Results 11 to 20 of about 49,899 (288)

CD163 at the crossroads: a viral-exploited immunomodulator

Virology Journal
Porcine reproductive and respiratory syndrome virus (PRRSV) is a major pathogen in pigs and poses a significant economic threat to the pig industry. CD163 acts as a key cellular receptor for PRRSV infection, mediating viral entry into host cells.
Jiayong Tan, Jie Cheng, Xiaohui Yang, Jian Zhang, Huaqiang Yang   +4 more
doaj   +4 more sources

Soluble ectodomain CD163 and extracellular vesicle-associated CD163 are two differently regulated forms of ‘soluble CD163’ in plasma [PDF]

Scientific Reports, 2017
AbstractCD163 is the macrophage receptor for uptake of hemoglobin-haptoglobin complexes. The human receptor can be shed from the macrophage surface owing to a cleavage site for the inflammation-inducible TACE/ADAM17 enzyme. Accordingly, plasma ‘soluble CD163’ (sCD163) has become a biomarker for macrophage activity and inflammation.
Etzerodt, Anders, Berg, Ronan M. G., Plovsing, Ronni R., Andersen, Morten N., Bebien, Magali, Habbeddine, Mohamed, Lawrence, Toby, Moller, Holger J., Moestrup, Soren K.   +8 more
openaire   +4 more sources

Peripheral blood CD163(+) monocytes and soluble CD163 in dry and neovascular age‐related macular degeneration [PDF]

The FASEB Journal, 2020
Abstract Macrophages are the main infiltrating immune cells in choroidal neovascularization (CNV), a hallmark of the human wet, or neovascular age‐related macular degeneration (AMD). Due to their plasticity and ability to adapt to the local microenvironment in a tissue‐dependent manner, macrophages display polar ...
Daftarian, Narsis, Zandi, Souska, Piryaie, Golbarg, Nikougoftar Zarif, Mahin, Ranaei Pirmardan, Ehsan, Yamaguchi, Muneo, Behzadian Nejad, Qurban, Hasanpour, Hossein, Samiei, Shahram, Pfister, Isabel B., Soheili, Zahra‐Soheila, Nakao, Shintaro, Barakat, Aliaa, Garweg, Justus G., Ahmadieh, Hamid, Hafezi‐Moghadam, Ali   +15 more
openaire   +5 more sources

CD163 and its role in inflammation [PDF]

Folia Histochemica et Cytobiologica, 2011
Mononuclear phagocytes represent a heterogeneous population of cells with individual subpopulations exerting different pro- or anti-inflammatory functions. CD163 is a monocyte/macrophage specific marker expressed predominantly on cells which possess strong anti-inflammatory potential.
Krzysztof Kowal, Silver, Richard, Sławińska, Emila, Marek Bielecki, Chyczewski, Lech, Otylia Kowal-Bielecka   +5 more
core   +6 more sources

CD163 expression in leukemia cutis [PDF]

Journal of Cutaneous Pathology, 2010
Background: Proper diagnosis of myeloid leukemia cutis (LC) is of great clinical importance but can be difficult because no single immunohistochemical marker is adequately sensitive or specific for definitive diagnosis. Thus, a broader panel of markers is often desirable.
Harms, Paul W., Bandarchi, Bizhan, Ma, Linglei   +2 more
openaire   +5 more sources

In vitro differentiation of porcine blood CD163− and CD163+ monocytes into functional dendritic cells

Immunobiology, 2004
Swine monocytes constitute a heterogeneous cell population containing subsets with distinct functional capacities or representing different maturational stages. Based on the expression of CD163, we have recently identified two monocyte subpopulations.
Chamorro, S., Revilla Calvo, Concepción, Gómez, Nuria, Álvarez, Belén, Alonso, Fernando, Ezquerra Martínez, Ángel, Domínguez, Javier   +6 more
openaire   +4 more sources

Preferential use of Siglec-1 or Siglec-10 by type 1 and type 2 PRRSV strains to infect PK15S1–CD163 and PK15S10–CD163 cells [PDF]

Veterinary Research, 2018
Cellular entry mediators define whether the cell is permissive to PRRSV infection. Porcine sialoadhesin (pSn, Siglec-1) and CD163 are main entry mediators facilitating infection of porcine macrophages by PRRSV.
Jiexiong Xie, Isaura Christiaens, Bo Yang, Ivan Trus, Bert Devriendt, Tingting Cui, Ruifang Wei, Hans J. Nauwynck   +7 more
doaj   +2 more sources

Pig macrophages with site-specific edited CD163 decrease the susceptibility to infection with porcine reproductive and respiratory syndrome virus

Journal of Integrative Agriculture, 2023
Porcine reproductive and respiratory syndrome (PRRS) is recognized as one of the most infectious viral diseases of swine. Although Cluster of differentiation 163 (CD163) is identified as an essential receptor for mediating PRRS virus (PRRSV) infection ...
Kui XU, Yan-rong ZHOU, Hai-tao SHANG, Chang-jiang XU, Ran TAO, Wan-jun HAO, Sha-sha LIU, Yu-lian MU, Shao-bo XIAO, Kui LI   +9 more
doaj   +2 more sources

Dysregulation of the CD163-Haptoglobin Axis in the Airways of COPD Patients

Cells, 2021
Pulmonary iron levels are increased in chronic obstructive pulmonary disease (COPD) patients. Iron causes oxidative stress and is a nutrient for pathogenic bacteria. Iron may therefore play an important role in the pathophysiology of COPD.
Andrew Higham, James M. Baker, Natalie Jackson, Rajesh Shah, Simon Lea, Dave Singh   +5 more
doaj   +2 more sources

The CD163/TWEAK/Fn14 axis: A potential therapeutic target for alleviating inflammatory bone loss

Journal of Orthopaedic Translation
Objective: Osteoclast (OC) over-activation is an important cause of bone loss that is strongly correlated with inflammation. Although the CD163/TWEAK/Fn14 axis has been implicated in several inflammatory pathologies, its contributions to inflammatory ...
Ji-kun Qian, Yuan Ma, Xuan Huang, Xiao-ran Li, Ya-fei Xu, Zi-ying Liu, Yuan Gu, Ke Shen, Liang-jie Tian, Yu-tian Wang, Ning-ning Cheng, Bing-sheng Yang, Kui-yuan Huang, Yu Chai, Guan-qiao Liu, Nai-qian Cui, Song-yun Deng, Nan Jiang, Dao-rong Xu, Bin Yu   +19 more
doaj   +2 more sources