Results 41 to 50 of about 7,097 (193)
OncoImmunology, 2021 NK and CD8+ T cells are the main cytolytic effectors involved in innate and adaptive tumor immune surveillance, respectively. Although their educational pathways differ, similarities in their development and function suggest that CD8+ T lymphocytes could
Lourdes Gimeno +13 more
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OncoImmunology, 2017 CD226 is an activating receptor expressed on natural killer (NK) cells, CD8+ T cells, and other immune cells. Upon binding to its ligands expressed on target cells, CD226 activates intracellular signaling that triggers cytokine production and ...
Ji Sung Kim +9 more
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Mediators of Inflammation, 2022 Allergic rhinitis (AR) is an immunoglobulin E-mediated type 2 inflammation of the nasal mucosa that is mainly driven by type 2 helper T cells (Th2) and type 2 innate lymphoid cells (ILC2s).
Yang Xie +9 more
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Haematologica, 2023 T-cell immunoreceptor with Ig and ITIM domains (TIGIT) is an inhibitory checkpoint receptor that negatively regulates Tcell responses. CD226 competes with TIGIT for binding to the CD155 ligand, delivering a positive signal to the T cell. Here we studied
Francesca Arruga +15 more
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CD226 Gly307Ser association with multiple autoimmune diseases: A meta-analysis [PDF]
Human Immunology, 2013 Recently, there has been increasing evidence shown that a non-synonymous exchange (Gly307Ser/rs763361) of the CD226 gene on chromosome 18q22 is linked to several autoimmune diseases (ADs) including type 1 diabetes (T1D), celiac disease (CED), rheumatoid arthritis (RA), multiple sclerosis (MS), Grave's disease, Wegener's granulomatosis (WG), psoriasis ...
Zhi-Xin, Qiu +4 more
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Tumor rejection by the poliovirus receptor family ligands of the DNAM-1(CD226) receptor [PDF]
, 2006 The poliovirus receptor CD155 and its family member CD112 (nectin-2) are the ligands for the activating cell-surface receptor DNAM-1 on CD8(+) T cells and natural killer (NK) cells. Here, we demonstrate that, whereas the RMA tumor grew in syngeneic mice,
Honda Shin-ichiro +12 more
core +1 more source
Inhibition of bromodomain and extra-terminal (BET) proteins increases NKG2D ligand MICA expression and sensitivity to NK cell-mediated cytotoxicity in multiple myeloma cells. role of cMYC-IRF4-miR-125b interplay [PDF]
, 2016 Background: Anticancer immune responses may contribute to the control of tumors after conventional chemotherapy and different observations have indicated that chemotherapeutic agents can induce immune responses resulting in cancer cell death and immune ...
Abruzzese, MARIA PIA +13 more
core +15 more sources
Identification of CD226 ligand on colo205 cell surface
World Journal of Gastroenterology, 2002 To confirm the existence of CD226 ligand and its distribution, which is a novel molecule cloned in 1996.The mRNA was extracted from TPA activated Jurkat cells and used as a template for reverse-transcription. After PCR amplification, the fragment including CD226 extracellular region and the splice donor sequence "ACTTACCTGT" was obtained and cloned ...
Kai, Sun +6 more
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Expression of CD226 in preeclamptic placentas and its role in trophoblast function [PDF]
Yixue xinzhi zazhiObjective To analyze the expression characteristics of CD226 in placental tissues from preeclampsia (PE) patients and its biological function in trophoblast cells.Methods CD226 mRNA transcript levels and protein expression in placental tissues from the ...
YU Yang +6 more
doaj +1 more source
Identification and characterization of murine DNAM-1 (CD226) and its poliovirus receptor family ligands [PDF]
, 2005 journal ...
Hara Ayumi +5 more
core +1 more source