Results 41 to 50 of about 177,018 (304)

Human IgA-Expressing Bone Marrow Plasma Cells Characteristically Upregulate Programmed Cell Death Protein-1 Upon B Cell Receptor Stimulation

Frontiers in Immunology, 2021
The functions of bone marrow plasma cells (BMPC) beyond antibody production are not fully elucidated and distinct subsets of BMPC suggest potential different functions.
Annika Wiedemann, Annika Wiedemann, Marie Lettau, Marie Lettau, Ina Wirries, Ina Wirries, Annemarie Jungmann, Abdulrahman Salhab, Gilles Gasparoni, Henrik E. Mei, Carsten Perka, Jörn Walter, Andreas Radbruch, Andreia C. Lino, Andreia C. Lino, Thomas Dörner, Thomas Dörner   +16 more
doaj   +1 more source

Preferential association of hepatitis C virus with CD19+ B cells is mediated by complement system [PDF]

, 2016
Extrahepatic disease manifestations are common in chronic hepatitis C virus (HCV) infection. The mechanism of HCV-related lymphoproliferative disorders is not fully understood.
Alter, Harvey J., Baré, Patricia, De Giorgi, Valeria, Grandinetti, Teresa, Matsuura, Kentaro, Salam, Kazi Abdus, Schechterly, Cathy, Wang, Richard   +7 more
core   +1 more source

Decreased B lymphocytes subpopulations are associated with higher atherosclerotic risk in elderly patients with moderate-to-severe chronic kidney diseases

BMC Nephrology, 2021
Aim Cardiovascular diseases (CVD) are the leading cause of death in patients with chronic kidney disease (CKD), and the risk of CVD increases with reductions in renal function.
Jieshan Lin, Bin Tang, Zhanwu Feng, Wenke Hao, Wenxue Hu   +4 more
doaj   +1 more source

Functional characterization of reappearing B cells after anti-CD20 treatment of CNS autoimmune disease. [PDF]

, 2018
The anti-CD20 antibody ocrelizumab, approved for treatment of multiple sclerosis, leads to rapid elimination of B cells from the blood. The extent of B cell depletion and kinetics of their recovery in different immune compartments is largely unknown ...
Bernard, Claude CA, Brück, Wolfgang, Feldmann, Linda, Häusler, Darius, Häusser-Kinzel, Silke, Lehmann-Horn, Klaus, Lepennetier, Gildas, Torke, Sebastian, Weber, Martin S, Zamvil, Scott S   +9 more
core   +1 more source

CD19 EKSİKLİĞİ TANISINDA RFLP YÖNTEMİNİN KULLANIMI

Genel Tıp Dergisi, 2021
B lenfosit yüzeyinde bulunan CD19 molekülü olgun B hücrelerinde CD21, CD81, CD225 ile birlikte CD19 kompleksini oluşturur ve antijen uyarısı ile birlikte B lenfosit aktivasyonunu düzenler. CD19 molekülünü kodlayan gende oluşacak mutasyonlar, CD19 protein
İsmail Reisli, Mehmet Karaselek, Hatice Efe, Hasan Kapaklı, Yahya Gül, Sevgi Keleş, Şükrü Güner, Ercan Kurar   +7 more
doaj   +1 more source

Mass spectrometry imaging identifies palmitoylcarnitine as an immunological mediator during Salmonella Typhimurium infection [PDF]

, 2017
Salmonella Typhimurium causes a self-limiting gastroenteritis that may lead to systemic disease. Bacteria invade the small intestine, crossing the intestinal epithelium from where they are transported to the mesenteric lymph nodes (MLNs) within migrating
A Perez-Lopez, A Srinivasan, AG Peniche, AL John St, AM Race, AS Attia, B Dugas, B Flatley, B García, BD Corbin, C Otsubo, C O’Mahony, CS Macedo de, E-H Hong, F Hacini-Rachinel, FM Goñi, G Robichaud, G Walzl, GM Fraser, IB Wenderska, J Bene, J Hess, JD Turner, JM Ertelt, JM Rutkowsky, K Schwamborn, KA Oswald-Richter, KHG Mills, KKW To, KL O’Hagan, KSH Beckham, M Barthel, M Gaya, MA Jepson, MC Mutomba, MI Hood, MP Fink, N Desbenoit, O Klein, P Mastroeni, PL Chen, R Daniels, R Rosales-Reyes, RJA Goodwin, S Gravius, S Létourneau, S Pie, S Voedisch, T Goto, T Liu, T Okada, TG Glaros, UT Nguyen, VD Peltekova, X Liu, Y Li, Y Souwer, YR Carrasco   +57 more
core   +1 more source

Blinatumomab Utilization in Pediatric B‐Cell Acute Lymphoblastic Leukemia: Experience From the Mountain West

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Blinatumomab is a bispecific T‐cell engager approved for the treatment of pediatric B‐cell acute lymphoblastic leukemia (B‐ALL). Outpatient home infusion reduces hospitalization burden and optimizes resource utilization, but is logistically challenging.
Angela Parra del Riego, Kellee Parker, William C. Thomsen, James B. Ford, Mallorie B. Heneghan, David Spencer Mangum, Jennifer L. McNeer, Luke D. Maese, Claire E. F. Miller, Richard Lemons, Taumoha Ghosh   +10 more
wiley   +1 more source

Blimp-1-dependent and -independent natural antibody production by B-1 and B-1-derived plasma cells. [PDF]

, 2017
Natural antibodies contribute to tissue homeostasis and protect against infections. They are secreted constitutively without external antigenic stimulation.
Baumgarth, Nicole, Lund, Frances E, Mousseau, Betty J, Savage, Hannah P, Sawhney, Sanjam S, Yenson, Vanessa M   +5 more
core   +1 more source

Emapalumab for Immune Effector Cell‐Associated Hemophagocytic Lymphohistiocytosis‐Like Syndrome Following CD19‐Directed CAR‐T in Two Patients With B‐ALL: Clinical and Biomarker Correlates

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Immune effector cell‐associated hemophagocytic lymphohistiocytosis‐like syndrome (IEC‐HS) is a life‐threatening hyperinflammatory toxicity distinct from cytokine release syndrome (CRS) and neurotoxicity following chimeric antigen receptor T‐cell (CAR‐T) therapy. In a single‐institution retrospective cohort of pediatric and young adult patients
Thomas J. Galletta, Jeremy D. Rubinstein, Christopher E. Dandoy, Ruby Khoury, Angela Faulhaber, Christine L. Phillips, Christa Krupski   +6 more
wiley   +1 more source

T cells expressing CD19-specific Engager Molecules for the Immunotherapy of CD19-positive Malignancies [PDF]

Scientific Reports, 2016
AbstractT cells expressing chimeric antigen receptors (CARs) or the infusion of bispecific T-cell engagers (BITEs) have shown antitumor activity in humans for CD19-positive malignancies. While BITEs redirect the large reservoir of resident T cells to tumors, CAR T cells rely on significant in vivo expansion to exert antitumor activity.
Mireya Paulina Velasquez, David Torres, Kota Iwahori, Sunitha Kakarla, Caroline Arber, Tania Rodriguez-Cruz, Arpad Szoor, Challice L. Bonifant, Claudia Gerken, Laurence J. N. Cooper, Xiao-Tong Song, Stephen Gottschalk   +11 more
openaire   +2 more sources