CD19 EKSİKLİĞİ TANISINDA RFLP YÖNTEMİNİN KULLANIMI
Genel Tıp Dergisi, 2021 B lenfosit yüzeyinde bulunan CD19 molekülü olgun B hücrelerinde CD21, CD81, CD225 ile birlikte CD19 kompleksini oluşturur ve antijen uyarısı ile birlikte B lenfosit aktivasyonunu düzenler. CD19 molekülünü kodlayan gende oluşacak mutasyonlar, CD19 protein
İsmail Reisli +7 more
doaj +2 more sources
Getting CD19 Into Shape: Expression of Natively Folded “Difficult-to- Express” CD19 for Staining and Stimulation of CAR-T Cells [PDF]
Frontiers in Bioengineering and Biotechnology, 2020 The transmembrane protein CD19 is exclusively expressed on normal and malignant B cells and therefore constitutes the target of approved CAR-T cell-based cancer immunotherapies. Current efforts to assess CAR-T cell functionality in a quantitative fashion
Elisabeth Lobner +7 more
doaj +2 more sources
T-Cell Depleted Haploidentical Transplantation in Children With Hematological Malignancies: A Comparison Between CD3+/CD19+ and TCRαβ+/CD19+ Depletion Platforms [PDF]
Frontiers in Oncology, 2022 BackgroundT-cell depleted (TCD) haploidentical transplantation using CD3+/CD19+ and TCRαβ+/CD19+ depletion techniques has been increasingly used in children with hematological malignancies.
Marta Gonzalez-Vicent +12 more
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Cells, 2023 The efficacy of CD19-specific CAR T cells in the treatment of leukemia/lymphoma relies, at least in part, on the unique properties of the particular CAR and the presence of healthy B cells that enhance the target cell lysis and cytokine secretion through
Andreas A. Hombach +4 more
doaj +2 more sources
A CD19/Fc fusion protein for detection of anti-CD19 chimeric antigen receptors [PDF]
Journal of Translational Medicine, 2013 Chimeric Antigen Receptors (CARs) consist of the antigen-recognition portion of a monoclonal antibody fused to an intracellular signaling domain capable of activating T-cells. CARs displayed on the surface of transduced cells perform non-MHC-restricted antigen recognition and activating intracellular signaling pathways for induction of target cytolysis,
De Oliveira, SN +5 more
core +10 more sources
Tandem CAR T-cells targeting CD19 and NKG2DL can overcome CD19 antigen escape in B-ALL [PDF]
Frontiers in ImmunologyIntroductionChimeric antigen receptor (CAR) T-cell therapies have achieved remarkable success in treating B-cell malignancies, including acute lymphoblastic leukemia (B-ALL).
Jennifer Bolsée +5 more
doaj +2 more sources
Overcoming CAR-Mediated CD19 Downmodulation and Leukemia Relapse with T Lymphocytes Secreting Anti-CD19 T-cell Engagers. [PDF]
, 2022 Chimeric antigen receptor (CAR)–modified T cells have revolutionized the treatment of CD19-positive hematologic malignancies. Although anti-CD19 CAR-engineered autologous T cells can induce remission in patients with B-cell acute lymphoblastic ...
Álvarez-Vallina, Luis +2 more
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Targeting the CD19/CD21 complex on B cells in the mixed lymphocyte reaction [PDF]
, 2022 B cells exert antigen presenting functions at the crossroad between immune activation and tolerance induction, a fate notably governed by the B Cell Receptor (BCR) response regulator CD19/CD21 complex. This duality in B cells raises a particular interest
Broc, Sabine
core +1 more source
Self-Immolative Carbamate Linkers for CD19-Budesonide Antibody-Drug Conjugates [PDF]
, 2023 Antibody-drug conjugates consist of potent small molecule payloads linked to a targeting antibody. Payloads must possess a viable functional group by which a linker for conjugation can be attached.
Axel, Hernandez, Jr. +12 more
core +2 more sources
FOXP1 Knockdown Reprograms Th9 CAR-T Cells to Overcome Antigen Escape. [PDF]
Adv Sci (Weinh)FOXP1 knockdown enhances Th9 CAR‐T cell function by promoting IL‐9 production, effector activation, and reduced exhaustion. Reprogrammed Th9 CAR‐T cells strengthen direct tumor killing and activate endogenous antitumor immunity through dendritic cells and CD8+ T cells, thereby suppressing both antigen‐positive and antigen‐loss tumor growth and ...
Zhu Y +14 more
europepmc +2 more sources