Results 21 to 30 of about 134,446 (292)

Rejection of Experimental Hodgkins Lymphoma by T-cells Engineered with a CD19 Chimeric Antigen Receptor [PDF]

, 2012
T cells engineered to express chimeric receptors combining an external antibody binding domain with the CD3ζ T cell receptor (TCR) internal domain for triggering cell activation are being used for immunotherapeutic targeting of tumour cells in a non-HLA ...
Cheadle, Eleanor, Johannessen, Ingolfur, Talbot, Simon, Cheadle, Eleanor J, Crawford, Dorothy, Gilham, David, Gilham, David E, Johannessen, Ingo, Swanson, Anna   +8 more
core   +1 more source

CD19-targeting fusion protein combined with PD1 antibody enhances anti-tumor immunity in mouse models

OncoImmunology, 2020
In our previous studies, using a B cell vaccine (scFv-Her2), the targeting of tumor-associated antigen Her2 (human epidermal growth factor receptor-2) to B cells via the anti-CD19 single chain variable fragment (scFv) was shown to augment tumor-specific ...
Zhuangwei Lv, Ping Zhang, Dandan Li, Mengting Qin, Longzhu Nie, Xiaoqian Wang, Li Ai, Zhaozu Feng, Woodvine Otieno Odhiambo, Yunfeng Ma, Yanhong Ji   +10 more
doaj   +1 more source

Preclinical Assessment of Efficacy and Safety Analysis of CAR-T Cells (ISIKOK-19) Targeting CD19-Expressing B-Cells for the First Turkish Academic Clinical Trial with Relapsed/Refractory ALL and NHL Patients

Turkish Journal of Hematology, 2020
Objective: Relapsed and refractory CD19-positive B-cell acute lymphoblastic leukemia (ALL) and non-Hodgkin lymphoma (NHL) are the focus of studies on hematological cancers.
Cihan Taştan, Derya Dilek Kançağı, Raife Dilek Turan, Bulut Yurtsever, Didem Çakırsoy, Selen Abanuz, Muhammet Yılancı, Utku Seyis, Samed Özer, Selin Mert, Cavit Kerem Kayhan, Fatma Tokat, Merve Açıkel Elmas, Selçuk Birdoğan, Serap Arbak, Koray Yalçın, Aslıhan Sezgin, Ebru Kızılkılıç, Cansu Hemşinlioğlu, Ümit İnce, Siret Ratip, Ercüment Ovalı   +21 more
doaj   +1 more source

CD19-Directed CAR T Cells Treatment in a Patient with Refractory DLBCL and CNS Involvement

healthbook TIMES. Oncology Hematology, 2019
Introduction Diffuse large B-cell lymphoma (DLBCL) is the most common neoplasm of the lymphatic system. Treatment and clinical management are difficult in the relapsed/refractory (R/R) setting.
Antonia Maria S. Müller, Alexander Ring
doaj   +1 more source

Efficient Transduction of T-Lymphocytes by Lentiviral Particles in Oncoimmunological Studies

Клиническая онкогематология, 2020
Aim. To compare different methods of lentivirus concentration in order to select the best way of providing high-level transduction for generating laboratory CAR-T cells. Materials & Methods. Concentration of lentiviral supernatant was carried out by 4
Ekaterina Konstantinovna Zaikova, K. A. Levchuk, D. Yu. Pozdnyakov, A. A. Daks, A. Yu. Zaritskey, A. V. Petukhov   +5 more
doaj   +1 more source

Which one is better for refractory/relapsed acute B-cell lymphoblastic leukemia: Single-target (CD19) or dual-target (tandem or sequential CD19/CD22) CAR T-cell therapy?

Blood Cancer Journal, 2023
CD19 chimeric antigen receptor (CAR) T-cell therapy has shown great success against B-cell acute lymphoblastic leukemia (B-ALL). Tandem and sequential CD19/CD22 dual-target CAR T-cell therapies have been developed to reduce the possibility of CD19 ...
Sining Liu, Xinyue Zhang, Haiping Dai, Wei Cui, Jia Yin, Zheng Li, Xiao Yang, Chunxiu Yang, Shengli Xue, Huiying Qiu, Miao Miao, Suning Chen, Zhengming Jin, Chengcheng Fu, Caixia Li, Aining Sun, Yue Han, Ying Wang, Lei Yu, Depei Wu, Qingya Cui, Xiaowen Tang   +21 more
doaj   +1 more source

A Lower Proportion of Regulatory B Cells in Patients with Henoch-Schoenlein Purpura Nephritis. [PDF]

PLoS ONE, 2016
BACKGROUND:Henoch-Schoenlein purpura is the one of most common types of systemic vasculitis that involves impaired renal function and Henoch-Schoenlein purpura nephritis (HSPN).
Xintong Hu, Jiandong Tai, Zhihui Qu, Songchen Zhao, Li Zhang, Man Li, Xiguang Sun, Yanfang Jiang   +7 more
doaj   +1 more source

In planta transient recombinant production of a bispecific T-cell engager: Blinatumomab [PDF]

Iran Agricultural Research
Bispecific T-cell engagers (BiTEs) are increasingly being recognized as promising therapeutic molecules in tumor management. However, these largely artificial and complex antibody-based molecules are often difficult to express in conventional platforms ...
Saeideh Dianatkhah, Hiremath Chaitra, Melnik Stanislav, Lin Sun, Amin Ramezani, Ali Niazi, Alireza Afsharifar, Ali Moghadam, Somanath Kallolimath   +8 more
doaj   +1 more source

CD34+CD19-CD22+ B-cell progenitors might underlie phenotypic escape in patients treated with CD19-directed therapies [PDF]

, 2022
CD19-directed immunotherapies have revolutionized the treatment of advanced B-ALL. Despite initial impressive rates of complete remission (CR) many patients ultimately relapse.
Bataller, Alex, Barcena, Paloma, Elliott, Natalina, Trincado, Juan L., Trincado, Juan L, Gutierrez-Agüera, Francisco, Torrebadell, Montserrat, Rovira, Montse, Sole, F, Ribera, Josep María, Ribera, Jose-Maria, Elliot, Natalina, Urbano Ispizua, Álvaro, Roberts, Irene, Orfao, Alberto, Sole, Francesc, Zanetti, S. R, Barrena, Susana, Zanetti, Samanta Romina, Roy, Anindita, Rives, Susana, Menéndez Bujan, Pablo, Menéndez, Pablo, Urbano-Ispizua, Álvaro, Wang, Guanlin, O’Byrne, Sorcha, Mead, Adam J., Mallo, Mar, Mead, Adam J, Bueno, Clara, Juan, Manel, O'Byrne, Sorcha, Thongjuea, Supat, Ribera, Josep-Maria, Psaila, Bethan, Gonzalez, Maria, Trincado Alonso, Juan Luis, 1987-, Vega-García, Nerea, Sorigué, Marc, Torrebadell, Montse, Ortiz-Maldonado, Valentín, Delgado, Julio, Morgades, Mireia, Barrera, Susana, Rovira, Montserrat, Mallo, Maria del Mar, González-González, María   +46 more
core   +1 more source

Generation and characterization of CD19-iCre mice as a tool for efficient and specific conditional gene targeting in B cells

Scientific Reports, 2021
The Cre/loxP system is a powerful tool for generating conditional gene knockout (KO) mice and elucidate gene function in vivo. CD19-Cre and Mb1-iCre transgenic mice are commonly used for generating B cell-specific KO mice and investigate the development,
Tomoharu Yasuda, Yuichi Saito, Chisato Ono, Kazuhiko Kawata, Akemi Baba, Yoshihiro Baba   +5 more
doaj   +1 more source