 bound to haptoglobin-hemoglobin reveals molecular mechanisms of hemoglobin scavenging

Nature Communications
CD163, a macrophage-specific receptor, plays a critical role in scavenging hemoglobin released during hemolysis, protecting against oxidative effects of heme iron.
Anders Etzerodt, Jakob Hauge Mikkelsen, Morten Torvund-Jensen, Dorle Hennig, Thomas Boesen, Jonas Heilskov Graversen, Søren Kragh Moestrup, Justin M. Kollman, Christian Brix Folsted Andersen   +8 more
doaj   +2 more sources

The Role of Soluble CD163 (sCD163) in Human Physiology and Pathophysiology

Cells
Soluble CD163 (sCD163) is a circulating inflammatory mediator, indicative of acute and chronic, systemic and non-systemic inflammatory conditions. It is the cleavage outcome, consisting of almost the entire extracellular domain, of the CD163, a receptor ...
Constantinos Mikelis, Antonios Chatzigeorgiou, Md Sanaullah Sajib   +2 more
exaly   +2 more sources

The CD163/TWEAK/Fn14 axis: A potential therapeutic target for alleviating inflammatory bone loss

Journal of Orthopaedic Translation
Objective: Osteoclast (OC) over-activation is an important cause of bone loss that is strongly correlated with inflammation. Although the CD163/TWEAK/Fn14 axis has been implicated in several inflammatory pathologies, its contributions to inflammatory ...
Ji-kun Qian, Yuan Ma, Xuan Huang, Xiao-ran Li, Ya-fei Xu, Zi-ying Liu, Yuan Gu, Ke Shen, Liang-jie Tian, Yu-tian Wang, Ning-ning Cheng, Bing-sheng Yang, Kui-yuan Huang, Yu Chai, Guan-qiao Liu, Nai-qian Cui, Song-yun Deng, Nan Jiang, Dao-rong Xu, Bin Yu   +19 more
doaj   +2 more sources

CD163 and its role in inflammation

Folia Histochemica et Cytobiologica, 2011
Mononuclear phagocytes represent a heterogeneous population of cells with individual subpopulations exerting different pro- or anti-inflammatory functions.
Lech Chyczewski, Marek Bielecki, Emila Sławińska, Richard Silver, Krzysztof Kowal, Otylia Kowal-Bielecka   +5 more
doaj   +5 more sources

Prognostic significance of CD163+ tumor-associated macrophages in colorectal cancer

World Journal of Surgical Oncology, 2021
Background This study aimed to explore the prognostic significance of tumor-associated macrophage (TAM) infiltration in colorectal cancer (CRC) patients.
Tao Xue, Kejing Yan, Yiqi Cai, Jiancheng Sun, Zhejing Chen, Xiaolei Chen, Wenyi Wu   +6 more
doaj   +2 more sources

Calcium-dependent oligomerization of scavenger receptor CD163 facilitates the endocytosis of ligands

Nature Communications
Scavenger receptor CD163 is a marker of M2 type macrophages that play important roles in anti-inflammatory processes. The most extensively studied function of CD163 is related to the elimination of hemoglobin-haptoglobin (Hb-Hp) complexes, to prevent ...
Hua Xu, Xiaohui Song, Xiao-dong Su
doaj   +2 more sources

CD163ΔSRCR5 MARC-145 Cells Resist PRRSV-2 Infection via Inhibiting Virus Uncoating, Which Requires the Interaction of CD163 With Calpain 1

Frontiers in Microbiology, 2020
Porcine alveolar macrophages without the CD163 SRCR5 domain are resistant to porcine reproductive and respiratory syndrome virus (PRRSV) infection. However, whether the deletion of CD163 SRCR5 in MARC-145 cells confers resistance to PRRSV and interaction
Xiaohong Liu, Yaosheng Chen, Chunhe Guo   +2 more
exaly   +3 more sources