Results 11 to 20 of about 126,758 (293)
CD19 EKSİKLİĞİ TANISINDA RFLP YÖNTEMİNİN KULLANIMI
Genel Tıp Dergisi, 2021 B lenfosit yüzeyinde bulunan CD19 molekülü olgun B hücrelerinde CD21, CD81, CD225 ile birlikte CD19 kompleksini oluşturur ve antijen uyarısı ile birlikte B lenfosit aktivasyonunu düzenler. CD19 molekülünü kodlayan gende oluşacak mutasyonlar, CD19 protein
İsmail Reisli +7 more
doaj +2 more sources
Getting CD19 Into Shape: Expression of Natively Folded “Difficult-to- Express” CD19 for Staining and Stimulation of CAR-T Cells [PDF]
Frontiers in Bioengineering and Biotechnology, 2020 The transmembrane protein CD19 is exclusively expressed on normal and malignant B cells and therefore constitutes the target of approved CAR-T cell-based cancer immunotherapies. Current efforts to assess CAR-T cell functionality in a quantitative fashion
Elisabeth Lobner +7 more
doaj +2 more sources
A CD19/Fc fusion protein for detection of anti-CD19 chimeric antigen receptors [PDF]
Journal of Translational Medicine, 2013 Chimeric Antigen Receptors (CARs) consist of the antigen-recognition portion of a monoclonal antibody fused to an intracellular signaling domain capable of activating T-cells. CARs displayed on the surface of transduced cells perform non-MHC-restricted antigen recognition and activating intracellular signaling pathways for induction of target cytolysis,
De Oliveira, SN +5 more
core +10 more sources
T-Cell Depleted Haploidentical Transplantation in Children With Hematological Malignancies: A Comparison Between CD3+/CD19+ and TCRαβ+/CD19+ Depletion Platforms [PDF]
Frontiers in Oncology, 2022 BackgroundT-cell depleted (TCD) haploidentical transplantation using CD3+/CD19+ and TCRαβ+/CD19+ depletion techniques has been increasingly used in children with hematological malignancies.
Marta Gonzalez-Vicent +12 more
doaj +2 more sources
Cells, 2023 The efficacy of CD19-specific CAR T cells in the treatment of leukemia/lymphoma relies, at least in part, on the unique properties of the particular CAR and the presence of healthy B cells that enhance the target cell lysis and cytokine secretion through
Andreas A. Hombach +4 more
doaj +2 more sources
The Physiologic Role of CD19 Cytoplasmic Tyrosines [PDF]
Immunity, 2002 The physiologic role of eight CD19 tyrosines was examined in CD19-knockout mice expressing transgenic CD19 constructs. CD19 Y482 and Y513 were essential for normal B cell biology, including differentiation of B1 and marginal zone B cells and for T-dependent and -independent antibody responses.
Wang, Yue +5 more
openaire +3 more sources
Tandem CAR T-cells targeting CD19 and NKG2DL can overcome CD19 antigen escape in B-ALL [PDF]
Frontiers in ImmunologyIntroductionChimeric antigen receptor (CAR) T-cell therapies have achieved remarkable success in treating B-cell malignancies, including acute lymphoblastic leukemia (B-ALL).
Jennifer Bolsée +5 more
doaj +2 more sources
Overcoming CAR-Mediated CD19 Downmodulation and Leukemia Relapse with T Lymphocytes Secreting Anti-CD19 T-cell Engagers. [PDF]
, 2022 Chimeric antigen receptor (CAR)–modified T cells have revolutionized the treatment of CD19-positive hematologic malignancies. Although anti-CD19 CAR-engineered autologous T cells can induce remission in patients with B-cell acute lymphoblastic ...
Álvarez-Vallina, Luis +2 more
core +4 more sources
Targeting the CD19/CD21 complex on B cells in the mixed lymphocyte reaction [PDF]
, 2022 B cells exert antigen presenting functions at the crossroad between immune activation and tolerance induction, a fate notably governed by the B Cell Receptor (BCR) response regulator CD19/CD21 complex. This duality in B cells raises a particular interest
Broc, Sabine
core +1 more source
OncoImmunology, 2020 In our previous studies, using a B cell vaccine (scFv-Her2), the targeting of tumor-associated antigen Her2 (human epidermal growth factor receptor-2) to B cells via the anti-CD19 single chain variable fragment (scFv) was shown to augment tumor-specific ...
Zhuangwei Lv +10 more
doaj +1 more source