Results 31 to 40 of about 7,097 (193)

Perturbed CD8+ T cell TIGIT/CD226/PVR axis despite early initiation of antiretroviral treatment in HIV infected individuals. [PDF]

, 2017
HIV-specific CD8+ T cells demonstrate an exhausted phenotype associated with increased expression of inhibitory receptors, decreased functional capacity, and a skewed transcriptional profile, which are only partially restored by antiretroviral treatment (
Betts, Michael R, Buggert, Marcus, Deeks, Steven G, Frederiksen, Juliet, Hecht, Frederick M, Karlsson, Annika C, Ljunggren, Hans-Gustaf, Lund, Ole, Naji, Ali, Reyes-Terán, Gustavo, Scharf, Lydia, Sönnerborg, Anders, Tauriainen, Johanna   +12 more
core   +1 more source

Emerging patterns of genetic overlap across autoimmune disorders. [PDF]

, 2012
Most of the recently identified autoimmunity loci are shared among multiple autoimmune diseases. The pattern of genetic association with autoimmune phenotypes varies, suggesting that certain subgroups of autoimmune diseases are likely to share ...
Criswell, Lindsey A, Richard-Miceli, Corinne   +1 more
core   +1 more source

CD226 Attenuates Treg Proliferation via Akt and Erk Signaling in an EAE Model

Frontiers in Immunology, 2020
Cluster of differentiation 226 (CD226) molecules play a crucial role in the activation of effector CD4+ T cells during the immune response process, but a cell-intrinsic function of CD226 in CD4+ T subsets is not clear. In this study, we showed that Cd226−
Ning Wang, Ning Wang, Hongyu Yi, Liang Fang, Jingyi Jin, Qianli Ma, Yuting Shen, Juan Li, Shuang Liang, Jie Xiong, Zhuo Li, Hanyu Zeng, Fengliang Jiang, Boquan Jin, Lihua Chen   +14 more
doaj   +1 more source

Expression of CD226 is upregulated on Tr1 cells from neuromyelitis optica spectrum disorder patients

Brain and Behavior, 2022
Background Neuromyelitis optica spectrum disorder (NMOSD) is a central and acute demyelinating disease of the central nervous system with unusual clinical course.
Ping Chen, Mingmei Wu, Ning Wang, Feng Xia, Fang Du, Zhirong Liu, Jinchun Wang, Jingyi Jin, Boquan Jin, Gang Zhao, Lihua Chen, Jing Yi, Liang Fang   +12 more
doaj   +1 more source

Association of the AFF3 gene and IL2/IL21 gene region with juvenile idiopathic arthritis [PDF]

, 2010
Recent genetic studies have led to identification of numerous loci that are associated with susceptibility to autoimmune diseases. The strategy of using information from these studies has facilitated the identification of novel juvenile idiopathic ...
Barton, A., British Society of Paediatric and Adolescent Rheumatology (BSPAR) Study Group, Childhood Arthritis Prospective Study (CAPS), Eyre, S., Flynn, E., Gardner-Medwin, J. [CAPS and BSPAR study groups], Hinks, A., Ke, X., Martin, P., Packham, J., Thomson, W., UKRAG Consortium, Worthington, J.   +12 more
core   +1 more source

Immunosurveillance and therapy of multiple myeloma are CD226 dependent [PDF]

Journal of Clinical Investigation, 2015
Multiple myeloma (MM) is an age-dependent hematological malignancy. Evaluation of immune interactions that drive MM relies on in vitro experiments that do not reflect the complex cellular stroma involved in MM pathogenesis. Here we used Vk*MYC transgenic mice, which spontaneously develop MM, and demonstrated that the immune system plays a critical role
Camille, Guillerey, Lucas, Ferrari de Andrade, Slavica, Vuckovic, Kim, Miles, Shin Foong, Ngiow, Michelle C R, Yong, Michele W L, Teng, Marco, Colonna, David S, Ritchie, Marta, Chesi, Martha, Chesi, P Leif, Bergsagel, Geoffrey R, Hill, Mark J, Smyth, Ludovic, Martinet   +14 more
openaire   +4 more sources

Modeling the Cumulative Genetic Risk for Multiple Sclerosis from Genome-Wide Association Data [PDF]

, 2011
Background: Multiple sclerosis (MS) is the most common cause of chronic neurologic disability beginning in early to middle adult life. Results from recent genome-wide association studies (GWAS) have substantially lengthened the list of disease loci and ...
Bahlo, M, Baranzini, SE, Booth, DR, Broadley, SA, Brown, MA, Butzkueven, H, Carroll, W, Chibnik, LB, Danoy, P, de Bakker, PIW, De Jager, PL, Foote, SJ, Greer, J, Griffiths, LR, Hafler, DA, Hauser, SL, Kappos, L, Kermode, A, Kilpatrick, TJ, Lechner-Scott, J, Matthews, PM, Moscato, P, Oksenberg, JR, Pappas, D, Pelletier, D, Perreau, VM, Polman, CH, Rubio, JP, Scott, RJ, Slee, M, Stankovich, J, Stewart, GJ, Taylor, BV, Wang, JH, Wiley, J   +34 more
core   +12 more sources

The TIGIT/CD226 Axis Regulates Human T Cell Function [PDF]

The Journal of Immunology, 2012
Abstract T cell Ig and ITIM domain (TIGIT) is a newly identified receptor expressed on T cells that binds to CD155 on the dendritic cell surface, driving them to a more tolerogenic phenotype. Given that TIGIT contains an ITIM motif in its intracellular domain and considering the potential importance of the TIGIT/CD226 pathway in human ...
Ester, Lozano, Margarita, Dominguez-Villar, Vijay, Kuchroo, David A, Hafler   +3 more
openaire   +2 more sources

DNAM-1 and the TIGIT/PVRIG/TACTILE Axis: Novel Immune Checkpoints for Natural Killer Cell-Based Cancer Immunotherapy [PDF]

, 2019
Natural killer (NK) cells are lymphocytes of the innate immune response characterized by their role in the destruction of tumor cells. Activation of NK cells depend on a fine balance between activating and inhibitory signals mediated by different ...
Alonso, Corona, Arcos, María José, Bañas, Helena, Bergua, Juan M., Casas-Avilés, Ignacio, Durán, Esther, Hassouneh, Fakhri, López-Sejas, Nelson, Pera Rojas, Alejandra, Solana, Rafael, Sánchez-Correa, Beatriz, Tarazona, Raquel, Valhondo, Isabel   +12 more
core   +1 more source

Novel associations for hypothyroidism include known autoimmune risk loci [PDF]

, 2011
Hypothyroidism is the most common thyroid disorder, affecting about 5% of the general population. Here we present the first large genome-wide association study of hypothyroidism, in 2,564 cases and 24,448 controls from the customer base of 23andMe, Inc.,
A Alcina, A Bender, A Petrone, A Teumer, A Zhernakova, AA Zeitlin, Amr H. Sawalha, Amy K. Kiefer, C Cotsapas, C Newton-Cheh, CB Do, Chuong B. Do, D Falush, D Smyth, David A. Hinds, F Menconi, G Lettre, H Donner, H Fraser, H Hakonarson, H Ikegami, I Landa, J Gudmundsson, J Lowe, JA Todd, JC Barrett, JC Denny, JE Wigginton, JH Cho, Joanna L. Mountain, Joyce Y. Tung, K Fujikawa, L Arnaud-Lopez, L Criswell, M Castanet, M Hayashi, M Sirota, M Velaga, MJ Coenen, MJ Simmonds, N Eriksson, N Movilla, N Tandon, Nicholas Eriksson, P Burton, P Chen, P Gourh, P Gregersen, P Newby, RC Betz, RJ Pruim, SM Park, TJ Giordano, Uta Francke, V Panicker, X Chu, Y Tomer, YH Lee   +57 more
core   +16 more sources