Results 21 to 30 of about 126,758 (293)

Rejection of Experimental Hodgkins Lymphoma by T-cells Engineered with a CD19 Chimeric Antigen Receptor [PDF]

, 2012
T cells engineered to express chimeric receptors combining an external antibody binding domain with the CD3ζ T cell receptor (TCR) internal domain for triggering cell activation are being used for immunotherapeutic targeting of tumour cells in a non-HLA ...
Cheadle, Eleanor, Johannessen, Ingolfur, Talbot, Simon, Cheadle, Eleanor J, Crawford, Dorothy, Gilham, David, Gilham, David E, Johannessen, Ingo, Swanson, Anna   +8 more
core   +1 more source

Purification and Immunophenotypic Characterization of Human CD19+CD24hiCD38hi and CD19+CD24hiCD27+ B Cells [PDF]

, 2021
Regulatory B cells (Bregs) have immunosuppressive capacity, primarily via the production of IL-10. IL-10 expression and immunosuppression have been described in a number of human B cell subsets, two of which include the CD19+CD24hiCD38hi and CD19+CD24hiCD27+ populations.
Bradford, HF, Mauri, C
openaire   +3 more sources

Preclinical Assessment of Efficacy and Safety Analysis of CAR-T Cells (ISIKOK-19) Targeting CD19-Expressing B-Cells for the First Turkish Academic Clinical Trial with Relapsed/Refractory ALL and NHL Patients

Turkish Journal of Hematology, 2020
Objective: Relapsed and refractory CD19-positive B-cell acute lymphoblastic leukemia (ALL) and non-Hodgkin lymphoma (NHL) are the focus of studies on hematological cancers.
Cihan Taştan, Derya Dilek Kançağı, Raife Dilek Turan, Bulut Yurtsever, Didem Çakırsoy, Selen Abanuz, Muhammet Yılancı, Utku Seyis, Samed Özer, Selin Mert, Cavit Kerem Kayhan, Fatma Tokat, Merve Açıkel Elmas, Selçuk Birdoğan, Serap Arbak, Koray Yalçın, Aslıhan Sezgin, Ebru Kızılkılıç, Cansu Hemşinlioğlu, Ümit İnce, Siret Ratip, Ercüment Ovalı   +21 more
doaj   +1 more source

Efficient Transduction of T-Lymphocytes by Lentiviral Particles in Oncoimmunological Studies

Клиническая онкогематология, 2020
Aim. To compare different methods of lentivirus concentration in order to select the best way of providing high-level transduction for generating laboratory CAR-T cells. Materials & Methods. Concentration of lentiviral supernatant was carried out by 4
Ekaterina Konstantinovna Zaikova, K. A. Levchuk, D. Yu. Pozdnyakov, A. A. Daks, A. Yu. Zaritskey, A. V. Petukhov   +5 more
doaj   +1 more source

CD19-Directed CAR T Cells Treatment in a Patient with Refractory DLBCL and CNS Involvement

healthbook TIMES. Oncology Hematology, 2019
Introduction Diffuse large B-cell lymphoma (DLBCL) is the most common neoplasm of the lymphatic system. Treatment and clinical management are difficult in the relapsed/refractory (R/R) setting.
Antonia Maria S. Müller, Alexander Ring
doaj   +1 more source

Which one is better for refractory/relapsed acute B-cell lymphoblastic leukemia: Single-target (CD19) or dual-target (tandem or sequential CD19/CD22) CAR T-cell therapy?

Blood Cancer Journal, 2023
CD19 chimeric antigen receptor (CAR) T-cell therapy has shown great success against B-cell acute lymphoblastic leukemia (B-ALL). Tandem and sequential CD19/CD22 dual-target CAR T-cell therapies have been developed to reduce the possibility of CD19 ...
Sining Liu, Xinyue Zhang, Haiping Dai, Wei Cui, Jia Yin, Zheng Li, Xiao Yang, Chunxiu Yang, Shengli Xue, Huiying Qiu, Miao Miao, Suning Chen, Zhengming Jin, Chengcheng Fu, Caixia Li, Aining Sun, Yue Han, Ying Wang, Lei Yu, Depei Wu, Qingya Cui, Xiaowen Tang   +21 more
doaj   +1 more source

A Lower Proportion of Regulatory B Cells in Patients with Henoch-Schoenlein Purpura Nephritis. [PDF]

PLoS ONE, 2016
BACKGROUND:Henoch-Schoenlein purpura is the one of most common types of systemic vasculitis that involves impaired renal function and Henoch-Schoenlein purpura nephritis (HSPN).
Xintong Hu, Jiandong Tai, Zhihui Qu, Songchen Zhao, Li Zhang, Man Li, Xiguang Sun, Yanfang Jiang   +7 more
doaj   +1 more source

Self-Immolative Carbamate Linkers for CD19-Budesonide Antibody-Drug Conjugates

, 2023
Antibody-drug conjugates consist of potent small molecule payloads linked to a targeting antibody. Payloads must possess a viable functional group by which a linker for conjugation can be attached.
Axel, Hernandez, Jr., Martin, Hayes, Michael, McPherson, Agnieszka, Bischoff, Thomas, Vargo, Margaret, Fettis, Lu, Wang, Yu, Tian, Adrian, Hobson, Ying, Jia, Jason, Oh, Christopher, Marvin, Theresa, Dunstan   +12 more
core   +1 more source

Generation and characterization of CD19-iCre mice as a tool for efficient and specific conditional gene targeting in B cells

Scientific Reports, 2021
The Cre/loxP system is a powerful tool for generating conditional gene knockout (KO) mice and elucidate gene function in vivo. CD19-Cre and Mb1-iCre transgenic mice are commonly used for generating B cell-specific KO mice and investigate the development,
Tomoharu Yasuda, Yuichi Saito, Chisato Ono, Kazuhiko Kawata, Akemi Baba, Yoshihiro Baba   +5 more
doaj   +1 more source

Perspectives of Fc engineered antibodies in CD19 targeting immunotherapies in pediatric B-cell precursor acute lymphoblastic leukemia

OncoImmunology, 2018
CD19 immunotherapies based on T cells opened new avenues in the treatment of pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL). However, Fc engineered CD19 antibodies may also bear great potential.
Christian Kellner, Matthias Peipp, Martin Gramatzki, Martin Schrappe, Denis M. Schewe   +4 more
doaj   +1 more source